(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

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Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alopecia Areata D000506 6 associated lipids
Alzheimer Disease D000544 76 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Body Weight D001835 333 associated lipids
Brain Diseases D001927 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Pimm MV et al. Suppression of an ascitic rat hepatoma with cord factor and Nocardia cell wall skeleton in squalene emulsions. 1980 Eur J Cancer pmid:7227439
Sirtori CR et al. Reduced triglyceridemia and increased high density lipoprotein cholesterol levels after treatment with acipimox, a new inhibitor of lipolysis. 1981 Feb-Mar Atherosclerosis pmid:7225165
Brassell SC et al. Specific acyclic isoprenoids as biological markers of methanogenic bacteria in marine sediments. 1981 Nature pmid:7219553
Lindholm JS and Downing DT Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. 1980 Lipids pmid:7219074
Yarkoni E et al. Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate. 1981 Infect. Immun. pmid:7216489
Trocha PJ and Sprinson DB Location and regulation of early enzymes of sterol biosynthesis in yeast. 1976 Arch. Biochem. Biophys. pmid:7207
Miettinen TA Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. 1982 J. Lipid Res. pmid:7200504
Albers-Jackson B et al. Incorporation of 14C acetate into the sterols of rabbit lens in organ culture. 1982-1983 Curr. Eye Res. pmid:7184713
Bird S and Gower DB Axillary 5 alpha-androst-16-en-3-one, cholesterol and squalene in men; preliminary evidence for 5 alpha-androst-16-en-3-one being a product of bacterial action. 1982 J. Steroid Biochem. pmid:7176644
PokrovskiÄ­ AA et al. [Method of isolating, identifying and quantitatively determining alkanes, cycloalkanes, monocyclic arenes and squalene in animal organs and tissues]. 1978 Sep-Oct Vopr Pitan pmid:716335
Bell FP and Hubert EV Stimulation of hepatic squalene and triglyceride synthesis by dimethylsulfoxide, in vitro. 1982 Lipids pmid:7162368
Morin RJ and Srikantaiah MV Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds. 1982 Pharmacol Res Commun pmid:7156175
Olugbade TA et al. Chemical constituents of Cnestis ferruginea DC. I. Petroleum ether fraction. 1982 J Ethnopharmacol pmid:7154704
Maugh TH Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. 1982 Science pmid:7146911
Morozova RP et al. [Separation of lipid extract from animal blood and tissues and isolation of squalene and sterols from it]. 1982 Jul-Aug Ukr. Biokhim. Zh. pmid:7135500
Emmons GT et al. Effects of 20,25-diazacholesterol on cholesterol synthesis in cultured chick muscle cells: a radiogas chromatographic and mass spectrometric study of the post-squalene sector. 1982 Biomed. Mass Spectrom. pmid:7126761
Tilvis RS and Miettinen TA Fate of intravenously administered squalene in the rat. 1982 Biochim. Biophys. Acta pmid:7126611
Dillard CJ et al. Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. 1982 Res. Commun. Chem. Pathol. Pharmacol. pmid:7122999
Saudek CD et al. Plasma squalene: lipoprotein distribution and kinetic analysis. 1978 J. Lipid Res. pmid:712242
Morin RJ et al. Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities. 1982 Lipids pmid:7121212
Tilvis R et al. Metabolism of squalene in human fat cells. Demonstration of a two-pool system. 1982 J. Biol. Chem. pmid:7107606
Tiffany JM Individual variations in human meibomian lipid composition. 1978 Exp. Eye Res. pmid:710541
Torinuki W et al. Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. 1982 Tohoku J. Exp. Med. pmid:7101278
Richter E and Schäfer SG The effect of squalane on the absorption of dietary cholesterol by the rat. 1982 Res Exp Med (Berl) pmid:7100640
Richter E and Schäfer SG Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice. 1982 J Environ Sci Health B pmid:7096897
Messeri G et al. Amniotic fluid squalene and gestational age. 1982 Clin. Chem. pmid:7094305
Richter E et al. Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. 1982 Chem. Biol. Interact. pmid:7083398
Tilvis RS et al. Lipid composition of bile and gallbladder mucosa in patients with acalculous cholesterolosis. 1982 Gastroenterology pmid:7060883
Pratt HP Preimplantation mouse embryos synthesize membrane sterols. 1982 Dev. Biol. pmid:7054002
Bach D and Miller IR Glyceryl monooleate black lipid membranes obtained from squalene solutions. 1980 Biophys. J. pmid:7053057
Takatsuji H et al. Formation of dehydrosqualene catalyzed by squalene synthetase in Saccharomyces cerevisiae. 1982 J. Biochem. pmid:7042703
