(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |
Bowden PE et al. | Effects of 5alpha-reduced androgens on preputial-gland size and lipogenic activity. | 1976 | Biochem. Soc. Trans. | pmid:1001770 |
Cooper MF et al. | Effects of testosterone and alpha-melanocyte-stimulating hormone on preputial-gland (sebaceous) activity. | 1976 | Biochem. Soc. Trans. | pmid:1001771 |
Takeuchi M et al. | Corynebacterium terpenotabidum sp. nov., a bacterium capable of degrading squalene. | 1999 | Int. J. Syst. Bacteriol. | pmid:10028267 |
Gajkowska B et al. | The experimental squalene encephaloneuropathy in the rat. | 1999 | Exp. Toxicol. Pathol. | pmid:10048717 |
Volkov GL et al. | [In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. | 1976 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:1005362 |
Barchfeld GL et al. | The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. | 1999 | Vaccine | pmid:10067675 |
Verschoor EJ et al. | Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. | 1999 | J. Virol. | pmid:10074183 |
Gloor M et al. | Biochemical and physiological parameters on the healthy skin surface of persons with candidal intertrigo and of persons with tinea cruris. | 1976 | Arch Dermatol Res | pmid:1008615 |
Lee JS et al. | Exogenous lipoid pneumonia: high-resolution CT findings. | 1999 | Eur Radiol | pmid:10101652 |
Bouissou H et al. | [Cutaneous cholesterol and phospholipids in atherosclerosis]. | 1976 | Paroi Arterielle | pmid:1012738 |
Weeks OB and Francesconi MD | Occurrence of squalene and sterols in Cellulomonas dehydrogenans (Arnaudi 1942) comb. nov. Hester 1971. | 1978 | J. Bacteriol. | pmid:101527 |
O'Neill HJ and Gershbein LL | Lipids of human and equine smegma. | 1976 | Oncology | pmid:1018879 |
Fitzky BU et al. | Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism. | 1999 | Curr. Opin. Lipidol. | pmid:10327280 |
Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
Yamawaki M et al. | Antitumor activity of squalene-treated cell-wall skeleton of Nocardia rubra in mice. | 1978 | Gan | pmid:103768 |
Rajaratnam RA et al. | Impaired postprandial clearance of squalene and apolipoprotein B-48 in post-menopausal women with coronary artery disease. | 1999 | Clin. Sci. | pmid:10409473 |
Heineman TC et al. | A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant. | 1999 | Vaccine | pmid:10438046 |
Kalinowski SS and Mookhtiar KA | Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors. | 1999 | Arch. Biochem. Biophys. | pmid:10441385 |
Copado MA et al. | Fatty acids and squalene carried by alpha fetoprotein, and fetal and adult serum albumin from chicken. Comparison with these from mammals. | 1999 | J. Protein Chem. | pmid:10449039 |
Ginger ML et al. | Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. | 1999 | Biochem. J. | pmid:10455027 |
De Donato S et al. | Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly. | 1999 | Vaccine | pmid:10462245 |
Yoder JA et al. | Squalene: a naturally abundant mammalian skin secretion and long distance tick-attractant (Acari: Ixodidae). | 1999 | J. Med. Entomol. | pmid:10467784 |
Milla P et al. | 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. | 1999 | Lipids | pmid:10478925 |
Rajaratnam RA et al. | Serum squalene in postmenopausal women without and with coronary artery disease. | 1999 | Atherosclerosis | pmid:10487487 |
Dupuis M et al. | Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. | 1999 | Vaccine | pmid:10519932 |
Lee JY et al. | Squalene-induced extrinsic lipoid pneumonia: serial radiologic findings in nine patients. | 1999 Sep-Oct | J Comput Assist Tomogr | pmid:10524857 |
Allison AC | Squalene and squalane emulsions as adjuvants. | 1999 | Methods | pmid:10525443 |
Zhang L et al. | The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. | 1999 | Immunology | pmid:10540226 |
Psomiadou E and Tsimidou M | On the role of squalene in olive oil stability. | 1999 | J. Agric. Food Chem. | pmid:10552760 |
Thiele JJ et al. | Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. | 1999 | J. Invest. Dermatol. | pmid:10594744 |
Chiba K et al. | Skin roughness and wrinkle formation induced by repeated application of squalene-monohydroperoxide to the hairless mouse. | 1999 | Exp. Dermatol. | pmid:10597136 |
Kawada A et al. | In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. | 1999 | Photodermatol Photoimmunol Photomed | pmid:10599972 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Okada S et al. | Molecular characterization of squalene synthase from the green microalga Botryococcus braunii, race B. | 2000 | Arch. Biochem. Biophys. | pmid:10620354 |
Hoshino T et al. | New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10635573 |
Asa PB et al. | Antibodies to squalene in Gulf War syndrome. | 2000 | Exp. Mol. Pathol. | pmid:10640454 |
Laden BP et al. | Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10666321 |
Newmark HL | Squalene, olive oil, and cancer risk. Review and hypothesis. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668494 |
Hamilton JA et al. | Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1. | 2000 | J. Leukoc. Biol. | pmid:10670584 |
Radisky ES and Poulter CD | Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. | 2000 | Biochemistry | pmid:10677224 |
Sporn MB and Suh N | Chemoprevention of cancer. | 2000 | Carcinogenesis | pmid:10688873 |
O'Hagan DT et al. | Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1. | 2000 | Vaccine | pmid:10699327 |
Moebius FF et al. | Genetic defects in postsqualene cholesterol biosynthesis. | 2000 | Trends Endocrinol. Metab. | pmid:10707051 |
Drulak MW et al. | Vaccination of seropositive subjects with CHIRON CMV gB subunit vaccine combined with MF59 adjuvant for production of CMV immune globulin. | 2000 | Viral Immunol. | pmid:10733168 |
Rajaratnam RA et al. | Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. | 2000 | J. Am. Coll. Cardiol. | pmid:10758959 |
Relas H et al. | Effect of stanol ester on postabsorptive squalene and retinyl palmitate. | 2000 | Metab. Clin. Exp. | pmid:10778871 |
Viola F et al. | Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase. | 2000 | Lipids | pmid:10783007 |
Alving CR and Grabenstein JD | Re: Antibodies to squalene in Gulf War Syndrome. | 2000 | Exp. Mol. Pathol. | pmid:10816387 |
Rhodes CJ et al. | "Spin-labelling" with the second hydrogen radioisotope: radicals formed from squalene by muonium addition. | 2000 | Free Radic. Res. | pmid:10826923 |