(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yamawaki M et al. | Antitumor activity of squalene-treated cell-wall skeleton of Nocardia rubra in mice. | 1978 | Gan | pmid:103768 |
Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
Fitzky BU et al. | Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism. | 1999 | Curr. Opin. Lipidol. | pmid:10327280 |
O'Neill HJ and Gershbein LL | Lipids of human and equine smegma. | 1976 | Oncology | pmid:1018879 |
Weeks OB and Francesconi MD | Occurrence of squalene and sterols in Cellulomonas dehydrogenans (Arnaudi 1942) comb. nov. Hester 1971. | 1978 | J. Bacteriol. | pmid:101527 |
Bouissou H et al. | [Cutaneous cholesterol and phospholipids in atherosclerosis]. | 1976 | Paroi Arterielle | pmid:1012738 |
Lee JS et al. | Exogenous lipoid pneumonia: high-resolution CT findings. | 1999 | Eur Radiol | pmid:10101652 |
Gloor M et al. | Biochemical and physiological parameters on the healthy skin surface of persons with candidal intertrigo and of persons with tinea cruris. | 1976 | Arch Dermatol Res | pmid:1008615 |
Verschoor EJ et al. | Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. | 1999 | J. Virol. | pmid:10074183 |
Barchfeld GL et al. | The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. | 1999 | Vaccine | pmid:10067675 |
Volkov GL et al. | [In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. | 1976 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:1005362 |
Gajkowska B et al. | The experimental squalene encephaloneuropathy in the rat. | 1999 | Exp. Toxicol. Pathol. | pmid:10048717 |
Takeuchi M et al. | Corynebacterium terpenotabidum sp. nov., a bacterium capable of degrading squalene. | 1999 | Int. J. Syst. Bacteriol. | pmid:10028267 |
Cooper MF et al. | Effects of testosterone and alpha-melanocyte-stimulating hormone on preputial-gland (sebaceous) activity. | 1976 | Biochem. Soc. Trans. | pmid:1001771 |
Bowden PE et al. | Effects of 5alpha-reduced androgens on preputial-gland size and lipogenic activity. | 1976 | Biochem. Soc. Trans. | pmid:1001770 |
Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |