Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Paria BC et al. Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period. 1999 Biol. Reprod. pmid:10208977
Wang J et al. Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development. 1999 Biol. Reprod. pmid:10084956
Cobellis G et al. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. 2006 Biol. Reprod. pmid:16611862
Yang ZM et al. Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development. 1996 Biol. Reprod. pmid:8879486
Sun X et al. Genetic loss of Faah compromises male fertility in mice. 2009 Biol. Reprod. pmid:18987328
Paria BC et al. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. 1998 Biol. Reprod. pmid:9623610
Schuel H and Burkman LJ A tale of two cells: endocannabinoid-signaling regulates functions of neurons and sperm. 2005 Biol. Reprod. pmid:16120829
Wang X et al. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. 2016 Biomed Res Int pmid:26904688
Spaziano G et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. 2015 Biomed Res Int pmid:25866824
Malek N et al. Alterations in the anandamide metabolism in the development of neuropathic pain. 2014 Biomed Res Int pmid:25276812
Koga D et al. High-performance liquid chromatography and fluorometric detection of arachidonylethanolamide (anandamide) and its analogues, derivatized with 4-(N-chloroformylmethyl-N-methyl)amino-7-N,N-dimethylaminosulp honyl-2,1 ,3- benzoxadiazole (DBD-COCl). 1995 Jan-Feb Biomed. Chromatogr. pmid:7734936
Schmidt A et al. Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. 2006 Biomed. Chromatogr. pmid:16189813
Arai Y et al. Sensitive determination of anandamide in rat brain utilizing a coupled-column HPLC with fluorimetric detection. 2000 Biomed. Chromatogr. pmid:10694706
Brizzi A et al. Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17561406
Duarte CD et al. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. 2007 Bioorg. Med. Chem. pmid:17275312
Di Marzo V et al. The anandamide membrane transporter. Structure-activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region. 2004 Bioorg. Med. Chem. pmid:15351399
Vandevoorde S et al. N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity. 2003 Bioorg. Med. Chem. pmid:12614867
Osman NA et al. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands. 2010 Bioorg. Med. Chem. pmid:21074998
Bourne C et al. Novel, potent THC/anandamide (hybrid) analogs. 2007 Bioorg. Med. Chem. pmid:17827022
Parkkari T et al. Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide. 2006 Bioorg. Med. Chem. pmid:16644227
Kono M et al. Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. 2014 Bioorg. Med. Chem. pmid:24440478
Ferreri C et al. Synthesis of all-trans anandamide: a substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation. 2008 Bioorg. Med. Chem. pmid:18782671
Wyffels L et al. Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. 2009 Bioorg. Med. Chem. pmid:19054678
Boger DL et al. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. 2001 Bioorg. Med. Chem. Lett. pmid:11412972
Sit SY et al. Novel inhibitors of fatty acid amide hydrolase. 2007 Bioorg. Med. Chem. Lett. pmid:17459705
El Fangour S et al. Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. 2003 Bioorg. Med. Chem. Lett. pmid:12781177
Parkkari T et al. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives. 2004 Bioorg. Med. Chem. Lett. pmid:15149681
Segall Y et al. Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. 2003 Bioorg. Med. Chem. Lett. pmid:12951114
Ortar G et al. New tetrazole-based selective anandamide uptake inhibitors. 2008 Bioorg. Med. Chem. Lett. pmid:18424134
Balas L et al. Synthesis of a potential photoactivatable anandamide analog. 2006 Bioorg. Med. Chem. Lett. pmid:16682198
Yao F et al. Development of novel tail-modified anandamide analogs. 2008 Bioorg. Med. Chem. Lett. pmid:18723350
Urbani P et al. New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. 2006 Bioorg. Med. Chem. Lett. pmid:16213718
Aneetha H et al. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. 2009 Bioorg. Med. Chem. Lett. pmid:19013794
Morefield SI et al. Drug evaluations using neuronal networks cultured on microelectrode arrays. 2000 Biosens Bioelectron pmid:11219752
Psychoyos D et al. Cannabinoid receptor 1 signaling in embryo neurodevelopment. 2012 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:22311661
Nallendran V et al. The plasma levels of the endocannabinoid, anandamide, increase with the induction of labour. 2010 BJOG pmid:20406230
Ghasemi M et al. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. 2007 BJU Int. pmid:17850365
Maccarrone M et al. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. 2002 Blood pmid:12393387
Valk P et al. Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. 1997 Blood pmid:9269762
Bradshaw HB et al. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. 2009 BMC Biochem. pmid:19460156
Neelamegan D et al. Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum. 2012 BMC Microbiol. pmid:22730904
Hayase T Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. 2011 BMC Pharmacol. pmid:21767384
Kumar S Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates. 2015 BMC Res Notes pmid:25595103
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Gesell FK et al. Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. 2013 BMC Vet. Res. pmid:24370333
Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. 2009 Bone pmid:19059369
Lam PM et al. Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. 2005 Br J Anaesth pmid:15722382
Davies JW et al. Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population. 2010 Br J Anaesth pmid:20354008
Jerman JC et al. Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. 2002 Br J Anaesth pmid:12453933