(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Otitis Media D010033 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Coronary Disease D003327 70 associated lipids
Acne Vulgaris D000152 35 associated lipids
Occupational Diseases D009784 42 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Fibrosarcoma D005354 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Cholestasis D002779 23 associated lipids
Olfaction Disorders D000857 17 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hepatitis D006505 11 associated lipids
Cholelithiasis D002769 16 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Hyperlipidemias D006949 73 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Parkinson Disease D010300 53 associated lipids
Celiac Disease D002446 16 associated lipids
Keloid D007627 12 associated lipids
Influenza, Human D007251 11 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Xanthomatosis D014973 17 associated lipids
Atherosclerosis D050197 85 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Fatigue D005221 10 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Rosacea D012393 13 associated lipids
Parasitemia D018512 5 associated lipids
Lipodystrophy D008060 4 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Tinea Versicolor D014010 5 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Chronic Disease D002908 7 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Viremia D014766 4 associated lipids
Alopecia Areata D000506 6 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Fasciitis D005208 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Steatorrhea D045602 2 associated lipids
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Kelley MT et al. Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. 1969 J. Lipid Res. pmid:4305711
Sofer SS and Rilling HC Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. 1969 J. Lipid Res. pmid:4305712
Hayaishi O and Nozaki M Nature and mechanisms of oxygenases. 1969 Science pmid:4304952
Akhtar M et al. The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. 1969 Biochem. J. pmid:5343788
Gershbein LL and Singh EJ Hydrocarbons of dogfish and cod livers and herring oil. 1969 J Am Oil Chem Soc pmid:5345048
Downing DT et al. Variability in the chemical composition of human skin surface lipids. 1969 J. Invest. Dermatol. pmid:5347411
Partin JC and Schubert WK Small intestinal mucosa in cholesterol ester storage disease. A light and electron microscope study. 1969 Gastroenterology pmid:5348089
Tornabene TG et al. Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. 1969 J. Lipid Res. pmid:5785002
Porcellati G et al. Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. 1969 Lipids pmid:5785689
Boyd GS and Onajobi FD Control of cholesterol biosynthesis by a plasma apo-lipoprotein. 1969 Nature pmid:5789314
Saxena SC and Zandee DI Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. 1969 Arch. Int. Physiol. Biochim. pmid:4188405
Yamamoto S and Bloch K On the enzymes catalysing the transformation of squalene to lanosterol. 1969 Biochem. J. pmid:5807185
Higgins MJ and Kekwick RG The role of malonyl-coenzyme A in isoprenoid biosynthesis. 1969 Biochem. J. pmid:5807201
Frayha GJ A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). 1968 Comp. Biochem. Physiol. pmid:5710286
Suzue G et al. Presence of squalene in Staphylococcus. 1968 Arch. Biochem. Biophys. pmid:5650319
Dempsey ME Inhibition of lipid biosynthesis. 1968 Ann. N. Y. Acad. Sci. pmid:4385358
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 J. Biol. Chem. pmid:4386511
Lofland HB et al. Atherosclerosis in Cebus monkeys. II. Arterial metabolism. 1968 Exp. Mol. Pathol. pmid:4969998
Cornforth JW Olefin alkylation in biosynthesis. 1968 Angew. Chem. Int. Ed. Engl. pmid:4976264
Sih CJ and Whitlock HW Biochemistry of steroids. 1968 Annu. Rev. Biochem. pmid:4875723
Rees HH et al. Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. 1968 Biochem. J. pmid:4297048
Jollow D et al. The biogenesis of mitochondria. 3. The lipid composition of aerobically and anaerobically grown Saccharomyces cerevisiae as related to the membrane systems of the cells. 1968 J. Cell Biol. pmid:4297785
Shafai T and Lewin LM Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. 1968 Biochim. Biophys. Acta pmid:4298231
McLaren L et al. Dense-gas chromatography of nonvolatile substances of high molecular weight. 1968 Science pmid:5634909
Chorbanian AV Sterol synthesis in the human arterial intima. 1968 J. Clin. Invest. pmid:5637146
Clayton RB et al. The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide. 1968 J. Am. Chem. Soc. pmid:5638313
Rees HH et al. The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. 1968 Biochem. J. pmid:5639923
Rees HH et al. Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. 1968 Tetrahedron Lett. pmid:5640097
Aaronson S and Fulco L Effect of hypocholesteremic compounds on bacterial multiplication. 1968 J. Gen. Microbiol. pmid:5640227
Chesterton CJ Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. 1968 J. Biol. Chem. pmid:5646164
St Clair RW et al. Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. 1968 Exp. Mol. Pathol. pmid:5647248
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 Biochem. Biophys. Res. Commun. pmid:5653642
Dada OA et al. Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. 1968 Eur. J. Biochem. pmid:5653765
Wepierre J et al. Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. 1968 Eur. J. Pharmacol. pmid:5654669
Locke DC Chromatographic study of solutions of hydrocarbons in acetonitrile. 1968 J. Chromatogr. pmid:5656425
Voogt PA Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. 1968 Arch. Int. Physiol. Biochim. pmid:4178041
Bighi C et al. Interpretation of gas chromatographic data. Hydrocarbons and aromatic compounds on Carbowax 400. 1968 J. Chromatogr. pmid:5658564
Giddings JC et al. High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. 1968 Science pmid:5675186
De Souza NJ and Nes WR Sterols: isolation from a blue-green alga. 1968 Science pmid:5677529
White HB et al. The occurrence of squalene in kipid of fowlpox virus. 1968 J. Biol. Chem. pmid:5684008
Godtfredsen WO et al. Biosynthesis of fusidic acid from squalene 2,3-oxide. 1968 J. Am. Chem. Soc. pmid:5688690
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091
Merdinger E et al. Composition of lipids in extracts of Pullularia pullulans. 1968 Can. J. Microbiol. pmid:5693067
Caspi E et al. The biosynthesis of tetrahymanol in vitro. 1968 Biochem. J. pmid:5696872
Ackman RG et al. Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. 1968 Nature pmid:5701840
Conner RL et al. Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. 1968 J. Protozool. pmid:5703082
Suzuki R Specific requirements of bile salts for absorption of cholesterol from the intestine. 1968 Keio J Med pmid:5715537
Mukherjee S and Bhose A Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. 1968 Biochim. Biophys. Acta pmid:5721032
Threlfall DR et al. Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. 1968 Biochem. J. pmid:5721452
Autrum H et al. [Squalene in the glandular secretion of mammals]. 1968 Naturwissenschaften pmid:5726004