(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Steatorrhea D045602 2 associated lipids
Fasciitis D005208 2 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Coronavirus Infections D018352 4 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Viremia D014766 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Fibrosarcoma D005354 8 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Fatigue D005221 10 associated lipids
Hepatitis D006505 11 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Influenza, Human D007251 11 associated lipids
Otitis Media D010033 12 associated lipids
Keloid D007627 12 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
Cholestasis D002779 23 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Arthritis D001168 41 associated lipids
Occupational Diseases D009784 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Parkinson Disease D010300 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
Alzheimer Disease D000544 76 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Weight Gain D015430 101 associated lipids
Inflammation D007249 119 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hemolysis D006461 131 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Morel S et al. Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity. 2011 Vaccine pmid:21256188
Decaro N et al. Immunogenicity and protective efficacy in dogs of an MF59â„¢-adjuvanted vaccine against recombinant canine/porcine coronavirus. 2011 Vaccine pmid:21272607
Singh M et al. A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens. 2006 Vaccine pmid:16300864
Puig-Barberà J et al. Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. 2004 Vaccine pmid:15530669
Del Giudice G et al. An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. 2006 Vaccine pmid:16464520
Barnett SW et al. Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. 1997 Vaccine pmid:9234536
Boyce TG et al. Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adults. 2000 Vaccine pmid:10930676
O'Hagan DT et al. Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1. 2000 Vaccine pmid:10699327
Keitel W et al. Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. 2010 Vaccine pmid:19835829
Vesikari T et al. MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination. 2009 Vaccine pmid:19840662
Precioso AR et al. A phase I randomized, double-blind, controlled trial of 2009 influenza A (H1N1) inactivated monovalent vaccines with different adjuvant systems. 2011 Vaccine pmid:21945258
Pariani E et al. Response to 2009 pandemic and seasonal influenza vaccines co-administered to HIV-infected and HIV-uninfected former drug users living in a rehabilitation community in Italy. 2011 Vaccine pmid:21974995
Andrews NJ et al. Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. 2011 Vaccine pmid:21875635
Iorio AM et al. Influenza viruses and cross-reactivity in healthy adults: humoral and cellular immunity induced by seasonal 2007/2008 influenza vaccination against vaccine antigens and 2009 A(H1N1) pandemic influenza virus. 2012 Vaccine pmid:22245606
Dupuis M et al. Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. 1999 Vaccine pmid:10519932
Heineman TC et al. A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant. 1999 Vaccine pmid:10438046
Tsai T et al. Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. 2010 Vaccine pmid:19969117
Pietrella D et al. A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. 2010 Vaccine pmid:20038431
Langley JM et al. Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study. 2012 Vaccine pmid:22469860
Fukase H et al. Assessment of the immunogenicity and safety of varying doses of an MF59®-adjuvanted cell culture-derived A/H1N1 pandemic influenza vaccine in Japanese paediatric, adult and elderly subjects. 2012 Vaccine pmid:22472791
Hatz C et al. A randomized clinical trial to identify the optimal antigen and MF59(®) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy adult and elderly subjects. 2012 Vaccine pmid:22446638
Della Cioppa G et al. Trivalent and quadrivalent MF59(®)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study. 2011 Vaccine pmid:21906647
Fox CB et al. Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. 2011 Vaccine pmid:21906648
