(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ginger ML et al. | Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. | 1999 | Biochem. J. | pmid:10455027 |
De Donato S et al. | Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly. | 1999 | Vaccine | pmid:10462245 |
Yoder JA et al. | Squalene: a naturally abundant mammalian skin secretion and long distance tick-attractant (Acari: Ixodidae). | 1999 | J. Med. Entomol. | pmid:10467784 |
Milla P et al. | 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. | 1999 | Lipids | pmid:10478925 |
Rajaratnam RA et al. | Serum squalene in postmenopausal women without and with coronary artery disease. | 1999 | Atherosclerosis | pmid:10487487 |
Dupuis M et al. | Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. | 1999 | Vaccine | pmid:10519932 |
Lee JY et al. | Squalene-induced extrinsic lipoid pneumonia: serial radiologic findings in nine patients. | 1999 Sep-Oct | J Comput Assist Tomogr | pmid:10524857 |
Allison AC | Squalene and squalane emulsions as adjuvants. | 1999 | Methods | pmid:10525443 |
Zhang L et al. | The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. | 1999 | Immunology | pmid:10540226 |
Psomiadou E and Tsimidou M | On the role of squalene in olive oil stability. | 1999 | J. Agric. Food Chem. | pmid:10552760 |
Thiele JJ et al. | Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. | 1999 | J. Invest. Dermatol. | pmid:10594744 |
Chiba K et al. | Skin roughness and wrinkle formation induced by repeated application of squalene-monohydroperoxide to the hairless mouse. | 1999 | Exp. Dermatol. | pmid:10597136 |
Kawada A et al. | In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. | 1999 | Photodermatol Photoimmunol Photomed | pmid:10599972 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Okada S et al. | Molecular characterization of squalene synthase from the green microalga Botryococcus braunii, race B. | 2000 | Arch. Biochem. Biophys. | pmid:10620354 |
Hoshino T et al. | New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10635573 |
Asa PB et al. | Antibodies to squalene in Gulf War syndrome. | 2000 | Exp. Mol. Pathol. | pmid:10640454 |
Laden BP et al. | Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10666321 |
Newmark HL | Squalene, olive oil, and cancer risk. Review and hypothesis. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668494 |
Hamilton JA et al. | Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1. | 2000 | J. Leukoc. Biol. | pmid:10670584 |