(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dracheva S et al. | Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. | 1996 | FEBS Lett. | pmid:8612754 |
Astruc M et al. | Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. | 1977 | Biochim. Biophys. Acta | pmid:857899 |
Ott G et al. | Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. | 1995 | Vaccine | pmid:8578842 |
Henk G and Heinz T | [Hydrocarbon content in the fat of meat pigs after feeding "Fermosin"]. | 1993 | Arch Tierernahr | pmid:8572916 |
Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
Airaudi D et al. | Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. | 1995 Jul-Aug | Mycoses | pmid:8559196 |
McKean ML and Nes WR | Delayed conversion of squalene to sterols during development of Pinus pinea seeds. | 1977 | Lipids | pmid:853880 |
Kohasi O et al. | Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D. | 1977 | Int. Arch. Allergy Appl. Immunol. | pmid:852904 |
Socaciu C et al. | In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:8521075 |
Horie M et al. | An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. | 1993 | Biochim. Biophys. Acta | pmid:8504141 |