(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Richter E and Schäfer SG | Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice. | 1982 | J Environ Sci Health B | pmid:7096897 |
Richter E and Schäfer SG | The effect of squalane on the absorption of dietary cholesterol by the rat. | 1982 | Res Exp Med (Berl) | pmid:7100640 |
Torinuki W et al. | Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. | 1982 | Tohoku J. Exp. Med. | pmid:7101278 |
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Emmons GT et al. | Effects of 20,25-diazacholesterol on cholesterol synthesis in cultured chick muscle cells: a radiogas chromatographic and mass spectrometric study of the post-squalene sector. | 1982 | Biomed. Mass Spectrom. | pmid:7126761 |
Richter E et al. | Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. | 1982 | Chem. Biol. Interact. | pmid:7083398 |
Maugh TH | Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. | 1982 | Science | pmid:7146911 |
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Morin RJ and Srikantaiah MV | Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds. | 1982 | Pharmacol Res Commun | pmid:7156175 |
Bell FP and Hubert EV | Stimulation of hepatic squalene and triglyceride synthesis by dimethylsulfoxide, in vitro. | 1982 | Lipids | pmid:7162368 |
Bird S and Gower DB | Axillary 5 alpha-androst-16-en-3-one, cholesterol and squalene in men; preliminary evidence for 5 alpha-androst-16-en-3-one being a product of bacterial action. | 1982 | J. Steroid Biochem. | pmid:7176644 |
Morozova RP et al. | [Separation of lipid extract from animal blood and tissues and isolation of squalene and sterols from it]. | 1982 Jul-Aug | Ukr. Biokhim. Zh. | pmid:7135500 |
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Kajiyama G et al. | Serum squalene in patients with gallstones. | 1983 | Hiroshima J. Med. Sci. | pmid:6618897 |
Strandberg TE | Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo. | 1983 | Lipids | pmid:6621260 |
Zaaijer D and van der Horst CJ | Cyclic changes in hormones, carbohydrates and indole metabolism in cervical mucus of normal, fertilizing cows and the relationship with non-fertility. | 1983 | Cytobios | pmid:6684538 |
Bell FP and Hubert EV | Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. | 1983 | Lipids | pmid:6633175 |
Rahier A et al. | Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. | 1983 | Biochem. Soc. Trans. | pmid:6642064 |
Aguilera JA et al. | Incorporation of mevalonate into squalene, lanosterol and cholesterol by different neonatal chick tissues. | 1983 | Int. J. Biochem. | pmid:6653866 |
Matsuo I et al. | Mechanism of skin surface lipid peroxidation. | 1983 | Curr. Probl. Dermatol. | pmid:6197240 |
Tilvis RS and Miettinen TA | Dietary squalene increases tissue sterols and fecal bile acids in the rat. | 1983 | Lipids | pmid:6835033 |
Crilly JF and Earnshaw JC | Photon correlation spectroscopy of bilayer lipid membranes. | 1983 | Biophys. J. | pmid:6838962 |
Fuks-Holmberg D and Bloch K | Intermembrane transfer of squalene promoted by supernatant protein factor. | 1983 | J. Lipid Res. | pmid:6854149 |
Tilvis RS and Miettinen TA | Absorption and metabolic fate of dietary 3H-squalene in the rat. | 1983 | Lipids | pmid:6855483 |
Tanio Y et al. | Regression of line-10 hepatocarcinoma with synthetic quinonyl muramyl dipeptide in strain-2 guinea pigs. | 1983 | Gan | pmid:6862142 |
Ohkuma T et al. | Intensification of host's immunity by squalene in sarcoma 180 bearing ICR mice. | 1983 | J. Pharmacobio-dyn. | pmid:6864440 |
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Jahnke L and Klein HP | Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae. | 1983 | J. Bacteriol. | pmid:6348021 |
Richter E et al. | Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane. | 1983 | Xenobiotica | pmid:6415933 |
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Linares A et al. | Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. | 1984 | Rev. Esp. Fisiol. | pmid:6531508 |
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Miettinen TA | Cholesterol and bile acid synthesis in two families with homozygous and heterozygous hypercholesterolemia. | 1984 Jul-Aug | Arteriosclerosis | pmid:6466195 |
Nakagawa M et al. | Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor. | 1985 | Jpn. J. Cancer Res. | pmid:2408954 |
Anderson DG | Gorgosterol biosynthesis: localization of squalene formation in the zooxanthellar component of various gorgonians. | 1985 | Comp. Biochem. Physiol., B | pmid:2861942 |
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Gower DB et al. | Axillary 5 alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. | 1985 | Experientia | pmid:4043321 |
Yamanishi Y et al. | Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis. | 1985 | Gastroenterol. Jpn. | pmid:4043657 |
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