(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Van Leusden H and Villee CA | The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. | 1965 | Steroids | pmid:5857495 |
GOODWIN TW and WILLIAMS RJ | A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. | 1965 | Biochem. J. | pmid:14342248 |
SHORB MS et al. | EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14277681 |
NUSBAUM-CASSUTO E and VILLOUTREIX J | [DEMONSTRATION OF LYCOPERSENE IN HIGHER PLANTS]. | 1965 | C. R. Hebd. Seances Acad. Sci. | pmid:14287016 |
NICHOLAS HJ and BOMBAUGH KJ | CONSTITUENTS OF THE HYDROCARBON FRACTION OF BEEF BRAINS. | 1965 | Biochim. Biophys. Acta | pmid:14320231 |
CAPSTACKE JR et al. | SQUALENE IN PISUM SATIVUM. ITS CYCLIZATION TO BETA-AMYRIN AND LABELING PATTERN. | 1965 | J. Biol. Chem. | pmid:14321361 |
HELLIG HR and SAVARD K | BIOSYNTHESIS OF PROGESTERONE, STEROLS, AND SQUALENE FROM ACETATE-1-14-C AND MEVALONATE-2-14-C BY THE BOVINE CORPUS LUTEUM IN VITRO. | 1965 | J. Biol. Chem. | pmid:14299614 |
Gosselin L and Duvivier J | [On the utilization of C14-2-mevalonic acid by cell fractions of bovine adrenal gland homogenates]. | 1965 | Arch. Int. Physiol. Biochim. | pmid:4158100 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379289 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379291 |
Blondin GA et al. | The biosynthesis of squalene and sterols in fish. | 1966 | Comp. Biochem. Physiol. | pmid:4380202 |
Krishna G et al. | Enzymic conversion of farnesyl pyrophosphate to squalene. | 1966 | Arch. Biochem. Biophys. | pmid:4380977 |
Akhtar M et al. | The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol. | 1966 | Biochem. J. | pmid:4381706 |
Cory EJ et al. | 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. | 1966 | J. Am. Chem. Soc. | pmid:5918046 |
Corey EJ and Russey WE | Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. | 1966 | J. Am. Chem. Soc. | pmid:5918047 |
Van Tamelen EE et al. | Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. | 1966 | J. Am. Chem. Soc. | pmid:5918048 |
Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
Hsia SL et al. | Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. | 1966 | J. Invest. Dermatol. | pmid:5924299 |
Butterworth PH et al. | In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. | 1966 | Arch. Biochem. Biophys. | pmid:5944963 |
Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |