(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rangel H et al. | Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. | 1996 | Antimicrob. Agents Chemother. | pmid:9124841 |
| Gylling H et al. | Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. | 1996 | Atherosclerosis | pmid:9125314 |
| Granoff DM et al. | MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. | 1997 | Infect. Immun. | pmid:9125551 |
| Kawakami T et al. | Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. | 1997 | Clin. Orthop. Relat. Res. | pmid:9137198 |
| Perzl M et al. | Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. | 1997 | Microbiology (Reading, Engl.) | pmid:9141686 |
| Wiss O and Wiss V | On metabolic degradations of squalene, lanosterol and cholesterol in rat liver in vivo. Evidence for recycling of metabolites for the synthesis of isoprene compounds. | 1977 | Helv. Chim. Acta | pmid:914630 |
| Morand OH et al. | Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. | 1997 | J. Lipid Res. | pmid:9162756 |
| Kuchta T et al. | Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. | 1997 | FEMS Microbiol. Lett. | pmid:9163904 |
| Fliesler SJ et al. | Squalene is localized to the plasma membrane in bovine retinal rod outer segments. | 1997 | Exp. Eye Res. | pmid:9176062 |
| Flint OP et al. | Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221828 |
| Barnett SW et al. | Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. | 1997 | Vaccine | pmid:9234536 |
| Cenedella RJ | Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. | 1997 | Exp. Eye Res. | pmid:9237866 |
| Hamdan JS and Casali AK | Effect of amphotericin B on the lipids of yeast cells of Sporothrix schenckii. | 1996-1997 | Mycopathologia | pmid:9276941 |
| Donald KA et al. | Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. | 1997 | Appl. Environ. Microbiol. | pmid:9292983 |
| Wendt KU et al. | Structure and function of a squalene cyclase. | 1997 | Science | pmid:9295270 |
| Uusitupa MI et al. | Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran. | 1997 | Eur J Clin Nutr | pmid:9306087 |
| Grieveson LA et al. | A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene. | 1997 | Anal. Biochem. | pmid:9324936 |
| Mansfield PD et al. | The effects of four, commercial ceruminolytic agents on the middle ear. | 1997 Nov-Dec | J Am Anim Hosp Assoc | pmid:9358414 |
| Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
| Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
| Kribii R et al. | Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. | 1997 | Eur. J. Biochem. | pmid:9363754 |
| Cataldo DM and Van Nest G | The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. | 1997 | Vaccine | pmid:9364672 |
| Tomasi M et al. | Strong mucosal adjuvanticity of cholera toxin within lipid particles of a new multiple emulsion delivery system for oral immunization. | 1997 | Eur. J. Immunol. | pmid:9368632 |
| Salamon Z et al. | Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties. | 1997 | Biophys. J. | pmid:9370473 |
| Toews AD et al. | Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. | 1997 | Brain Res. Mol. Brain Res. | pmid:9387870 |
| Gloor M et al. | Biochemical and physiological parameters on the healthy skin surface of patients with common warts. | 1976 | Dermatologica | pmid:939341 |
| Law S et al. | Skin surface lipids inhibit adherence of Candida albicans to stratum corneum. | 1997 | Dermatology (Basel) | pmid:9407165 |
| Newmark HL | Squalene, olive oil, and cancer risk: a review and hypothesis. | 1997 | Cancer Epidemiol. Biomarkers Prev. | pmid:9419410 |
| Ceruti M et al. | 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. | 1998 | J. Med. Chem. | pmid:9484504 |
| Rao CV et al. | Chemopreventive effect of squalene on colon cancer. | 1998 | Carcinogenesis | pmid:9498278 |
| O'Hagan DT | Recent advances in vaccine adjuvants for systemic and mucosal administration. | 1998 | J. Pharm. Pharmacol. | pmid:9504429 |
| Lopez D et al. | Compensatory responses to inhibition of hepatic squalene synthase. | 1998 | Arch. Biochem. Biophys. | pmid:9514656 |
| Basáñez G et al. | Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. | 1998 | Biochemistry | pmid:9521711 |
| Stoskopf MK et al. | The impact of water temperature on core body temperature of North American river otters (Lutra canadensis) during simulated oil spill recovery washing protocols. | 1997 | J. Zoo Wildl. Med. | pmid:9523634 |
| Sato T et al. | Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9532806 |
| Zheng YF et al. | Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. | 1998 | Biochemistry | pmid:9558334 |
| Saat YA and Bloch KE | Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. | 1976 | J. Biol. Chem. | pmid:956181 |
| Smith TJ et al. | Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. | 1998 | Carcinogenesis | pmid:9600360 |
| Sajbidor J et al. | Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. | 1998 | J. Pharm. Pharmacol. | pmid:9600722 |
| Patt TE and Hanson RS | Intracytoplasmic membrane, phospholipid, and sterol content of Methylobacterium organophilum cells grown under different conditions. | 1978 | J. Bacteriol. | pmid:96093 |
| Dupuis M et al. | Dendritic cells internalize vaccine adjuvant after intramuscular injection. | 1998 | Cell. Immunol. | pmid:9637761 |
| Srikantaiah MV et al. | Purification and properties of sterol carrier protein1. | 1976 | J. Biol. Chem. | pmid:965373 |
| Hagiwara T et al. | Determination of lycopene, alpha-carotene and beta-carotene in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry with selected-ion monitoring. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9653948 |
| Nakano M et al. | Useful 1O2 (1delta g) generator, 3-(4'-methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO), for dioxygenation of squalence (a skin surface lipid) in an organic solvent and bacterial killing in aqueous medium. | 1998 | FEBS Lett. | pmid:9710240 |
| Perzl M et al. | Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. | 1998 | Biochim. Biophys. Acta | pmid:9714766 |
| Nesburn AB et al. | Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. | 1998 | J. Virol. | pmid:9733807 |
| Grabowski GA et al. | Evidence for carrier proteins in bile acid synthesis. The effect of squalene and sterol carrier protein and albumin on the activity of 12alpha-hydroxylase. | 1976 | Biochim. Biophys. Acta | pmid:974090 |
| Weldon MK et al. | Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro. | 1998 | J. Lipid Res. | pmid:9741703 |
| Kushiro T et al. | Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. | 1998 | Eur. J. Biochem. | pmid:9746369 |
| Joshi MK et al. | Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin. | 1998 | Biochemistry | pmid:9772173 |