Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Sordelli MS et al. The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. 2011 PLoS ONE pmid:21559512
Liao YS et al. [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts]. 2011 Zhonghua Zhong Liu Za Zhi pmid:21575494
McHugh D et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. 2012 Br. J. Pharmacol. pmid:21595653
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Khanna IK and Alexander CW Fatty acid amide hydrolase inhibitors--progress and potential. 2011 CNS Neurol Disord Drug Targets pmid:21631410
Hofmann ME et al. Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. 2011 J. Physiol. (Lond.) pmid:21646412
Whyte LS et al. Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. 2012 Br. J. Pharmacol. pmid:21649637
Pamplona FA and Takahashi RN Psychopharmacology of the endocannabinoids: far beyond anandamide. 2012 J. Psychopharmacol. (Oxford) pmid:21652605
Romani R et al. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? 2011 Biochimie pmid:21664223
Warzecha Z et al. Role of sensory nerves in gastroprotective effect of anandamide in rats. 2011 J. Physiol. Pharmacol. pmid:21673369
Martín-Couce L et al. Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. 2011 J. Med. Chem. pmid:21675776
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Zoerner AA et al. Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma. 2011 Clin. Pharmacol. Ther. pmid:21716266
Brailoiu GC et al. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. 2011 J. Biol. Chem. pmid:21719698
Catanzaro G et al. Effect of capacitation on the endocannabinoid system of mouse sperm. 2011 Mol. Cell. Endocrinol. pmid:21723369
Zoerner AA et al. Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21752730
Kopczyńska B et al. Anandamide enhances expression of heat shock proteins Hsp70 and Hsp25 in rat lungs. 2011 Eur. J. Pharmacol. pmid:21756900
Hayase T Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. 2011 BMC Pharmacol. pmid:21767384
Goonawardena AV et al. Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. 2011 Oct-Nov Neuropharmacology pmid:21767554
Theile JW and Cummins TR Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. 2011 Mol. Pharmacol. pmid:21788423
Lin QS et al. Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. 2011 Brain Res. Bull. pmid:21801815
Tsuboi K et al. Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. 2011 Biochim. Biophys. Acta pmid:21801852
Chianese R et al. Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. 2011 Gen. Comp. Endocrinol. pmid:21802420
Yoshino H et al. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. 2011 J. Physiol. (Lond.) pmid:21807615
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Palermo G et al. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. 2011 J. Med. Chem. pmid:21830831
Gatta-Cherifi B et al. Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. 2012 Int J Obes (Lond) pmid:21844878
Altinsoy A et al. A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. 2011 J Ocul Pharmacol Ther pmid:21848425
Mestre L et al. Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. 2011 J Neuroinflammation pmid:21851608
Clugston RD et al. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. 2011 J. Lipid Res. pmid:21856784
Dollery C Investigative clinical pharmacology. 2011 Clin. Pharmacol. Ther. pmid:21862965
Weller K et al. TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release. 2011 Neuropeptides pmid:21868092
Ndong C et al. Cloning and pharmacological characterization of the dog cannabinoid CBâ‚‚receptor. 2011 Eur. J. Pharmacol. pmid:21871882
Romero TR et al. The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs. 2011 Nitric Oxide pmid:21875681
Feledziak M et al. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. 2011 J. Med. Chem. pmid:21899370
Roy A et al. Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat. 2012 J. Appl. Physiol. pmid:21903882
Butler RK et al. Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. 2012 J. Psychopharmacol. (Oxford) pmid:21926424
Dean C Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. 2011 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:21940402
Thomas KC et al. Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. 2012 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21949157
Alenmyr L et al. TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. 2011 Clin Physiol Funct Imaging pmid:21981454
Izumi Y and Zorumski CF NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. 2012 Neuropsychopharmacology pmid:21993209
Frazier CJ Key questions of endocannabinoid signalling in the CNS: which, where and when? 2011 J. Physiol. (Lond.) pmid:22001725
Haas MJ et al. Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. 2012 Obesity (Silver Spring) pmid:22016100
Malinowska B et al. Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? 2012 Br. J. Pharmacol. pmid:22022923
Ito T et al. Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells. 2011 Kurume Med J pmid:22027193
Heyman E et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. 2012 Psychoneuroendocrinology pmid:22029953
Brizzi A et al. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. 2011 J. Med. Chem. pmid:22044209
Hamtiaux L et al. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. 2011 PLoS ONE pmid:22046372
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Fu J et al. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. 2012 Nat. Neurosci. pmid:22101642
Feuerecker M et al. Effects of exercise stress on the endocannabinoid system in humans under field conditions. 2012 Eur. J. Appl. Physiol. pmid:22101870
