Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Hepatitis D006505 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Schindler CW et al. Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. 2016 Psychopharmacology (Berl.) pmid:26803499
Panlilio LV et al. Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. 2016 Psychopharmacology (Berl.) pmid:26558620
Williams CM and Kirkham TC Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. 1999 Psychopharmacology (Berl.) pmid:10353436
Fernandez-Espejo E and Galan-Rodriguez B Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor. 2004 Psychopharmacology (Berl.) pmid:15088080
Vlachou S et al. Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. 2006 Psychopharmacology (Berl.) pmid:16953388
Mallet PE and Beninger RJ The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. 1998 Psychopharmacology (Berl.) pmid:9862397
Cassano T et al. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. 2011 Psychopharmacology (Berl.) pmid:21042794
Morera-Herreras T et al. Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats. 2011 Psychopharmacology (Berl.) pmid:20959968
Costa B et al. Precipitated and spontaneous withdrawal in rats tolerant to anandamide. 2000 Psychopharmacology (Berl.) pmid:10805606
Haller J et al. The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. 2013 Psychopharmacology (Berl.) pmid:23743650
Resstel LB et al. Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. 2008 Psychopharmacology (Berl.) pmid:18446325
Cippitelli A et al. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. 2008 Psychopharmacology (Berl.) pmid:18446329
McMahon LR Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. 2009 Psychopharmacology (Berl.) pmid:18592221
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345
Mangieri RA et al. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. 2009 Psychopharmacology (Berl.) pmid:19343330
Schacht JP et al. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. 2009 Psychopharmacology (Berl.) pmid:19002671
Dudášová A et al. The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig. 2013 Pulm Pharmacol Ther pmid:23428645
Qi M et al. A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. 2015 Rapid Commun. Mass Spectrom. pmid:26411510
Shaladi AM et al. [Cannabinoids in the control of pain]. 2008 Recenti Prog Med pmid:19388223
Luce V et al. The inhibitory effect of anandamide on oxytocin and vasopressin secretion from neurohypophysis is mediated by nitric oxide. 2014 Regul. Pept. pmid:24342802
Nakata M and Yada T Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. 2008 Regul. Pept. pmid:17884194
Scotchie JG et al. Endocannabinoid regulation in human endometrium across the menstrual cycle. 2015 Reprod Sci pmid:24819878
Fonseca BM et al. Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. 2009 Reprod. Biol. Endocrinol. pmid:19860893
Taylor AH et al. Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. 2011 Reprod. Biol. Endocrinol. pmid:22126420
Vercelli CA et al. Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus. 2009 Reprod. Biomed. Online pmid:19490788
Ribeiro ML et al. 17beta-oestradiol and progesterone regulate anandamide synthesis in the rat uterus. 2009 Reprod. Biomed. Online pmid:19192341
Bariani MV et al. Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. 2015 Reproduction pmid:26347521
Gervasi MG et al. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. 2009 Reproduction pmid:19042982
Talevi R et al. Is there a role for endocannabinoids in sperm-oviduct interaction? 2010 Reproduction pmid:20511399
Almada M et al. The endocannabinoid anandamide impairs in vitro decidualization of human cells. 2016 Reproduction pmid:27568210
Langstein J et al. cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. 1996 Jul-Aug Res. Immunol. pmid:8903105
Kopczyńska B and Szereda-Przestaszewska M Supranodose vagotomy eliminates anandamide-evoked cardiorespiratory depression in anaesthetized rats. 2006 Respir Physiol Neurobiol pmid:16144778
Brăiloiu C et al. [Endothelium-derived hyperpolarizing factor]. 1998 Jul-Dec Rev Med Chir Soc Med Nat Iasi pmid:10756843
Rodríguez de Fonseca F [The endocannabinoid system and food intake control]. 2004 Apr-Jun Rev Med Univ Navarra pmid:15382609
Hauer D et al. Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. 2012 Rev Neurosci pmid:23006898
Di Marzo V Endocannabinoids: synthesis and degradation. 2008 Rev. Physiol. Biochem. Pharmacol. pmid:18481028
Leweke FM et al. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. 2007 Schizophr. Res. pmid:17566707
Song Y et al. Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor. 2015 Sci Rep pmid:26541090
Krishnan G and Chatterjee N Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. 2015 Sci Rep pmid:25943894
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Derkinderen P et al. Regulation of a neuronal form of focal adhesion kinase by anandamide. 1996 Science pmid:8781236
Karsak M et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. 2007 Science pmid:17556587
Barinaga M Pot, heroin unlock new areas for neuroscience. 1992 Science pmid:1335165
Devane WA et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. 1992 Science pmid:1470919
Marx J Drug development. Drugs inspired by a drug. 2006 Science pmid:16424309
Oliver D et al. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. 2004 Science pmid:15031437
Mechoulam R and Lichtman AH Neuroscience. Stout guards of the central nervous system. 2003 Science pmid:14526067
Marsicano G et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. 2003 Science pmid:14526074
