(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Villee CA et al. | The regulation of the biosynthesis of sterols and steroids in the placenta. | 1966 | Adv. Enzyme Regul. | pmid:4862939 |
Kim SK and Karadeniz F | Biological importance and applications of squalene and squalane. | 2012 | Adv. Food Nutr. Res. | pmid:22361190 |
Beck FW and Whitehouse MW | Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. | 1976 | Agents Actions | pmid:822699 |
Pregliasco F et al. | Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly. | 2001 | Aging (Milano) | pmid:11292151 |
Kajaste-Rudnitski A et al. | Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals. | 2011 | AIDS | pmid:21150561 |
Durier C et al. | Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults. | 2013 | AIDS | pmid:23018437 |
Keefer MC et al. | Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8744579 |
Ohkawa S et al. | Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. | 1994 | AIDS Res. Hum. Retroviruses | pmid:8179961 |
Vajdy M et al. | Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. | 2004 | AIDS Res. Hum. Retroviruses | pmid:15588349 |
Kelly GS | Squalene and its potential clinical uses. | 1999 | Altern Med Rev | pmid:9988781 |
Waterman E and Lockwood B | Active components and clinical applications of olive oil. | 2007 | Altern Med Rev | pmid:18069902 |
DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
Miettinen TA et al. | Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism. | 1987 | Am. Heart J. | pmid:3812207 |
Newmark HL | Is oleic acid or squalene the important preventive agent? | 2000 | Am. J. Clin. Nutr. | pmid:10919949 |
Downing DT et al. | Changes in skin surface lipid composition induced by severe caloric restriction in man. | 1972 | Am. J. Clin. Nutr. | pmid:5010536 |
Miettinen TA and Vanhanen H | Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. | 1994 | Am. J. Clin. Nutr. | pmid:8310985 |
Strauss JS et al. | Surface lipid composition in children with protein-calorie malnutrition. | 1978 | Am. J. Clin. Nutr. | pmid:414616 |
Villa M et al. | Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. | 2013 | Am. J. Epidemiol. | pmid:23863759 |
Mannino S et al. | Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy. | 2012 | Am. J. Epidemiol. | pmid:22940713 |
Skowronski DM et al. | Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". | 2013 | Am. J. Epidemiol. | pmid:23436898 |