Black S et al. Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis. 2010 Vaccine pmid:20813217
de Bruijn I et al. Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly. 2007 Vaccine pmid:18063446
Cristiani C et al. Safety of MF-59 adjuvanted vaccine for pandemic influenza: results of the vaccination campaign in an Italian health district. 2011 Vaccine pmid:21396903
Meier S et al. Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children. 2011 Vaccine pmid:21419775
Parretta E et al. Italian post-marketing surveillance for adverse event reports after MF59-adjuvanted H1N1v vaccination. 2011 Vaccine pmid:21406267
Van Buynder PG et al. The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly. 2013 Vaccine pmid:23933368
Vinay TN et al. Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus). 2013 Vaccine pmid:23896420
Poder A et al. An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. 2014 Vaccine pmid:24252703
Dediukhina EG and Eroshin VK [Hydrocarbon biosynthesis by microorganisms]. 1973 Nov-Dec Usp Sovrem Biol pmid:4593530
PerederiÄ­ OF and Morozova RP [Squalene and sterols of rat stomach tissue and the effect of acetylsalicylic acid on their content]. 1978 Nov-Dec Ukr. Biokhim. Zh. pmid:749299
Morozova RP et al. [Separation of lipid extract from animal blood and tissues and isolation of squalene and sterols from it]. 1982 Jul-Aug Ukr. Biokhim. Zh. pmid:7135500
Vendt VP [Studies in the field of chemistry, biochemistry and photobiochemistry of sterols]. 1975 Sep-Oct Ukr Biokhim Zh pmid:1105921
Sanina OL and Datsenko ZM [Sterol composition of sarcolemma in normal rabbits and in experimental muscular dystrophy]. 1975 Nov-Dec Ukr Biokhim Zh pmid:1202710
Ihara T [Evaluation of alum-adjuvanted whole virus influenza vaccine and future aspects of influenza A (H1N1) 2009 vaccine]. 2010 Uirusu pmid:20848866
Laursen AB [Dangerous adjuvant in swine influenza vaccine]. 2009 Ugeskr. Laeg. pmid:19866499
Bruun Laursen A [Catastrophic consequences of Pandemrix swine flu vaccine containing squalene]. 2013 Ugeskr. Laeg. pmid:23833781
Mølbak K [Squalene unlikely sinner]. 2013 Ugeskr. Laeg. pmid:23833782
Moebius FF et al. Genetic defects in postsqualene cholesterol biosynthesis. 2000 Trends Endocrinol. Metab. pmid:10707051
Siirtola A et al. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. 2006 Transplantation pmid:16477216
Gylling H et al. Cholesterol synthesis prevails over absorption in metabolic syndrome. 2007 Transl Res pmid:17543849
Johnson WS Nonenzymic biogenetic-like olefinic cyclizations. 1967 Trans N Y Acad Sci pmid:5237390
Sunthornandh P and Ratanabanangkoon K A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. 1994 Toxicon pmid:8079368
Kuroda Y et al. Distinctive patterns of autoimmune response induced by different types of mineral oil. 2004 Toxicol. Sci. pmid:14718649
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Uchino T et al. Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. 2004 Toxicol In Vitro pmid:15046771
Yockel S and Schatz GC Dynamic QM/MM: a hybrid approach to simulating gas-liquid interactions. 2012 Top Curr Chem pmid:21506003
Hayakawa K and Matsuo I Effects of PUVA therapy on skin surface lipids: skin surface lipid peroxidation in psoriasis vulgaris and its biological significance. 1986 Tokai J. Exp. Clin. Med. pmid:3672560
Chida N and Okamura T Increased cholesterol-biosynthesis in familial hypercholesterolemia. 1971 Tohoku J. Exp. Med. pmid:5140375
Torinuki W et al. Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. 1982 Tohoku J. Exp. Med. pmid:7101278
Ali HM et al. Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. 2014 Thyroid pmid:23885719
Miettinen TA Hyperlipoproteinemia--relation to platelet lipids, platelet function and tendency to thrombosis. 1974 Thromb. Res. pmid:4367389
Alghisi F et al. Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis. 2011 Thorax pmid:21228426
Achiraman S et al. Increased squalene concentrations in the clitoral gland during the estrous cycle in rats: an estrus-indicating scent mark? 2011 Theriogenology pmid:21924481
Montana M et al. Safety review: squalene and thimerosal in vaccines. 2010 Nov-Dec Therapie pmid:21176760
Dorea JG Safety of thimerosal in vaccines: for whom and how many doses? 2011 Mar-Apr Therapie pmid:23189333
