(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sarpietro MG et al. | Synthesis of n-squalenoyl cytarabine and evaluation of its affinity with phospholipid bilayers and monolayers. | 2011 | Int J Pharm | pmid:21219999 |
Brasser AJ et al. | Presence of wax esters and squalene in human saliva. | 2011 | Arch. Oral Biol. | pmid:21247555 |
Arguedas A et al. | Assessment of the safety, tolerability and kinetics of the immune response to A/H1N1v vaccine formulations with and without adjuvant in healthy pediatric subjects from 3 through 17 years of age. | 2011 | Hum Vaccin | pmid:21285531 |
Manuel O et al. | Humoral response to the influenza A H1N1/09 monovalent AS03-adjuvanted vaccine in immunocompromised patients. | 2011 | Clin. Infect. Dis. | pmid:21288852 |
Alghisi F et al. | Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis. | 2011 | Thorax | pmid:21228426 |
Decaro N et al. | Immunogenicity and protective efficacy in dogs of an MF59â„¢-adjuvanted vaccine against recombinant canine/porcine coronavirus. | 2011 | Vaccine | pmid:21272607 |
Pariani E et al. | Response to 2009 pandemic and seasonal influenza vaccines co-administered to HIV-infected and HIV-uninfected former drug users living in a rehabilitation community in Italy. | 2011 | Vaccine | pmid:21974995 |
Andrews NJ et al. | Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. | 2011 | Vaccine | pmid:21875635 |
Vesikari T et al. | Oil-in-water emulsion adjuvant with influenza vaccine in young children. | 2011 | N. Engl. J. Med. | pmid:21995388 |
Niehaus TD et al. | Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21746901 |
Oliaro-Bosso S et al. | Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | 2011 | PLoS ONE | pmid:21811565 |
Bildstein L et al. | Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes. | 2011 | Eur J Pharm Biopharm | pmid:21784150 |
Della Cioppa G et al. | Trivalent and quadrivalent MF59(®)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study. | 2011 | Vaccine | pmid:21906647 |
Fox CB et al. | Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. | 2011 | Vaccine | pmid:21906648 |
Zuccotti GV et al. | Long-lasting immunogenicity and safety of a 2009 pandemic influenza A(H1N1) MF59-adjuvanted vaccine when co-administered with a 2009-2010 seasonal influenza vaccine in young patients with type 1 diabetes mellitus. | 2011 | Diabet. Med. | pmid:21916971 |
Meyer K et al. | A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infection. | 2011 | PLoS ONE | pmid:21887300 |
Broeders NE et al. | Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study. | 2011 | Clin J Am Soc Nephrol | pmid:21921153 |
Weyermann C et al. | Initial results on the composition of fingerprints and its evolution as a function of time by GC/MS analysis. | 2011 | J. Forensic Sci. | pmid:20707835 |
Sun Y et al. | A reproducible in-vivo model of lymphatic malformation in rats. | 2011 | J. Comp. Pathol. | pmid:21419420 |
Meier S et al. | Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children. | 2011 | Vaccine | pmid:21419775 |
Réjiba S et al. | Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. | 2011 | Nanomedicine | pmid:21419876 |
Banzhoff A et al. | Passive surveillance of adverse events of an MF59-adjuvanted H1N1v vaccine during the pandemic mass vaccinations. | 2011 | Hum Vaccin | pmid:21422814 |
Parretta E et al. | Italian post-marketing surveillance for adverse event reports after MF59-adjuvanted H1N1v vaccination. | 2011 | Vaccine | pmid:21406267 |
Ambike A et al. | Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane. | 2011 | Langmuir | pmid:21413743 |
Montana M et al. | Safety review: squalene and thimerosal in vaccines. | 2010 Nov-Dec | Therapie | pmid:21176760 |
Smentek L and Hess BA | Compelling computational evidence for the concerted cyclization of the ABC rings of hopene from protonated squalene. | 2010 | J. Am. Chem. Soc. | pmid:21080653 |
Fragapane E et al. | A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly. | 2010 | Clin. Vaccine Immunol. | pmid:20810680 |
Esposito S et al. | Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major. | 2010 | Vaccine | pmid:20888873 |
Ansaldi F et al. | Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates. | 2010 | Vaccine | pmid:20433807 |
Pili B et al. | Interaction of a new anticancer prodrug, gemcitabine-squalene, with a model membrane: coupled DSC and XRD study. | 2010 | Biochim. Biophys. Acta | pmid:20435013 |
Gylling H et al. | Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study. | 2010 | J. Lipid Res. | pmid:20436182 |
Chen G et al. | Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. | 2010 | N Biotechnol | pmid:20412873 |
Xiao L et al. | The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. | 2010 | Biomaterials | pmid:20488530 |
Carmona A et al. | Immunogenicity and safety of AS03-adjuvanted 2009 influenza A H1N1 vaccine in children 6-35 months. | 2010 | Vaccine | pmid:20600478 |
Caligiani A et al. | Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction. | 2010 | Plant Foods Hum Nutr | pmid:20607413 |
Zhao RY et al. | Cloning and characterization of squalene synthase gene from Fusarium fujikuroi (Saw.) Wr. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20585832 |
De Luca C and Valacchi G | Surface lipids as multifunctional mediators of skin responses to environmental stimuli. | 2010 | Mediators Inflamm. | pmid:20981292 |
Tsuchiya M et al. | Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. | 2010 | Endocrinology | pmid:20685866 |
Camilloni B et al. | An influenza B outbreak during the 2007/2008 winter among appropriately immunized elderly people living in a nursing home. | 2010 | Vaccine | pmid:20846530 |
Ihara T | [Evaluation of alum-adjuvanted whole virus influenza vaccine and future aspects of influenza A (H1N1) 2009 vaccine]. | 2010 | Uirusu | pmid:20848866 |
Sere YY et al. | A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein. | 2010 | Free Radic. Biol. Med. | pmid:20850523 |
Vesikari T et al. | Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. | 2010 | Pediatrics | pmid:20819892 |
Pili B et al. | Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. | 2010 | Nanoscale | pmid:20820745 |
Camera E et al. | Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry. | 2010 | J. Lipid Res. | pmid:20719760 |
Watanabe T et al. | Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20728352 |
Ray R et al. | Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins. | 2010 | J. Infect. Dis. | pmid:20677942 |
Nováková Z et al. | Effects of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor pravastatin on membrane lipids and membrane associated functions of Methanothermobacter thermautotrophicus. | 2010 | Folia Microbiol. (Praha) | pmid:20680571 |
Bate J et al. | Immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer in the United Kingdom. | 2010 | Clin. Infect. Dis. | pmid:21067352 |
Madhun AS et al. | An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. | 2010 | Vaccine | pmid:21034828 |
Kato S et al. | Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics. | 2010 | J Nanosci Nanotechnol | pmid:21137794 |