(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Van Leusden H and Villee CA | The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. | 1965 | Steroids | pmid:5857495 |
Kipping D | [Observations on skin surface fats]. | 1965 | Z Haut Geschlechtskr | pmid:5860995 |
SHORB MS et al. | EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14277681 |
NUSBAUM-CASSUTO E and VILLOUTREIX J | [DEMONSTRATION OF LYCOPERSENE IN HIGHER PLANTS]. | 1965 | C. R. Hebd. Seances Acad. Sci. | pmid:14287016 |
NICHOLAS HJ and BOMBAUGH KJ | CONSTITUENTS OF THE HYDROCARBON FRACTION OF BEEF BRAINS. | 1965 | Biochim. Biophys. Acta | pmid:14320231 |
CAPSTACKE JR et al. | SQUALENE IN PISUM SATIVUM. ITS CYCLIZATION TO BETA-AMYRIN AND LABELING PATTERN. | 1965 | J. Biol. Chem. | pmid:14321361 |
HELLIG HR and SAVARD K | BIOSYNTHESIS OF PROGESTERONE, STEROLS, AND SQUALENE FROM ACETATE-1-14-C AND MEVALONATE-2-14-C BY THE BOVINE CORPUS LUTEUM IN VITRO. | 1965 | J. Biol. Chem. | pmid:14299614 |
Gosselin L and Duvivier J | [On the utilization of C14-2-mevalonic acid by cell fractions of bovine adrenal gland homogenates]. | 1965 | Arch. Int. Physiol. Biochim. | pmid:4158100 |
Krishna G et al. | Enzymic conversion of farnesyl pyrophosphate to squalene. | 1966 | Arch. Biochem. Biophys. | pmid:4380977 |
Akhtar M et al. | The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol. | 1966 | Biochem. J. | pmid:4381706 |
Villee CA et al. | The regulation of the biosynthesis of sterols and steroids in the placenta. | 1966 | Adv. Enzyme Regul. | pmid:4862939 |
Rilling HC | A new intermediate in the biosynthesis of squalene. | 1966 | J. Biol. Chem. | pmid:4287912 |
Gaylor JL et al. | Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. | 1966 | J. Lipid Res. | pmid:4290536 |
Ismail AA et al. | Interrelation between thyroid hormones and essential fatty acids. | 1966 | Acta Physiol Acad Sci Hung | pmid:5953398 |
Zelewski L and Villee CA | The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta. | 1966 | Biochemistry | pmid:5963423 |
Butterworth PH et al. | In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. | 1966 | Arch. Biochem. Biophys. | pmid:5944963 |
Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |
Brooks CJ et al. | Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. | 1966 | Biochim. Biophys. Acta | pmid:5973204 |
Van Tamelen EE et al. | Nonenzymic laboratory cyclization of squalene 2,3-oxide. | 1966 | J. Am. Chem. Soc. | pmid:5980879 |
Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |