(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jones JP et al. | Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. | 1975 | J. Neurochem. | pmid:1110355 |
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Tansey TR and Shechter I | Structure and regulation of mammalian squalene synthase. | 2000 | Biochim. Biophys. Acta | pmid:11111077 |
Greer CE et al. | The comparison of the effect of LTR72 and MF59 adjuvants on mouse humoral response to intranasal immunisation with human papillomavirus type 6b (HPV-6b) virus-like particles. | 2000 | Vaccine | pmid:11137233 |
Toh TH et al. | Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry. | 2001 | Anal. Biochem. | pmid:11141305 |
Yamada Y et al. | Oxidative degradation of squalene by Arthrobacter species. | 1975 | Appl Microbiol | pmid:1115507 |
Safe S and Caldwell J | The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii. | 1975 | Can. J. Microbiol. | pmid:1116039 |
GarcÃa-Román N et al. | Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. | 2001 | Mol. Cell. Neurosci. | pmid:11178870 |
Harro CD et al. | Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. | 2001 | J. Natl. Cancer Inst. | pmid:11181775 |
Colombatti M and Dosio F | Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immunotoxins. | 2001 | Methods Mol. Biol. | pmid:11217376 |
Thiele JJ et al. | The antioxidant network of the stratum corneum. | 2001 | Curr. Probl. Dermatol. | pmid:11225199 |
Shibata N et al. | Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226224 |
Voogt PA et al. | What about squalene in the earthworm Lumbricus terrestris? | 1975 | Comp. Biochem. Physiol., B | pmid:1122731 |
Cunningham CK et al. | Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women. | 2001 | Clin. Infect. Dis. | pmid:11229849 |
Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
Buckner FS et al. | Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors. | 2001 | Antimicrob. Agents Chemother. | pmid:11257036 |
Podda A | The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine. | 2001 | Vaccine | pmid:11257408 |
Pregliasco F et al. | Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly. | 2001 | Aging (Milano) | pmid:11292151 |
Blader IJ et al. | Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. | 2001 | J. Biol. Chem. | pmid:11294868 |
Ruiz-Gutiérrez V et al. | Detection of squalene in alpha-fetoprotein and fetal serum albumin from bovine. | 2001 | J. Protein Chem. | pmid:11330344 |