Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Gubellini P et al. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. 2002 J. Neurosci. pmid:12177188
Andersson DA et al. Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists. 2002 Mol. Pharmacol. pmid:12181448
Goutopoulos A and Makriyannis A From cannabis to cannabinergics: new therapeutic opportunities. 2002 Pharmacol. Ther. pmid:12182958
Hansen HS et al. Putative neuroprotective actions of N-acyl-ethanolamines. 2002 Pharmacol. Ther. pmid:12182959
Randall MD et al. Cardiovascular effects of cannabinoids. 2002 Pharmacol. Ther. pmid:12182966
Kagaya M et al. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. 2002 Br. J. Pharmacol. pmid:12183329
Someya A et al. Arachidonic acid release and prostaglandin F(2alpha) formation induced by anandamide and capsaicin in PC12 cells. 2002 Eur. J. Pharmacol. pmid:12206851
Plant LD et al. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. 2002 Stroke pmid:12215606
Burstein SH et al. Regulation of anandamide tissue levels by N-arachidonylglycine. 2002 Biochem. Pharmacol. pmid:12234618
Anikwue R et al. Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration. 2002 J. Pharmacol. Exp. Ther. pmid:12235269
Rueda D et al. The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. 2002 J. Biol. Chem. pmid:12237305
Schuel H et al. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. 2002 Mol. Reprod. Dev. pmid:12237954
Kozak KR et al. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. 2002 J. Biol. Chem. pmid:12244105
Oz M et al. Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. 2002 Synapse pmid:12325042
Ralevic V et al. Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function. 2002 Life Sci. pmid:12354577
Laine K et al. Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12356827
Wallace MJ et al. Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. 2002 Eur. J. Pharmacol. pmid:12359270
Roberts LA et al. Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. 2002 Br. J. Pharmacol. pmid:12359623
Barthó L et al. Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle. 2002 Naunyn Schmiedebergs Arch. Pharmacol. pmid:12382081
Milton NG Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. 2002 Neurosci. Lett. pmid:12384227
González S et al. Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine. 2002 Brain Res. pmid:12393235
Maccarrone M et al. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. 2002 Blood pmid:12393387
Mascolo N et al. The endocannabinoid system and the molecular basis of paralytic ileus in mice. 2002 FASEB J. pmid:12397089
Del Arco I et al. Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404. 2002 Eur. J. Pharmacol. pmid:12409011
Jia Y et al. Anandamide induces cough in conscious guinea-pigs through VR1 receptors. 2002 Br. J. Pharmacol. pmid:12411414
Geraghty DP and Mazzone SB Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide. 2002 Br. J. Pharmacol. pmid:12411424
Gómez R et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. 2002 J. Neurosci. pmid:12417686
Krylatov AV et al. Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism. 2002 Bull. Exp. Biol. Med. pmid:12428277
van der Stelt M et al. Acute neuronal injury, excitotoxicity, and the endocannabinoid system. 2002 Oct-Dec Mol. Neurobiol. pmid:12428763
Szoke E et al. Neonatal anandamide treatment results in prolonged mitochondrial damage in the vanilloid receptor type 1-immunoreactive B-type neurons of the rat trigeminal ganglion. 2002 Neuroscience pmid:12435419
Higgs S et al. Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. 2003 Psychopharmacology (Berl.) pmid:12447606
Jerman JC et al. Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. 2002 Br J Anaesth pmid:12453933
Schmid PC et al. Anandamide and other N-acylethanolamines in human tumors. 2002 Lipids pmid:12458627
Kathuria S et al. Modulation of anxiety through blockade of anandamide hydrolysis. 2003 Nat. Med. pmid:12461523
Maccarrone M et al. Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. 2003 Endocrinology pmid:12488326
Orliac ML et al. Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. 2003 J. Pharmacol. Exp. Ther. pmid:12490589
Schelegle ES Functional morphology and physiology of slowly adapting pulmonary stretch receptors. 2003 Anat Rec A Discov Mol Cell Evol Biol pmid:12494485
Lee LY et al. Functional morphology and physiological properties of bronchopulmonary C-fiber afferents. 2003 Anat Rec A Discov Mol Cell Evol Biol pmid:12494486
Liu YC and Wu SN Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. 2003 Eur. J. Pharmacol. pmid:12498905
Németh J et al. Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. 2003 Neurosci. Lett. pmid:12499047
Palmer SL et al. Cannabinergic ligands. 2002 Chem. Phys. Lipids pmid:12505686
Razdan RK and Mahadevan A Recent advances in the synthesis of endocannabinoid related ligands. 2002 Chem. Phys. Lipids pmid:12505687
Kunos G et al. The quest for a vascular endothelial cannabinoid receptor. 2002 Chem. Phys. Lipids pmid:12505689
Wiley JL and Martin BR Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. 2002 Chem. Phys. Lipids pmid:12505690
Schmid HH et al. Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges. 2002 Chem. Phys. Lipids pmid:12505695
Cravatt BF and Lichtman AH The enzymatic inactivation of the fatty acid amide class of signaling lipids. 2002 Chem. Phys. Lipids pmid:12505696
Paria BC et al. Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation. 2002 Chem. Phys. Lipids pmid:12505701
Facchinetti F et al. Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide. 2003 Glia pmid:12509806
Sancho R et al. Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. 2003 Mol. Pharmacol. pmid:12527815