Van Sickle MD et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. 2005 Science pmid:16224028
Beltramo M et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. 1997 Science pmid:9262477
Ueda N and Tsuboi K [Enzymes involved in the biosynthesis and degradation of anandamide]. 2005 Seikagaku pmid:16440755
Ueda N [Anandamide: an endogenous cannabinoid receptor agonist]. 1995 Seikagaku pmid:7594870
Yan MS et al. [Cannabinoids, cannabinoid receptor and immune response]. 2000 Sheng Li Ke Xue Jin Zhan pmid:12545719
Zhang J et al. Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. 2013 Sheng Li Xue Bao pmid:23598867
Villanueva A et al. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. 2009 Shock pmid:19295473
Motobe T et al. Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. 2004 Shock pmid:14676677
Murillo-Rodriguez E et al. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. 2003 Sleep pmid:14746372
Huitron-Resendiz S et al. Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. 2004 Sleep pmid:15453543
Malvindi MA et al. Rod-shaped nanocrystals elicit neuronal activity in vivo. 2008 Small pmid:18844306
Bari M et al. Characterization of the endocannabinoid system in mouse embryonic stem cells. 2011 Stem Cells Dev. pmid:20446814
Plant LD et al. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. 2002 Stroke pmid:12215606
Mishima K et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. 2005 Stroke pmid:15845890
Schäbitz WR et al. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. 2002 Stroke pmid:12154273
Oz M et al. Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. 2002 Synapse pmid:12325042
Morera-Herreras T et al. Regulation of subthalamic neuron activity by endocannabinoids. 2010 Synapse pmid:20336631
Ishiguro H et al. Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. 2011 Synapse pmid:20506567
Lee TT et al. Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. 2013 Synapse pmid:22987804
Hohmann AG and Herkenham M Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study. 2000 Synapse pmid:10842353
Ueda N and Yamamoto S [Anandamide: a marijuana-like compound produced in animal tissues]. 1995 Tanpakushitsu Kakusan Koso pmid:8532892
Kase Y et al. Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. 2008 Ther Apher Dial pmid:18937720
Krumbholz A et al. Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. 2013 Ther Drug Monit pmid:23942543
Maccarrone M The blissful state of endothelium. 2003 Thromb. Haemost. pmid:12719771
Yamaji K et al. Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. 2003 Thromb. Haemost. pmid:12719786
Maccarrone M et al. Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. 2006 Thromb. Haemost. pmid:16543970
Harada N et al. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. 2006 Thromb. Haemost. pmid:16732381
Okamoto H et al. Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. 2000 Thromb. Res. pmid:10942792
Descalzi F et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. 2013 Tissue Eng Part A pmid:23578218
Matsuda K et al. The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. 2005 Tohoku J. Exp. Med. pmid:16141678
Kaplan BL et al. Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. 2005 Toxicol. Appl. Pharmacol. pmid:15893538
Kondakala S et al. Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. 2017 Toxicol. Appl. Pharmacol. pmid:29097212
Quistad GB et al. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. 2001 Toxicol. Appl. Pharmacol. pmid:11350214
Vilela LR et al. Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. 2015 Toxicol. Appl. Pharmacol. pmid:25933444
Kodani SD et al. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. 2016 Toxicol. Lett. pmid:27659731
Carr RL et al. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. 2011 Toxicol. Sci. pmid:21507991
Carr RL et al. Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. 2013 Toxicol. Sci. pmid:23761300
Hsu SS et al. Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. 2007 Toxicology pmid:17222495
Bluett RJ et al. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. 2014 Transl Psychiatry pmid:25004388
Leweke FM et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. 2012 Transl Psychiatry pmid:22832859
Maccarrone M et al. Intracellular trafficking of anandamide: new concepts for signaling. 2010 Trends Biochem. Sci. pmid:20570522
Alhouayek M and Muccioli GG The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. 2012 Trends Mol Med pmid:22917662
Gaetani S et al. Anandamide hydrolysis: a new target for anti-anxiety drugs? 2003 Trends Mol Med pmid:14604824
Maccarrone M Inhibition of anandamide hydrolysis: cells also know how to do it. 2004 Trends Mol Med pmid:14720580
Mechoulam R et al. Cannabinoids and brain injury: therapeutic implications. 2002 Trends Mol Med pmid:11815270
Szallasi A and Di Marzo V New perspectives on enigmatic vanilloid receptors. 2000 Trends Neurosci. pmid:11006466
Devane WA New dawn of cannabinoid pharmacology. 1994 Trends Pharmacol. Sci. pmid:8165721
Zygmunt PM et al. Anandamide - the other side of the coin. 2000 Trends Pharmacol. Sci. pmid:10664604
Di Marzo V and Maccarrone M FAAH and anandamide: is 2-AG really the odd one out? 2008 Trends Pharmacol. Sci. pmid:18394720
Smart D and Jerman JC Anandamide: an endogenous activator of the vanilloid receptor. 2000 Trends Pharmacol. Sci. pmid:10740287
Fowler CJ Has FLAT fallen flat? 2014 Trends Pharmacol. Sci. pmid:24398120
Di Marzo V et al. Anandamide: some like it hot. 2001 Trends Pharmacol. Sci. pmid:11431028