(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kelley MT et al. | Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. | 1969 | J. Lipid Res. | pmid:4305711 |
Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
Hayaishi O and Nozaki M | Nature and mechanisms of oxygenases. | 1969 | Science | pmid:4304952 |
Akhtar M et al. | The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. | 1969 | Biochem. J. | pmid:5343788 |
Gershbein LL and Singh EJ | Hydrocarbons of dogfish and cod livers and herring oil. | 1969 | J Am Oil Chem Soc | pmid:5345048 |
Downing DT et al. | Variability in the chemical composition of human skin surface lipids. | 1969 | J. Invest. Dermatol. | pmid:5347411 |
Partin JC and Schubert WK | Small intestinal mucosa in cholesterol ester storage disease. A light and electron microscope study. | 1969 | Gastroenterology | pmid:5348089 |
Tornabene TG et al. | Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. | 1969 | J. Lipid Res. | pmid:5785002 |
Porcellati G et al. | Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. | 1969 | Lipids | pmid:5785689 |
Boyd GS and Onajobi FD | Control of cholesterol biosynthesis by a plasma apo-lipoprotein. | 1969 | Nature | pmid:5789314 |
Saxena SC and Zandee DI | Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. | 1969 | Arch. Int. Physiol. Biochim. | pmid:4188405 |
Yamamoto S and Bloch K | On the enzymes catalysing the transformation of squalene to lanosterol. | 1969 | Biochem. J. | pmid:5807185 |
Higgins MJ and Kekwick RG | The role of malonyl-coenzyme A in isoprenoid biosynthesis. | 1969 | Biochem. J. | pmid:5807201 |
Frayha GJ | A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). | 1968 | Comp. Biochem. Physiol. | pmid:5710286 |
Suzue G et al. | Presence of squalene in Staphylococcus. | 1968 | Arch. Biochem. Biophys. | pmid:5650319 |
Dempsey ME | Inhibition of lipid biosynthesis. | 1968 | Ann. N. Y. Acad. Sci. | pmid:4385358 |
Scallen TJ et al. | Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. | 1968 | J. Biol. Chem. | pmid:4386511 |
Lofland HB et al. | Atherosclerosis in Cebus monkeys. II. Arterial metabolism. | 1968 | Exp. Mol. Pathol. | pmid:4969998 |
Cornforth JW | Olefin alkylation in biosynthesis. | 1968 | Angew. Chem. Int. Ed. Engl. | pmid:4976264 |
Sih CJ and Whitlock HW | Biochemistry of steroids. | 1968 | Annu. Rev. Biochem. | pmid:4875723 |
Rees HH et al. | Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. | 1968 | Biochem. J. | pmid:4297048 |
Jollow D et al. | The biogenesis of mitochondria. 3. The lipid composition of aerobically and anaerobically grown Saccharomyces cerevisiae as related to the membrane systems of the cells. | 1968 | J. Cell Biol. | pmid:4297785 |
Shafai T and Lewin LM | Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. | 1968 | Biochim. Biophys. Acta | pmid:4298231 |
McLaren L et al. | Dense-gas chromatography of nonvolatile substances of high molecular weight. | 1968 | Science | pmid:5634909 |
Chorbanian AV | Sterol synthesis in the human arterial intima. | 1968 | J. Clin. Invest. | pmid:5637146 |
Clayton RB et al. | The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide. | 1968 | J. Am. Chem. Soc. | pmid:5638313 |
Rees HH et al. | The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. | 1968 | Biochem. J. | pmid:5639923 |
Rees HH et al. | Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. | 1968 | Tetrahedron Lett. | pmid:5640097 |
Aaronson S and Fulco L | Effect of hypocholesteremic compounds on bacterial multiplication. | 1968 | J. Gen. Microbiol. | pmid:5640227 |
Chesterton CJ | Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. | 1968 | J. Biol. Chem. | pmid:5646164 |
St Clair RW et al. | Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. | 1968 | Exp. Mol. Pathol. | pmid:5647248 |
Scallen TJ et al. | Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. | 1968 | Biochem. Biophys. Res. Commun. | pmid:5653642 |
Dada OA et al. | Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. | 1968 | Eur. J. Biochem. | pmid:5653765 |
Wepierre J et al. | Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. | 1968 | Eur. J. Pharmacol. | pmid:5654669 |
Locke DC | Chromatographic study of solutions of hydrocarbons in acetonitrile. | 1968 | J. Chromatogr. | pmid:5656425 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. | 1968 | Arch. Int. Physiol. Biochim. | pmid:4178041 |
Bighi C et al. | Interpretation of gas chromatographic data. Hydrocarbons and aromatic compounds on Carbowax 400. | 1968 | J. Chromatogr. | pmid:5658564 |
Giddings JC et al. | High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. | 1968 | Science | pmid:5675186 |
De Souza NJ and Nes WR | Sterols: isolation from a blue-green alga. | 1968 | Science | pmid:5677529 |
White HB et al. | The occurrence of squalene in kipid of fowlpox virus. | 1968 | J. Biol. Chem. | pmid:5684008 |
Godtfredsen WO et al. | Biosynthesis of fusidic acid from squalene 2,3-oxide. | 1968 | J. Am. Chem. Soc. | pmid:5688690 |
Scharf SS and Simpson KL | Attempts to detect lycopersene formation in yeast. | 1968 | Biochem. J. | pmid:5753091 |
Merdinger E et al. | Composition of lipids in extracts of Pullularia pullulans. | 1968 | Can. J. Microbiol. | pmid:5693067 |
Caspi E et al. | The biosynthesis of tetrahymanol in vitro. | 1968 | Biochem. J. | pmid:5696872 |
Ackman RG et al. | Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. | 1968 | Nature | pmid:5701840 |
Conner RL et al. | Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. | 1968 | J. Protozool. | pmid:5703082 |
Suzuki R | Specific requirements of bile salts for absorption of cholesterol from the intestine. | 1968 | Keio J Med | pmid:5715537 |
Mukherjee S and Bhose A | Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. | 1968 | Biochim. Biophys. Acta | pmid:5721032 |
Threlfall DR et al. | Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. | 1968 | Biochem. J. | pmid:5721452 |
Autrum H et al. | [Squalene in the glandular secretion of mammals]. | 1968 | Naturwissenschaften | pmid:5726004 |