Taylor AH et al. Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. 2011 Reprod. Biol. Endocrinol. pmid:22126420
Reyes-Cabello C et al. Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration. 2012 Pharmacol. Biochem. Behav. pmid:22133635
Cippitelli A et al. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. 2011 PLoS ONE pmid:22140525
Wheal AJ et al. Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries. 2012 Eur. J. Pharmacol. pmid:22154756
Li Q et al. Effects of anandamide on potassium channels in rat ventricular myocytes: a suppression of I(to) and augmentation of K(ATP) channels. 2012 Am. J. Physiol., Cell Physiol. pmid:22173869
Wu X et al. Alteration of endocannabinoid system in human gliomas. 2012 J. Neurochem. pmid:22176552
Starowicz K et al. Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. 2012 Neuropharmacology pmid:22178705
Jang Y et al. Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. 2012 J. Biol. Chem. pmid:22187434
Marsicano G and Chaouloff F Moving bliss: a new anandamide transporter. 2012 Nat. Neurosci. pmid:22193249
Battista N et al. Abnormal anandamide metabolism in celiac disease. 2012 J. Nutr. Biochem. pmid:22209002
Schulte K et al. Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. 2012 Naunyn Schmiedebergs Arch. Pharmacol. pmid:22215206
Fowler CJ et al. Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide. 2013 J Enzyme Inhib Med Chem pmid:22225576
Harvey BS et al. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. 2012 Neurotoxicology pmid:22233683
Jarzimski C et al. Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol? 2012 Br J Clin Pharmacol pmid:22242687
Umathe SN et al. Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. 2012 Neuropharmacology pmid:22248639
Feuerecker M et al. Effect of an acute consumption of a moderate amount of ethanol on plasma endocannabinoid levels in humans. 2012 May-Jun Alcohol Alcohol. pmid:22278319
Czikora Á et al. Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation. 2012 Life Sci. pmid:22285599
Alger BE Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. 2012 J. Physiol. (Lond.) pmid:22289914
Sun Y et al. Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes. 2012 J. Pharmacol. Sci. pmid:22293299
Fowler CJ Anandamide uptake explained? 2012 Trends Pharmacol. Sci. pmid:22297258
Izzo AA et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. 2012 Br. J. Pharmacol. pmid:22300105
Battista N et al. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. 2012 Mol. Cell. Endocrinol. pmid:22305972
Liu J et al. Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. 2012 Gastroenterology pmid:22307032
Psychoyos D et al. Cannabinoid receptor 1 signaling in embryo neurodevelopment. 2012 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:22311661
Rajesh M et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. 2012 Diabetes pmid:22315315
Shi RZ et al. Decreased anandamide transporter activity and calcitonin gene-related peptide production in spontaneously hypertensive rats: role of angiotensin II. 2012 Eur. J. Pharmacol. pmid:22318155
McLaughlin RJ et al. Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. 2012 Eur Neuropsychopharmacol pmid:22325231
Newberry EP et al. Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. 2012 J. Lipid Res. pmid:22327204
Zhang X et al. Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. 2012 Mol. Pharmacol. pmid:22328719
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. 2012 Obesity (Silver Spring) pmid:22334255
Osycka-Salut C et al. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. 2012 PLoS ONE pmid:22363468
Gatta L et al. Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. 2012 PLoS ONE pmid:22363560
Manna SS and Umathe SN Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. 2012 Epilepsy Res. pmid:22386872
Fogaça MV et al. Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. 2012 Braz. J. Med. Biol. Res. pmid:22392189
Lisboa SF and Guimarães FS Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. 2012 Neuropharmacology pmid:22394688
Romano MR and Lograno MD Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery. 2012 Eur. J. Pharmacol. pmid:22429572
Pucci M et al. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. 2012 J. Biol. Chem. pmid:22431736
Dubreucq S et al. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. 2012 Neuropsychopharmacology pmid:22434220
Monteleone P et al. Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. 2012 J. Clin. Endocrinol. Metab. pmid:22442280
Andrianova EL et al. In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. 2011 Bull. Exp. Biol. Med. pmid:22442796
Kenessey I et al. Revisiting CB1 receptor as drug target in human melanoma. 2012 Pathol. Oncol. Res. pmid:22447182
Petrovszki Z et al. The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. 2012 Anesth. Analg. pmid:22451592
Sharir H et al. The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. 2012 J Neuroimmune Pharmacol pmid:22454039
Simpson CD et al. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. 2012 Apoptosis pmid:22488300
Xiong W et al. A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. 2012 J. Neurosci. pmid:22496565
Tamaki C et al. Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilatation in the rat mesenteric vascular bed. 2012 J. Pharmacol. Sci. pmid:22510966
Czifra G et al. Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. 2012 J. Invest. Dermatol. pmid:22513781
Miller LL et al. Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. 2012 J. Pharmacol. Exp. Ther. pmid:22514333
Caprioli A et al. The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. 2012 J. Pharmacol. Exp. Ther. pmid:22514334