(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crispino GA et al. | Selective perhydroxylation of squalene: taming the arithmetic demon. | 1993 | Science | pmid:8418495 |
| Gloor M and Karenfeld A | Effect of ultraviolet light therapy, given over a period of several weeks, on the amount and composition of the skin surface lipids. | 1977 | Dermatologica | pmid:844642 |
| Asnis DS et al. | Shark oil pneumonia. An overlooked entity. | 1993 | Chest | pmid:8449116 |
| Balliano G et al. | Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene. | 1993 | FEBS Lett. | pmid:8462686 |
| Seo S et al. | Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. | 1993 | Steroids | pmid:8484187 |
| Prashad M | Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. | 1993 | J. Med. Chem. | pmid:8496942 |
| Horie M et al. | An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. | 1993 | Biochim. Biophys. Acta | pmid:8504141 |
| Socaciu C et al. | In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:8521075 |
| Kohasi O et al. | Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D. | 1977 | Int. Arch. Allergy Appl. Immunol. | pmid:852904 |
| McKean ML and Nes WR | Delayed conversion of squalene to sterols during development of Pinus pinea seeds. | 1977 | Lipids | pmid:853880 |
| Airaudi D et al. | Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. | 1995 Jul-Aug | Mycoses | pmid:8559196 |
| Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
| Henk G and Heinz T | [Hydrocarbon content in the fat of meat pigs after feeding "Fermosin"]. | 1993 | Arch Tierernahr | pmid:8572916 |
| Ott G et al. | Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. | 1995 | Vaccine | pmid:8578842 |
| Astruc M et al. | Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. | 1977 | Biochim. Biophys. Acta | pmid:857899 |
| Dracheva S et al. | Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. | 1996 | FEBS Lett. | pmid:8612754 |
| Ito T et al. | Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. | 1996 | Gastroenterology | pmid:8613070 |
| Yoshino S | Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. | 1996 | Biomed. Pharmacother. | pmid:8672728 |
| Barth MM et al. | Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. | 1996 | J. Med. Chem. | pmid:8691425 |
| Fan SR et al. | Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. | 1996 | Mutat. Res. | pmid:8692222 |
| Yamada Y et al. | Oxidation of linear terpenes and squalene variants by Arthrobacter sp. | 1977 | Appl. Environ. Microbiol. | pmid:869527 |
| Fogelman AM et al. | Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. | 1977 | Biochem. Biophys. Res. Commun. | pmid:869944 |
| Gylling H et al. | The metabolism of cholestanol in primary biliary cirrhosis. | 1996 | J. Hepatol. | pmid:8738731 |
| Chan P et al. | Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. | 1996 | J Clin Pharmacol | pmid:8739021 |
| Lakshmanan MR and Veech RL | Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. | 1977 | J. Biol. Chem. | pmid:873910 |
| Keefer MC et al. | Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8744579 |
| Arthington-Skaggs BA et al. | Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. | 1996 | FEBS Lett. | pmid:8772195 |
| Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
| Higgins DA et al. | MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. | 1996 | Vaccine | pmid:8782343 |
| Airaudi D et al. | In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. | 1996 Jan-Feb | Mycoses | pmid:8786759 |
| Piretti MV et al. | Simultaneous reversed-phase high-performance liquid chromatographic separation of non-polar isoprenoid lipids and their determination. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8788146 |
| Simon SA et al. | The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. | 1977 | Biophys. J. | pmid:880329 |
| Gloor M and Kohler H | A contribution to a new test method for dandruff-inhibiting and "keratolytic" action of drugs. | 1977 | Eur. J. Clin. Pharmacol. | pmid:880976 |
| Mark M et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820110 |
| Bonté F et al. | Simarouba amara extract increases human skin keratinocyte differentiation. | 1996 | J Ethnopharmacol | pmid:8844461 |
| Ferguson JB and Bloch K | Purification and properties of a soluble protein activator of rat liver squalene epoxidase. | 1977 | J. Biol. Chem. | pmid:885856 |
| Dogliotti M et al. | Nutritional influences of pellagra on sebum composition. | 1977 | Br. J. Dermatol. | pmid:889695 |
| Kohashi O et al. | Effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains. | 1977 | Infect. Immun. | pmid:892904 |
| Fujie T et al. | Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. | 1996 | Arch. Dermatol. Res. | pmid:8931874 |
| Grimes DS et al. | Sunlight, cholesterol and coronary heart disease. | 1996 | QJM | pmid:8935479 |
| Traquina P et al. | MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. | 1996 | J. Infect. Dis. | pmid:8940205 |
| Krisans SK | Cell compartmentalization of cholesterol biosynthesis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993542 |
| Stach D et al. | Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. | 1997 | J. Med. Chem. | pmid:9003518 |
| Nikkilä K et al. | Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. | 1996 | J. Lipid Res. | pmid:9017519 |
| BeytÃa ED and Porter JW | Biochemistry of polyisoprenoid biosynthesis. | 1976 | Annu. Rev. Biochem. | pmid:9026 |
| Downing DT et al. | The time course of lipid formation in human sebaceous glands. | 1977 | J. Invest. Dermatol. | pmid:903669 |
| Baum CL et al. | Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. | 1997 | J. Biol. Chem. | pmid:9045674 |
| O'Hagan DT et al. | Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. | 1997 | Mol Med Today | pmid:9060004 |
| Kushiro T et al. | In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. | 1997 | Biol. Pharm. Bull. | pmid:9084891 |
| Eisele B et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. | 1997 | J. Lipid Res. | pmid:9101437 |