Corey EJ and Yamamoto H Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. 1970 Tetrahedron Lett. pmid:5447652
Rees HH et al. Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. 1968 Tetrahedron Lett. pmid:5640097
Abe I [Bioorganic chemistry of squalene cyclase]. 1994 Tanpakushitsu Kakusan Koso pmid:8090933
Yamamoto S [Oxidative cyclization of squalene. Biosynthesis of sterols]. 1970 Tanpakushitsu Kakusan Koso pmid:4912088
Dennick RG The intracellular organisation of cholesterol biosynthesis. A review. 1972 Steroids Lipids Res pmid:4572325
Van Leusden H and Villee CA The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. 1965 Steroids pmid:5857495
Cattel L et al. Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase. 1989 Mar-May Steroids pmid:2678608
Nitchuk WM and Ainsworth L The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. 1972 Steroids pmid:5028884
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
Giera M et al. Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway. 2007 Steroids pmid:17583759
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Dean PD The cyclases of triterpene and sterol biosynthesis. 1971 Steroidologia pmid:5004310
Couvreur P et al. Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. 2008 Small pmid:18247384
Chiba K et al. Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784064
Zouboulis CC et al. Culture of human sebocytes and markers of sebocytic differentiation in vitro. 1991 Skin Pharmacol. pmid:1715175
Wohlrab J et al. Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine. 2010 Skin Pharmacol Physiol pmid:20523109
Ekanayake-Mudiyanselage S et al. Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids. 2005 Jan-Feb Skin Pharmacol Physiol pmid:15608499
Cornforth JW Asymmetry and enzyme action. 1976 Science pmid:935862
Edmond J et al. Mevalonate metabolism: role of kidneys. 1976 Science pmid:935865
Blumer M Hydrocarbons in digestive tract and liver of a basking shark. 1967 Science pmid:5609822
Wendt KU et al. Structure and function of a squalene cyclase. 1997 Science pmid:9295270
Graebe JE Isoprenoid biosynthesis in a cell-free system from pea shoots. 1967 Science pmid:4381746
Crispino GA et al. Selective perhydroxylation of squalene: taming the arithmetic demon. 1993 Science pmid:8418495
Hayaishi O and Nozaki M Nature and mechanisms of oxygenases. 1969 Science pmid:4304952
McLaren L et al. Dense-gas chromatography of nonvolatile substances of high molecular weight. 1968 Science pmid:5634909
Giddings JC et al. High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. 1968 Science pmid:5675186
De Souza NJ and Nes WR Sterols: isolation from a blue-green alga. 1968 Science pmid:5677529
Maugh TH Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. 1982 Science pmid:7146911
Sherman DR et al. Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. 1992 Science pmid:1470914
Del Giudice G et al. Seasonal influenza vaccine provides priming for A/H1N1 immunization. 2009 Sci Transl Med pmid:20371459
Khurana S et al. Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. 2010 Sci Transl Med pmid:20371470
Pollard AJ and Hill AV Antibody repertoire: embracing diversity. 2011 Sci Transl Med pmid:21795586
Khurana S et al. MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. 2011 Sci Transl Med pmid:21632986
Tsai TF et al. Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. 2011 Scand. J. Infect. Dis. pmid:21534891
Strandberg TE et al. Squalene and sterol synthesis in isolated small-intestinal cells of the rat. 1981 Scand. J. Gastroenterol. pmid:7323711
Tilvis RS et al. Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. 1978 Scand. J. Clin. Lab. Invest. pmid:628820
Koivisto PV and Miettinen TA Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. 1988 Scand. J. Clin. Lab. Invest. pmid:3217753
Miettinen TA and Tilvis R Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. 1981 Scand. J. Clin. Lab. Invest. pmid:7313530
Linares A et al. Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. 1984 Rev. Esp. Fisiol. pmid:6531508
VILLALBA GOMEZ GM [Squalene index]. 1956 May-Aug Rev Sanid Asist Soc pmid:13379961
Allison AC and Byars NE Syntex adjuvant formulation. 1992 Res. Immunol. pmid:1439132
Dillard CJ et al. Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. 1982 Res. Commun. Chem. Pathol. Pharmacol. pmid:7122999