Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Zenor BN et al. Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. 1999 Life Sci. pmid:10416818
Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. 1999 J. Biol. Chem. pmid:9915812
Beltramo M and Piomelli D Anandamide transport inhibition by the vanilloid agonist olvanil. 1999 Eur. J. Pharmacol. pmid:9920187
Chaytor AT et al. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. 1999 J. Physiol. (Lond.) pmid:10523421
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Mombouli JV et al. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. 1999 Br. J. Pharmacol. pmid:10323591
Watanabe K et al. Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride. 1999 Biol. Pharm. Bull. pmid:10328555
Mechoulam R and Ben-Shabat S From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis. 1999 Nat Prod Rep pmid:10331283
Burstein SH The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential. 1999 Pharmacol. Ther. pmid:10341359
Di Marzo V et al. Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments. 1999 Lipids pmid:10419192
Hansen HS et al. Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity. 1999 Lipids pmid:10419193
Kiss Z Anandamide stimulates phospholipase D activity in PC12 cells but not in NIH 3T3 fibroblasts. 1999 FEBS Lett. pmid:10214947
Maccarrone M et al. Anandamide activates human platelets through a pathway independent of the arachidonate cascade. 1999 FEBS Lett. pmid:10214961
Yang HY et al. GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat. 1999 J. Neurochem. pmid:10217273
Raffa RB et al. Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice. 1999 Neurosci. Lett. pmid:10218903
De Petrocellis L et al. Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response. 1999 Neuroscience pmid:10392859
Williams CM and Kirkham TC Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. 1999 Psychopharmacology (Berl.) pmid:10353436
Fimiani C et al. Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: coupling to nitric oxide release. 1999 Cell. Signal. pmid:10353693
Ng EW et al. Unique analogues of anandamide: arachidonyl ethers and carbamates and norarachidonyl carbamates and ureas. 1999 J. Med. Chem. pmid:10354405
Ameri A et al. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. 1999 Br. J. Pharmacol. pmid:10372827
Self DW Anandamide: a candidate neurotransmitter heads for the big leagues. 1999 Nat. Neurosci. pmid:10204533
Giuffrida A et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. 1999 Nat. Neurosci. pmid:10204543
Paria BC et al. Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period. 1999 Biol. Reprod. pmid:10208977
Járai Z et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570211
Sagan S et al. Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes. 1999 Eur. J. Neurosci. pmid:10051770
Kobayashi H et al. Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. 1999 J Toxicol Sci pmid:10073332
Bisogno T et al. Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function. 1999 Biochem. Biophys. Res. Commun. pmid:10079192
Fleming I et al. Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists. 1999 Br. J. Pharmacol. pmid:10193775
Hohmann AG et al. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord. 1999 Brain Res. pmid:10082879
Wang J et al. Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development. 1999 Biol. Reprod. pmid:10084956
Ishioka N and Bukoski RD A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation. 1999 J. Pharmacol. Exp. Ther. pmid:10087011
Wiley JL Cannabis: discrimination of "internal bliss"? 1999 Pharmacol. Biochem. Behav. pmid:10515300
Walker JM et al. Pain modulation by release of the endogenous cannabinoid anandamide. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518599
Katayama K et al. Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme. 1999 Biochim. Biophys. Acta pmid:10521704
Molderings GJ et al. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship. 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10494885
Leweke FM et al. Elevated endogenous cannabinoids in schizophrenia. 1999 Neuroreport pmid:10501554
Akinshola BE et al. Anandamide inhibition of recombinant AMPA receptor subunits in Xenopus oocytes is increased by forskolin and 8-bromo-cyclic AMP. 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10543424
Di Marzo V et al. Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids. 1999 Curr. Med. Chem. pmid:10469888
McAllister SD et al. Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system. 1999 J. Pharmacol. Exp. Ther. pmid:10525080
Yousif MH and Oriowo MA Inhibitory effects of cannabinoid receptor ligands on electrically-evoked responses in rat isolated tracheal ring segments. 1999 Pharmacol. Res. pmid:10527656
Zygmunt PM et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. 1999 Nature pmid:10440374
Martin BR et al. Discovery and characterization of endogenous cannabinoids. 1999 Life Sci. pmid:10462059
Khanolkar AD and Makriyannis A Structure-activity relationships of anandamide, an endogenous cannabinoid ligand. 1999 Life Sci. pmid:10462061
Howlett AC et al. Signal transduction of eicosanoid CB1 receptor ligands. 1999 Life Sci. pmid:10462062
Di Marzo V Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators. 1999 Life Sci. pmid:10462065
Ueda N et al. An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. 1999 FEBS Lett. pmid:10431820
Fowler CJ et al. Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen. 1999 Arch. Biochem. Biophys. pmid:9989926
Basavarajappa BS and Hungund BL Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells. 1999 J. Neurochem. pmid:9930723
Wagner JA et al. Mesenteric vasodilation mediated by endothelial anandamide receptors. 1999 Hypertension pmid:9931142
