(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Simonen PP et al. | The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. | 2007 | Atherosclerosis | pmid:16963050 |
Lewis RW | The squalene content of atheromatous plaques. A re-examination. | 1975 Nov-Dec | Atherosclerosis | pmid:1201156 |
Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
Gylling H et al. | Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. | 1995 | Atherosclerosis | pmid:7669084 |
Corsini A et al. | Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. | 1993 | Atherosclerosis | pmid:8216498 |
Vanhanen HT and Miettinen TA | Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. | 1995 | Atherosclerosis | pmid:7661873 |
Rajaratnam RA et al. | Serum squalene in postmenopausal women without and with coronary artery disease. | 1999 | Atherosclerosis | pmid:10487487 |
Stefanovich V and Kajiyama G | Squalene and cholestanol in normal rabbit aorta. | 1970 May-Jun | Atherosclerosis | pmid:5433085 |
Mackay D and Jones PJ | Evaluation of methods for the determination of cholesterol absorption and synthesis in humans. | 2011 | Atherosclerosis | pmid:21763652 |
Miettinen TA and Gylling H | Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. | 2003 | Atherosclerosis | pmid:12801618 |
Jenkins DT et al. | Amniotic fluid squalene: a useful test in prolonged pregnancy. | 1982 | Aust N Z J Obstet Gynaecol | pmid:6959611 |
Douglas TJ et al. | Inhibition of cholesterol biosynthesis in ovine ovarian follicles in vitro by human chorionic gonadotrophin. | 1978 | Aust. J. Biol. Sci. | pmid:571711 |
Stone HD and Xie ZX | Efficacy of experimental Newcastle disease water-in-oil oil-emulsion vaccines formulated from squalane and squalene. | 1990 Oct-Dec | Avian Dis. | pmid:2149264 |
Kato S et al. | Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371265 |
Tornabene TG | Formation of hydrocarbons by bacteria and algae. | 1981 | Basic Life Sci. | pmid:7271715 |
Gloor M et al. | [Influence of skin surface lipids on the result of Burckhardt's alkali resistance determination]. | 1972 | Berufsdermatosen | pmid:4262349 |
Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
CARAVACA J et al. | Inhibition of squalene and cholesterol biosynthesis by hepatocatalase (Caperase). | 1963 | Biochem. Biophys. Res. Commun. | pmid:14018515 |
CORNFORTH JW et al. | Stereospecific insertion of hydrogen atom into squalene from reduced nicotinamide-adenine dinucleotides. | 1963 | Biochem. Biophys. Res. Commun. | pmid:14023096 |
Vidrine DW and Nicholas HJ | Squalene-2,3-epoxidase activity in rat brain during growth and maturation. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4842300 |