(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vendt VP | [Studies in the field of chemistry, biochemistry and photobiochemistry of sterols]. | 1975 Sep-Oct | Ukr Biokhim Zh | pmid:1105921 |
Dang T and Prestwich GD | Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. | 2000 | Chem. Biol. | pmid:11048954 |
Matyas GR et al. | Induction and detection of antibodies to squalene. | 2000 | J. Immunol. Methods | pmid:11042279 |
Matthan NR et al. | Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women. | 2000 | Lipids | pmid:11026626 |
Bartfai E et al. | [Studies on the genotoxic effects of crude liver oils from 3 species of Mediterranean sharks by means of in vitro micronucleus test using human lymphocytes]. | 2000 Sep-Oct | Ann. Biol. Clin. (Paris) | pmid:11022102 |
Berekaa MM and Steinbüchel A | Microbial degradation of the multiply branched alkane 2,6,10,15,19, 23-hexamethyltetracosane (Squalane) by Mycobacterium fortuitum and Mycobacterium ratisbonense. | 2000 | Appl. Environ. Microbiol. | pmid:11010899 |
Moreau JP et al. | Biosynthesis of sterols by a yeast homogenate. Incorporation of mevalonic acid into cholesta-5,7,24-trien-3beta-ol and 5alpha-cholesta-7,24-dien-3beta-ol. | 1975 | Eur. J. Biochem. | pmid:1100393 |
Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
Giacomoni PU et al. | Aging of human skin: review of a mechanistic model and first experimental data. | 2000 | IUBMB Life | pmid:10995026 |
Barton DH et al. | Investigations on the biosynthesis of steroids and terpenoids. Part XII. Biosynthesis of 3beta-hydroxy-triterpenoids and -steroids from (3S)-2,3-epoxy-2,3-dihydrosqualene. | 1975 | J. Chem. Soc. Perkin Trans. I | pmid:1099108 |