Masuda A et al. Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis. 1982 J. Antibiot. pmid:7042672
Schroepfer GJ Sterol biosynthesis. 1981 Annu. Rev. Biochem. pmid:7023367
Yarkoni E and Rapp HJ Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs. 1980 Infect. Immun. pmid:6995325
White SH Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene. 1978 Biophys. J. pmid:698340
Torinuki W et al. [Emission spectral analysis of ultraweak chemiluminescence from linolenic acid and squalene peroxides (author's transl)]. 1982 Nihon Hifuka Gakkai Zasshi pmid:6978954
Yoshino K and Matsuo I [Squalene peroxide formation by UVA irradiation with or without 8-MOP (author's transl)]. 1981 Nihon Hifuka Gakkai Zasshi pmid:6971356
Jenkins DT et al. Amniotic fluid squalene: a useful test in prolonged pregnancy. 1982 Aust N Z J Obstet Gynaecol pmid:6959611
Moroyama T [Sterol metabolism of cultured skin tissue of chick embryo and the effect of anticholesterolemic drugs and chemical carcinogens on it (author's transl)]. 1981 Hiroshima Daigaku Shigaku Zasshi pmid:6953141
Tornabene TG et al. Phytanyl-glycerol ethers and squalenes in the archaebacterium Methanobacterium thermoautotrophicum. 1978 J. Mol. Evol. pmid:691077
Tornabene TG Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. 1978 J. Mol. Evol. pmid:691076
Lapointe JY and Laprade R Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. 1982 Biophys. J. pmid:6896832
Tilvis R and Miettinen TA Squalene, methyl sterol, and cholesterol levels in human organs. Postmortem analysis of their distributions. 1980 Arch. Pathol. Lab. Med. pmid:6892520
Kudchodkar BJ et al. Mechanisms of hypolipidemic action of nicotinic acid. 1978 Clin. Pharmacol. Ther. pmid:688728
Palamarchuk VI et al. [Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia]. 1983 May-Jun Vopr. Med. Khim. pmid:6880121
Hérodin F and Dormont D [Comparative kinetics of spleen cell-mediated antibody-dependent cytotoxic activity in mice treated with BCG or Mycobacterium smegmatis]. 1983 Mar-Apr Ann. Immunol. (Paris) pmid:6870194
Ohkuma T et al. Intensification of host's immunity by squalene in sarcoma 180 bearing ICR mice. 1983 J. Pharmacobio-dyn. pmid:6864440
Tanio Y et al. Regression of line-10 hepatocarcinoma with synthetic quinonyl muramyl dipeptide in strain-2 guinea pigs. 1983 Gan pmid:6862142
Tilvis RS and Miettinen TA Absorption and metabolic fate of dietary 3H-squalene in the rat. 1983 Lipids pmid:6855483
Fuks-Holmberg D and Bloch K Intermembrane transfer of squalene promoted by supernatant protein factor. 1983 J. Lipid Res. pmid:6854149
Crilly JF and Earnshaw JC Photon correlation spectroscopy of bilayer lipid membranes. 1983 Biophys. J. pmid:6838962
Tilvis RS and Miettinen TA Dietary squalene increases tissue sterols and fecal bile acids in the rat. 1983 Lipids pmid:6835033
Pasechnik VI [Cooperative analysis of measurements of capacity and optical parameters of bilayer lipid membranes]. 1983 Jan-Feb Biofizika pmid:6830905
Schroepfer GJ Sterol biosynthesis. 1982 Annu. Rev. Biochem. pmid:6810750
Kling D and Gamble W Cholesterol biosynthesis in polychlorinated biphenyl-treated rats. 1982 Environ. Res. pmid:6802634
Yamanishi Y et al. Serum squalene levels in hepatobiliary diseases. 1978 Clin. Chim. Acta pmid:679482
Rohmer M et al. Non-specific lanosterol and hopanoid biosynthesis be a cell-free system from the bacterium Methylococcus capsulatus. 1980 Eur. J. Biochem. pmid:6780348
Bouvier P et al. Non-specific biosynthesis of gammacerane derivatives by a cell-free system from the protozoon Tetrahymena pyriformis. Conformations of squalene, (3S)-squalene epoxide and (3R)-squalene epoxide during the cyclization. 1980 Eur. J. Biochem. pmid:6780347
Miettinen TA Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. 1980 Eur. J. Clin. Invest. pmid:6768564
Hata S et al. Effect of detergents on sterol synthesis in a cell-free system of yeast. 1982 J. Lipid Res. pmid:6752317
Buttke TM and Pyle AL Effects of unsaturated fatty acid deprivation on neutral lipid synthesis in Saccharomyces cerevisiae. 1982 J. Bacteriol. pmid:6752117
Salvioli G et al. Relationships between squalene and cholesterol in bile: effect of ursodeoxycholic acid administration in patients with radiolucent gallstones. 1984 Metab. Clin. Exp. pmid:6738365
Uotani J [The changes of sterol in lenses]. 1984 Nippon Ganka Gakkai Zasshi pmid:6711397
Wysocki SJ et al. Simultaneous assessment of fetal lung maturity and sebaceous gland function by gas chromatography. 1984 Clin. Chim. Acta pmid:6705230