McVey DC et al. Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). 2003 J. Pharmacol. Exp. Ther. pmid:12538826
Yan MS et al. [Cannabinoids, cannabinoid receptor and immune response]. 2000 Sheng Li Ke Xue Jin Zhan pmid:12545719
Ahluwalia J et al. Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. 2003 J. Neurochem. pmid:12558978
Pearlman RJ et al. Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. 2003 J. Neurochem. pmid:12558979
Jennings EA et al. The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. 2003 J. Physiol. (Lond.) pmid:12562891
Lo YK et al. Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells. 2003 Biochem. Pharmacol. pmid:12566085
Chu CJ et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. 2003 J. Biol. Chem. pmid:12569099
Scorticati C et al. The effect of anandamide on prolactin secretion is modulated by estrogen. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12578974
Randall MD A new endothelial target for cannabinoids. 2003 Mol. Pharmacol. pmid:12606752
Wisnoskey BJ et al. Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry. 2003 Biochem. J. pmid:12608892
Vandevoorde S et al. N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity. 2003 Bioorg. Med. Chem. pmid:12614867
Lau AH and Chow SS Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells. 2003 Eur. J. Pharmacol. pmid:12620517
Li J et al. Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. 2003 Hypertension pmid:12623992
Perrier JF et al. 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. 2003 J. Physiol. (Lond.) pmid:12626670
Campanucci VA et al. A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. 2003 J. Physiol. (Lond.) pmid:12640017
Sarker KP et al. ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. 2003 J. Neurochem. pmid:12641726
Holt S and Fowler CJ Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. 2003 Naunyn Schmiedebergs Arch. Pharmacol. pmid:12644895
Glaser ST et al. Evidence against the presence of an anandamide transporter. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12655057
Derkinderen P et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. 2003 J. Neurosci. pmid:12657697
Melck D et al. Cannabimimetic eicosanoids in cancer and inflammation: an update. 2002 Adv. Exp. Med. Biol. pmid:12664614
Vandevoorde S et al. Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide. 2003 J. Med. Chem. pmid:12672243
López-Rodríguez ML et al. Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. 2003 J. Med. Chem. pmid:12672252
Costanzi M et al. Anandamide and memory in CD1 mice: effects of immobilization stress and of prior experience. 2003 Neurobiol Learn Mem pmid:12676519
Basavarajappa BS et al. Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. 2003 Eur. J. Pharmacol. pmid:12679143
Jonsson KO et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. 2003 Arch. Toxicol. pmid:12698235
Maccarrone M et al. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. 2003 J. Neurochem. pmid:12716433
Marinelli S et al. Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. 2003 J. Neurosci. pmid:12716921
Maccarrone M The blissful state of endothelium. 2003 Thromb. Haemost. pmid:12719771
Yamaji K et al. Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. 2003 Thromb. Haemost. pmid:12719786
Juntunen J et al. Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. 2003 Eur J Pharm Sci pmid:12729860
Ortar G et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. 2003 Biochem. Pharmacol. pmid:12732359
Clement AB et al. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. 2003 J. Neurosci. pmid:12736361
Hermann H et al. Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. 2003 Cell. Mol. Life Sci. pmid:12737320
Mimeault M et al. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. 2003 Prostate pmid:12746841
López-Rodríguez ML et al. Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. 2003 Eur J Med Chem pmid:12750028
Fowler CJ et al. Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. 2003 J Enzyme Inhib Med Chem pmid:12751821
Tóth A et al. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. 2003 Life Sci. pmid:12759142
Ahern GP Activation of TRPV1 by the satiety factor oleoylethanolamide. 2003 J. Biol. Chem. pmid:12761211
Veldhuis WB et al. Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. 2003 J. Neurosci. pmid:12764100
Oz M et al. The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. 2003 J. Pharmacol. Exp. Ther. pmid:12766252
Tarzia G et al. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. 2003 J. Med. Chem. pmid:12773040
Vásquez C et al. Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. 2003 Can. J. Physiol. Pharmacol. pmid:12774849
El Fangour S et al. Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. 2003 Bioorg. Med. Chem. Lett. pmid:12781177
Maccarrone M et al. Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. 2003 J. Biol. Chem. pmid:12799380
Han J et al. Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. 2003 J. Physiol. (Lond.) pmid:12807991
Patel S et al. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. 2003 J. Pharmacol. Exp. Ther. pmid:12808005
Shiraishi T et al. The presence of ceramidase activity in liver nuclear membrane. 2003 Biol. Pharm. Bull. pmid:12808285
Klegeris A et al. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. 2003 Br. J. Pharmacol. pmid:12813001
Wilson SJ et al. A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase. 2003 Anal. Biochem. pmid:12814631
Maccarrone M et al. The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. 2003 J. Biol. Chem. pmid:12815050
Ahluwalia J et al. Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. 2003 Eur. J. Neurosci. pmid:12823468