(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Balliano G et al. | Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene. | 1993 | FEBS Lett. | pmid:8462686 |
Crispino GA et al. | Selective perhydroxylation of squalene: taming the arithmetic demon. | 1993 | Science | pmid:8418495 |
Asnis DS et al. | Shark oil pneumonia. An overlooked entity. | 1993 | Chest | pmid:8449116 |
Henk G and Heinz T | [Hydrocarbon content in the fat of meat pigs after feeding "Fermosin"]. | 1993 | Arch Tierernahr | pmid:8572916 |
Prashad M | Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. | 1993 | J. Med. Chem. | pmid:8496942 |
Horie M et al. | An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. | 1993 | Biochim. Biophys. Acta | pmid:8504141 |
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Hilgers LA et al. | A novel non-mineral oil-based adjuvant. I. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in laboratory animals. | 1994 | Vaccine | pmid:8085385 |
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Wieland B et al. | Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus. | 1994 | J. Bacteriol. | pmid:8002598 |
Byars NE et al. | Vaccinating guinea pigs with recombinant glycoprotein D of herpes simplex virus in an efficacious adjuvant formulation elicits protection against vaginal infection. | 1994 | Vaccine | pmid:8165851 |
Dollis D and Schuber F | Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. | 1994 | Biochem. Pharmacol. | pmid:8043030 |
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Abe I | [Bioorganic chemistry of squalene cyclase]. | 1994 | Tanpakushitsu Kakusan Koso | pmid:8090933 |
Pogliani L et al. | An NMR and molecular mechanics study of squalene and squalene derivatives. | 1994 | Chem. Phys. Lipids | pmid:8013054 |
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Domnas A et al. | Squalene metabolism in two species of Lagenidium. | 1994 | Can. J. Microbiol. | pmid:8076247 |
Sunthornandh P and Ratanabanangkoon K | A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. | 1994 | Toxicon | pmid:8079368 |
Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
Mookhtiar KA et al. | Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. | 1994 | J. Biol. Chem. | pmid:8157649 |
Florin-Christensen M et al. | Occurrence of specific sterols in Pneumocystis carinii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8292026 |
Miettinen TA and Vanhanen H | Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. | 1994 | Am. J. Clin. Nutr. | pmid:8310985 |
Inoue H et al. | Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8179579 |
Ohkawa S et al. | Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. | 1994 | AIDS Res. Hum. Retroviruses | pmid:8179961 |
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Gylling H et al. | Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. | 1995 | Atherosclerosis | pmid:7669084 |
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Socaciu C et al. | In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:8521075 |
Boutaud O et al. | Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7887959 |
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Gylling H et al. | Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. | 1996 | Atherosclerosis | pmid:9125314 |
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Grimes DS et al. | Sunlight, cholesterol and coronary heart disease. | 1996 | QJM | pmid:8935479 |
Krisans SK | Cell compartmentalization of cholesterol biosynthesis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993542 |
Nikkilä K et al. | Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. | 1996 | J. Lipid Res. | pmid:9017519 |
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Dracheva S et al. | Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. | 1996 | FEBS Lett. | pmid:8612754 |
Ito T et al. | Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. | 1996 | Gastroenterology | pmid:8613070 |
Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
Higgins DA et al. | MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. | 1996 | Vaccine | pmid:8782343 |
Mark M et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820110 |
Arthington-Skaggs BA et al. | Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. | 1996 | FEBS Lett. | pmid:8772195 |