(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Simon SA et al. | The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. | 1977 | Biophys. J. | pmid:880329 |
Gloor M and Kohler H | A contribution to a new test method for dandruff-inhibiting and "keratolytic" action of drugs. | 1977 | Eur. J. Clin. Pharmacol. | pmid:880976 |
Mark M et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820110 |
Bonté F et al. | Simarouba amara extract increases human skin keratinocyte differentiation. | 1996 | J Ethnopharmacol | pmid:8844461 |
Ferguson JB and Bloch K | Purification and properties of a soluble protein activator of rat liver squalene epoxidase. | 1977 | J. Biol. Chem. | pmid:885856 |
Dogliotti M et al. | Nutritional influences of pellagra on sebum composition. | 1977 | Br. J. Dermatol. | pmid:889695 |
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Fujie T et al. | Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. | 1996 | Arch. Dermatol. Res. | pmid:8931874 |
Grimes DS et al. | Sunlight, cholesterol and coronary heart disease. | 1996 | QJM | pmid:8935479 |
Traquina P et al. | MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. | 1996 | J. Infect. Dis. | pmid:8940205 |
Krisans SK | Cell compartmentalization of cholesterol biosynthesis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993542 |
Stach D et al. | Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. | 1997 | J. Med. Chem. | pmid:9003518 |
Nikkilä K et al. | Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. | 1996 | J. Lipid Res. | pmid:9017519 |
BeytÃa ED and Porter JW | Biochemistry of polyisoprenoid biosynthesis. | 1976 | Annu. Rev. Biochem. | pmid:9026 |
Downing DT et al. | The time course of lipid formation in human sebaceous glands. | 1977 | J. Invest. Dermatol. | pmid:903669 |
Baum CL et al. | Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. | 1997 | J. Biol. Chem. | pmid:9045674 |
O'Hagan DT et al. | Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. | 1997 | Mol Med Today | pmid:9060004 |
Kushiro T et al. | In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. | 1997 | Biol. Pharm. Bull. | pmid:9084891 |
Eisele B et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. | 1997 | J. Lipid Res. | pmid:9101437 |