Gavey KL and Scallen TJ Studies on the conversion of enzymatically generated, microsome-bound squalene to sterol. 1978 J. Biol. Chem. pmid:670211
Amdur BH et al. Presence of squalene in gram-positive bacteria. 1978 J. Bacteriol. pmid:670148
Yachnin S and Mannickarottu V Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. 1984 Blood pmid:6696995
Dykes PJ et al. Analysis of the non-ionic detergent-soluble lipids of human stratum corneum. 1984 Br. J. Dermatol. pmid:6696844
Zaaijer D and van der Horst CJ Cyclic changes in hormones, carbohydrates and indole metabolism in cervical mucus of normal, fertilizing cows and the relationship with non-fertility. 1983 Cytobios pmid:6684538
Aguilera JA et al. Incorporation of mevalonate into squalene, lanosterol and cholesterol by different neonatal chick tissues. 1983 Int. J. Biochem. pmid:6653866
Rahier A et al. Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. 1983 Biochem. Soc. Trans. pmid:6642064
Bell FP and Hubert EV Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. 1983 Lipids pmid:6633175
Strandberg TE Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo. 1983 Lipids pmid:6621260
Kajiyama G et al. Serum squalene in patients with gallstones. 1983 Hiroshima J. Med. Sci. pmid:6618897
Linares A et al. Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. 1984 Rev. Esp. Fisiol. pmid:6531508
Peyronel D et al. Fatty acid and squalene compositions of Mediterranean Centrophorus SPP egg and liver oils in relation to age. 1984 Lipids pmid:6503627
Schroeder F et al. Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. 1984 Biochem. Biophys. Res. Commun. pmid:6497882
Ohsawa K et al. The possible role of squalene and its peroxide of the sebum in the occurrence of sunburn and protection from the damage caused by U.V. irradiation. 1984 J Toxicol Sci pmid:6481825
Chin J and Bloch K Role of supernatant protein factor and anionic phospholipid in squalene uptake and conversion by microsomes. 1984 J. Biol. Chem. pmid:6480582
Arce V et al. The in vivo incorporation of acetate into different non-saponifiable lipids by neonatal chick tissues. 1984 Comp. Biochem. Physiol., B pmid:6478791
Miettinen TA Cholesterol and bile acid synthesis in two families with homozygous and heterozygous hypercholesterolemia. 1984 Jul-Aug Arteriosclerosis pmid:6466195
Bhavnani BR Oestrogen biosynthesis in the pregnant mare. 1981 J. Endocrinol. pmid:6453917
Strauss JS et al. The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. 1980 J. Invest. Dermatol. pmid:6444323
Chen HW and Leonard DA Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. 1984 J. Biol. Chem. pmid:6429139
Scott MT et al. Adjuvant requirements for protective immunization of mice using a Trypanosoma cruzi 90K cell surface glycoprotein. 1984 Int. Arch. Allergy Appl. Immunol. pmid:6429057
Richter E et al. Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane. 1983 Xenobiotica pmid:6415933
Takeuchi N et al. Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. 1978 Exp. Gerontol. pmid:639893
Wielgosz GJ and Armstrong DT Effects of prolactin, progesterone, and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat. 1978 Can. J. Physiol. Pharmacol. pmid:638868
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Ryder NS et al. Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. 1984 Antimicrob. Agents Chemother. pmid:6375557
Jahnke L and Klein HP Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae. 1983 J. Bacteriol. pmid:6348021
Pinto WJ et al. Stereochemically distinct roles for sterol in Saccharomyces cerevisiae. 1983 Biochem. Biophys. Res. Commun. pmid:6340686
Pinto WJ and Nes WR Stereochemical specificity for sterols in Saccharomyces cerevisiae. 1983 J. Biol. Chem. pmid:6339498
Tilvis RS et al. Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. 1978 Scand. J. Clin. Lab. Invest. pmid:628820
Bachman D et al. Effect of bacille Calmette-Guerin immunotherapy on feline sarcoma virus-induced neoplasms in the cat. 1982 Am. J. Vet. Res. pmid:6280529
Stewart ME et al. Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. 1984 J. Invest. Dermatol. pmid:6228612
Matsuo I et al. Mechanism of skin surface lipid peroxidation. 1983 Curr. Probl. Dermatol. pmid:6197240
Richter E et al. Excretion of beta-hexachlorocyclohexane by the rat as influenced by oral paraffin, squalane, and Lutrol E 400. 1981 Ecotoxicol. Environ. Saf. pmid:6170505
Lay JP et al. Metabolism of beta-hexachlorocyclohexane-14C in rats following low dosing in the daily diet. 1981 J Environ Sci Health B pmid:6166652