Goparaju SK et al. Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. 1999 Biochem. Pharmacol. pmid:9933030
Lu R et al. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. 1999 Am. J. Physiol. pmid:9950961
Gifford AN et al. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). 1999 Eur. J. Pharmacol. pmid:10556675
Melck D et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. 1999 FEBS Lett. pmid:10606728
González S et al. Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. 1999 Life Sci. pmid:10447218
Gebremedhin D et al. Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. 1999 Am. J. Physiol. pmid:10362691
Melck D et al. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. 1999 Biochem. Biophys. Res. Commun. pmid:10448105
Lang W et al. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. 1999 J. Med. Chem. pmid:10072686
Bisogno T et al. Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. 1999 Arch. Biochem. Biophys. pmid:10577359
Childers SR and Breivogel CS Cannabis and endogenous cannabinoid systems. 1998 Jun-Jul Drug Alcohol Depend pmid:9716939
Brăiloiu C et al. [Endothelium-derived hyperpolarizing factor]. 1998 Jul-Dec Rev Med Chir Soc Med Nat Iasi pmid:10756843
Bisogno T et al. Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation. 1998 Eur. J. Biochem. pmid:9688276
Levin M and Mercola M Gap junctions are involved in the early generation of left-right asymmetry. 1998 Dev. Biol. pmid:9806775
Aceto MD et al. Anandamide, an endogenous cannabinoid, has a very low physical dependence potential. 1998 J. Pharmacol. Exp. Ther. pmid:9808686
Murillo-Rodríguez E et al. Anandamide modulates sleep and memory in rats. 1998 Brain Res. pmid:9813364
Jaggar SI et al. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. 1998 Neurosci. Lett. pmid:9774165
Fulton D and Quilley J Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat. 1998 J. Pharmacol. Exp. Ther. pmid:9732371
Welch SP et al. Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A. 1998 J. Pharmacol. Exp. Ther. pmid:9732392
Fields HL and Meng ID Watching the pot boil. 1998 Nat. Med. pmid:9734389
Pate DW et al. Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. 1998 Life Sci. pmid:9851310
Molina-Holgado F et al. The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. 1998 FEBS Lett. pmid:9738948
Stefano GB et al. Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications. 1998 Int. J. Cardiol. pmid:9687087
Stefano GB Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release. 1998 J. Neuroimmunol. pmid:9610675
Smith FL et al. Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats. 1998 Pharmacol. Biochem. Behav. pmid:9610941
Gurwitz D and Kloog Y Do endogenous cannabinoids contribute to HIV-mediated immune failure? 1998 Mol Med Today pmid:9612798
Prevot V et al. Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation. 1998 Brain Res. pmid:9593913
Di Marzo V 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. 1998 Biochim. Biophys. Acta pmid:9630590
Stefano GB et al. Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues. 1998 Brain Res. pmid:9630717
Schmid PC et al. Alternative pathways of anandamide biosynthesis in rat testes. 1998 Chem. Phys. Lipids pmid:9631536
Varga K et al. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. 1998 FASEB J. pmid:9707176
Mallet PE and Beninger RJ Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance. 1998 Life Sci. pmid:9651110
De Petrocellis L et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9653194
Berdyshev E et al. Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. 1998 Life Sci. pmid:9718090
Jaggar SI et al. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. 1998 Pain pmid:9696473
Bisogno T et al. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. 1998 Biochem. Biophys. Res. Commun. pmid:9703957
Mallet PE and Beninger RJ The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. 1998 Psychopharmacology (Berl.) pmid:9862397
Stahl SM Getting stoned without inhaling: anandamide is the brain's natural marijuana. 1998 J Clin Psychiatry pmid:9862600
Derocq JM et al. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. 1998 FEBS Lett. pmid:9563506
Chakrabarti A et al. Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. 1998 Brain Res. Bull. pmid:9434204
Wiley JL et al. Evaluation of cannabimimetic effects of structural analogs of anandamide in rats. 1998 Eur. J. Pharmacol. pmid:9760024
Lichtman AH et al. Effects of SR 141716A after acute or chronic cannabinoid administration in dogs. 1998 Eur. J. Pharmacol. pmid:9797029
Di Marzo V et al. Interactions between synthetic vanilloids and the endogenous cannabinoid system. 1998 FEBS Lett. pmid:9801167
Stein EA et al. Selective effects of the endogenous cannabinoid arachidonylethanolamide (anandamide) on regional cerebral blood flow in the rat. 1998 Neuropsychopharmacology pmid:9803424
Randall MD and Kendall DA Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery. 1998 Eur. J. Pharmacol. pmid:9617751
Edgemond WS et al. Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. 1998 Mol. Pharmacol. pmid:9658204
Tong W et al. Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis. 1998 J. Med. Chem. pmid:9784095
Richardson JD et al. Antihyperalgesic effects of spinal cannabinoids. 1998 Eur. J. Pharmacol. pmid:9600630
Hampson AJ et al. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. 1998 J. Neurochem. pmid:9453561
Kimura T et al. Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor. 1998 Biol. Pharm. Bull. pmid:9556149
Pratt PF et al. N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. 1998 Am. J. Physiol. pmid:9458889
Qureshi J et al. Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol. 1998 Mol. Cell. Biochem. pmid:9562238