Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Seagard JL et al. Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14615281
Ortega-Gutiérrez S et al. Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. 2004 Biochemistry pmid:15209515
D'Amico M et al. Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus. 2004 Neurochem. Res. pmid:15260134
Boldrup L et al. A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. 2004 J. Biochem. Biophys. Methods pmid:15262451
Lichtman AH et al. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. 2004 J. Pharmacol. Exp. Ther. pmid:15229230
Dennedy MC et al. Cannabinoids and the human uterus during pregnancy. 2004 Am. J. Obstet. Gynecol. pmid:14749627
Moezi L et al. Potentiation of anandamide effects in mesenteric beds isolated from bile duct-ligated rats: role of nitric oxide. 2004 Eur. J. Pharmacol. pmid:14751408
Piomelli D THC: moderation during implantation. 2004 Nat. Med. pmid:14702623
Arizzi MN et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. 2004 Life Sci. pmid:14672756
Battista N et al. Endocannabinoids and their involvement in the neurovascular system. 2004 Curr Neurovasc Res pmid:16185189
Joseph J et al. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. 2004 Cancer Immunol. Immunother. pmid:15034673
Ligresti A et al. Further evidence for the existence of a specific process for the membrane transport of anandamide. 2004 Biochem. J. pmid:14969584
Guo J and Ikeda SR Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. 2004 Mol. Pharmacol. pmid:14978245
Basta PV et al. Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide. 2004 J. Immunol. Methods pmid:14980433
Fernández-Solari J et al. Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14981261
Rodríguez de Fonseca F [The endocannabinoid system and food intake control]. 2004 Apr-Jun Rev Med Univ Navarra pmid:15382609
Mechoulam R The promise of advances in the field of endocannabinoids. 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159675
Fride E The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159678
Russo EB Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? 2004 Feb-Apr Neuro Endocrinol. Lett. pmid:15159679
Lam PM et al. Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. 2005 Br J Anaesth pmid:15722382
Oddi S et al. Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes. 2005 Cell. Mol. Life Sci. pmid:15723173
Rodella LF et al. AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation. 2005 Eur. J. Pharmacol. pmid:15680264
Oz M et al. Additive effects of endogenous cannabinoid anandamide and ethanol on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. 2005 J. Pharmacol. Exp. Ther. pmid:15687372
Mbvundula EC et al. Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. 2005 Biochem. Pharmacol. pmid:15670582
Ashton CH et al. Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. 2005 J. Psychopharmacol. (Oxford) pmid:15888515
Guo Y et al. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. 2005 J. Biol. Chem. pmid:15890658
Fowler CJ and Tiger G Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. 2005 Biochem. Pharmacol. pmid:15794945
Lambert DM and Fowler CJ The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. 2005 J. Med. Chem. pmid:16078824
Hayase T et al. Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands. 2005 Behav Pharmacol pmid:16148444
Myrdal SE and Steyger PS TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. 2005 Hear. Res. pmid:15925202
Pisani A et al. High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients. 2005 Ann. Neurol. pmid:15852389
Venderova K et al. Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus. 2005 Exp. Neurol. pmid:15899265
Monteleone P et al. Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. 2005 Neuropsychopharmacology pmid:15841111
Price TJ et al. A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons. 2005 Neuropharmacology pmid:15992578
Taddei S Evolving the concept of regulation of vascular tone in humans. 2005 Br. J. Pharmacol. pmid:15997231
Appendino G et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. 2005 J. Pharmacol. Exp. Ther. pmid:15356216
Hohmann AG et al. An endocannabinoid mechanism for stress-induced analgesia. 2005 Nature pmid:15973410
O'Sullivan SE et al. Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. 2005 Eur. J. Pharmacol. pmid:15659311
Glaser ST et al. Anandamide transport: a critical review. 2005 Life Sci. pmid:15979096
Ambrosi S et al. On the importance of anandamide structural features for its interactions with DPPC bilayers: effects on PLA2 activity. 2005 J. Lipid Res. pmid:15961786
Tian X et al. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. 2005 J. Biol. Chem. pmid:15964843
Ueda N et al. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines. 2005 Life Sci. pmid:15949819
Gamber KM et al. Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. 2005 Neuropharmacology pmid:15949823
Karava V et al. Anandamide metabolism by Tetrahymena pyriformis in vitro. Characterization and identification of a 66 kDa fatty acid amidohydrolase. 2005 Biochimie pmid:15951097
Kwolek G et al. [Influence of anandamide, the endogenous agonist of cannabinoid receptors on the circulatory system]. 2005 Postepy Hig Med Dosw (Online) pmid:15928605
Bojesen IN and Hansen HS Membrane transport of anandamide through resealed human red blood cell membranes. 2005 J. Lipid Res. pmid:15930521
Fowler CJ et al. The endocannabinoid signaling system: pharmacological and therapeutic aspects. 2005 Pharmacol. Biochem. Behav. pmid:15935456
De Petrocellis L and Di Marzo V Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. 2005 Life Sci. pmid:15936040
