(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lorenz RT and Parks LW | Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast. | 1987 | J. Bacteriol. | pmid:3301810 |
Aguilera JA et al. | Age-related changes in the mevalonate metabolism in vivo in chick kidneys. | 1988 | Arch. Int. Physiol. Biochim. | pmid:2460056 |
Raederstorff D and Rohmer M | Polyterpenoids as cholesterol and tetrahymanol surrogates in the ciliate Tetrahymena pyriformis. | 1988 | Biochim. Biophys. Acta | pmid:3130105 |
Keller RK and Simonet WS | Near normal levels of isoprenoid lipids in severe mevalonic aciduria. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3365255 |
Nishimura S | [Fasting serum squalene in patients with gallstones and hyperlipidemia]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3385962 |
Marco de la Calle C and Gibbons GF | Hepatic and intestinal formation of polar sterols in vivo in animals fed on a cholesterol-supplemented diet. | 1988 | Biochem. J. | pmid:3415662 |
Stein RA and Mead JF | Small hydrocarbons formed by the peroxidation of squalene. | 1988 | Chem. Phys. Lipids | pmid:3342456 |
Färkkilä MA et al. | Raised plasma cholesterol precursors in patients with gut resections. | 1988 | Gut | pmid:3345929 |
Masihi KN et al. | Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion. | 1988 | J. Chromatogr. | pmid:3042798 |
Koivisto PV and Miettinen TA | Increased amounts of cholesterol precursors in lipoproteins after ileal exclusion. | 1988 | Lipids | pmid:3200122 |
Sasiak K and Rilling HC | Purification to homogeneity and some properties of squalene synthetase. | 1988 | Arch. Biochem. Biophys. | pmid:3277535 |
Balliano G et al. | Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives. | 1988 | Biochim. Biophys. Acta | pmid:3278744 |
Buttke TM et al. | Regulation of squalene epoxidase activity by membrane fatty acid composition in yeast. | 1988 | Lipids | pmid:3280941 |
Koivisto PV and Miettinen TA | Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. | 1988 | Scand. J. Clin. Lab. Invest. | pmid:3217753 |
Kohno T and Ohnishi Y | [Histopathology of meibomian gland abnormalities in experimental PenCB intoxicated beagle treated with squalane]. | 1989 | Fukuoka Igaku Zasshi | pmid:2501191 |
Hashiguchi I et al. | [Histological study on the gingiva in PenCB poisoned beagle dogs]. | 1989 | Fukuoka Igaku Zasshi | pmid:2501192 |
Panini SR et al. | Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. | 1989 | J. Biol. Chem. | pmid:2567731 |
Morita T et al. | Inhibitory effect of a new mycotic agent, piritetrate on ergosterol biosynthesis in pathogenic fungi. | 1989 | J. Med. Vet. Mycol. | pmid:2666631 |
Bortz JT et al. | The origin of alkanes found in human skin surface lipids. | 1989 | J. Invest. Dermatol. | pmid:2584738 |
Strandberg TE et al. | Effects of cholestyramine and squalene feeding on hepatic and serum plant sterols in the rat. | 1989 | Lipids | pmid:2586228 |
Heinemann SH and Sigworth FJ | Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. | 1989 | Biochim. Biophys. Acta | pmid:2480817 |
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Matsuo I et al. | Possible involvement of oxidation of lipids in inducing griseofulvin photosensitivity. | 1990 | Photodermatol Photoimmunol Photomed | pmid:2091745 |
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Strandberg TE et al. | Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. | 1990 | J. Lipid Res. | pmid:2246614 |
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Ochs D et al. | Properties of purified squalene-hopene cyclase from Bacillus acidocaldarius. | 1990 | Eur. J. Biochem. | pmid:2253626 |
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Palamarchuk VI | [Characteristics of the radiation-induced changes in the content of sterols and squalene in the lymphoid system tissues and erythrocyte membranes of rats]. | 1990 May-Jun | Radiobiologiia | pmid:2371389 |
Stone HD and Xie ZX | Efficacy of experimental Newcastle disease water-in-oil oil-emulsion vaccines formulated from squalane and squalene. | 1990 Oct-Dec | Avian Dis. | pmid:2149264 |
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Allison AC and Byars NE | Immunological adjuvants: desirable properties and side-effects. | 1991 | Mol. Immunol. | pmid:1850114 |
Horie M et al. | Hypolipidemic effects of NB-598 in dogs. | 1991 | Atherosclerosis | pmid:1892485 |
Picardo M et al. | Squalene peroxides may contribute to ultraviolet light-induced immunological effects. | 1991 | Photodermatol Photoimmunol Photomed | pmid:1804289 |
Rickman LS et al. | Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine. | 1991 | Lancet | pmid:1673211 |
Gylling H et al. | Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. | 1991 | Metab. Clin. Exp. | pmid:1984567 |
Kamimura H et al. | [Studies on distribution and excretion of squalane in dogs administered for 2 weeks]. | 1991 | Fukuoka Igaku Zasshi | pmid:1916603 |
Elnaiem DA et al. | Chemical factors controlling oviposition of Lutzomyia longipalpis (Diptera: Psychodidae). | 1991 | Parassitologia | pmid:1841210 |
Wagner-Recio M et al. | Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. | 1991 | J. Neurochem. | pmid:1940905 |