Balas L et al. Synthesis of a photoactivatable probe of the anandamide re-uptake. 2005 Nat. Prod. Res. pmid:15938150
Bouaboula M et al. Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. 2005 Eur. J. Pharmacol. pmid:15987634
Fezza F et al. Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity. 2005 Anal. Biochem. pmid:15766717
Ueda N and Tsuboi K [Enzymes involved in the biosynthesis and degradation of anandamide]. 2005 Seikagaku pmid:16440755
De Bank PA et al. A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. 2005 Biochem. Pharmacol. pmid:15794939
Elphick MR and Egertová M The phylogenetic distribution and evolutionary origins of endocannabinoid signalling. 2005 Handb Exp Pharmacol pmid:16596778
Wiley JL et al. Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice. 2005 Eur. J. Pharmacol. pmid:15740725
Tóth A et al. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. 2005 Life Sci. pmid:15820503
Pacher P et al. Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15821037
O'Sullivan SE et al. The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. 2005 Br. J. Pharmacol. pmid:15821751
Chen J et al. Finding of endocannabinoids in human eye tissues: implications for glaucoma. 2005 Biochem. Biophys. Res. Commun. pmid:15823551
Chen JZ et al. Preferred conformations of endogenous cannabinoid ligand anandamide. 2005 Life Sci. pmid:15826873
Zhang N et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15764707
Kvasnicka T [Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. 2005 Cas. Lek. Cesk. pmid:15807291
Minowa S et al. Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. 2005 Brain Res. pmid:15781048
Sandberg A and Fowler CJ Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin. 2005 Chem. Phys. Lipids pmid:15784231
Chen P et al. Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. 2005 Microvasc. Res. pmid:15797258
Thomas A et al. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. 2005 Br. J. Pharmacol. pmid:16205722
Li C et al. High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor. 2005 J. Med. Chem. pmid:16190768
Valenti M et al. The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake. 2005 J. Neurochem. pmid:16135090
Matsuda K et al. The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. 2005 Tohoku J. Exp. Med. pmid:16141678
Rossato M et al. Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. 2005 J. Clin. Endocrinol. Metab. pmid:15562018
Suplita RL et al. Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. 2005 Neuropharmacology pmid:16129456
Osei-Hyiaman D et al. Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. 2005 Neuroendocrinology pmid:16131814
Mechoulam R and Deutsch DG Toward an anandamide transporter. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16314567
Ligresti A et al. Endocannabinoid metabolic pathways and enzymes. 2005 Curr Drug Targets CNS Neurol Disord pmid:16375679
Flygare J et al. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. 2005 FEBS Lett. pmid:16337199
Voets T et al. Sensing with TRP channels. 2005 Nat. Chem. Biol. pmid:16408004
Siegmund SV and Brenner DA Molecular pathogenesis of alcohol-induced hepatic fibrosis. 2005 Alcohol. Clin. Exp. Res. pmid:16344593
Gobbi G et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16352709
Sarnataro D et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. 2005 FEBS Lett. pmid:16263116
Van Sickle MD et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. 2005 Science pmid:16224028
Jiang W et al. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. 2005 J. Clin. Invest. pmid:16224541
Di S et al. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. 2005 J. Physiol. (Lond.) pmid:16239276
Kim HI et al. Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. 2005 Brain Res. pmid:16256960
Kadoi Y et al. Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. 2005 Crit. Care Med. pmid:16276190
Brizzi A et al. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. 2005 J. Med. Chem. pmid:16279794
Singh Tahim A et al. Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. 2005 Neuroscience pmid:16198486
Cabranes A et al. Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. 2005 Neurobiol. Dis. pmid:16242629
Yamaguchi Y et al. [Surgical stress]. 2005 Nihon Geka Gakkai Zasshi pmid:16045189
Wagner JA et al. Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. 2005 J. Cardiovasc. Pharmacol. pmid:16116341
McPartland JM et al. Cannabimimetic effects of osteopathic manipulative treatment. 2005 J Am Osteopath Assoc pmid:16118355
Schuel H and Burkman LJ A tale of two cells: endocannabinoid-signaling regulates functions of neurons and sperm. 2005 Biol. Reprod. pmid:16120829
Besana A et al. Lipids and two-pore domain K+ channels in excitable cells. 2005 Prostaglandins Other Lipid Mediat. pmid:16099395
van der Stelt M and Di Marzo V Anandamide as an intracellular messenger regulating ion channel activity. 2005 Prostaglandins Other Lipid Mediat. pmid:16099396
Patsos HA et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. 2005 Gut pmid:16099783
Yoshihara S et al. Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways. 2005 Int. Arch. Allergy Immunol. pmid:16103691
van der Stelt M et al. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. 2005 EMBO J. pmid:16107881
Lynch DL and Reggio PH Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics. 2005 J. Med. Chem. pmid:16033262
Wahn H et al. The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:16055511
Bari M et al. Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. 2005 J. Biol. Chem. pmid:15657045
Kim SR et al. Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. 2005 J. Neurosci. pmid:15659603