(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dediukhina EG and Eroshin VK | [Hydrocarbon biosynthesis by microorganisms]. | 1973 Nov-Dec | Usp Sovrem Biol | pmid:4593530 |
Sondergaard E et al. | Alimentary production of gallstones in hamsters. 28. Influence of isomerized squalene on gallstone production. | 1974 | Z Ernahrungswiss | pmid:4450595 |
Teshima S and Kanazawa A | Biosynthesis of sterols in abalone, Haliotis gurneri, and mussel, Mytilus edulis. | 1974 | Comp. Biochem. Physiol., B | pmid:4452229 |
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Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
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Frayha GJ | Synthesis of certain cholesterol precursors by hydatid protoscoleces of Echinococcus granulosus and cysticerci of Taenia hydatigena. | 1974 | Comp. Biochem. Physiol., B | pmid:4416028 |
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Beck FW and Whitehouse MW | I. Drug sensitivity of rat adjuvant arthritis, induced with "adjuvants" containing no mineral oil components. | 1974 | Proc. Soc. Exp. Biol. Med. | pmid:4841187 |
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Vidrine DW and Nicholas HJ | Squalene-2,3-epoxidase activity in rat brain during growth and maturation. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4842300 |
Lanyi JK | Irregular bilayer structure in vesicles prepared from Halobactbrium cutirubrum lipids. | 1974 | Biochim. Biophys. Acta | pmid:4846289 |
Lutsky BN et al. | In vitro incorporation of 14C-acetate into lipids of hamster flank organ (costovertebral organ) sebaceous glands and epidermis. | 1974 | Lipids | pmid:4810504 |
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Dennick RG and Dean PD | Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. | 1974 | J. Neurochem. | pmid:4277662 |
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Poulter CD | Model studies in terpene biosynthesis. | 1974 Mar-Apr | J. Agric. Food Chem. | pmid:4365118 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Radwan SS and Mangold HK | Lipids in plant tissue cultures. V. Effect of environmental conditions on the lipids of Glycine soja and Brassica napus cultures. | 1975 | Chem. Phys. Lipids | pmid:1168102 |
Teshima SI and Kanazawa A | Biosynthesis of sterols in a starfish, Laiaster leachii. | 1975 | Comp. Biochem. Physiol., B | pmid:1183195 |
Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
Jones JP et al. | Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. | 1975 | J. Neurochem. | pmid:1110355 |
Yamada Y et al. | Oxidative degradation of squalene by Arthrobacter species. | 1975 | Appl Microbiol | pmid:1115507 |
Safe S and Caldwell J | The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii. | 1975 | Can. J. Microbiol. | pmid:1116039 |
Voogt PA et al. | What about squalene in the earthworm Lumbricus terrestris? | 1975 | Comp. Biochem. Physiol., B | pmid:1122731 |
van Tamelen EE and Heys JR | Letter: Enzymic epoxidation of squalene variants. | 1975 | J. Am. Chem. Soc. | pmid:1133387 |
Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
Nestel PJ and Kudchodkar B | Plasma squalene as an index of cholesterol synthesis. | 1975 | Clin Sci Mol Med | pmid:1204294 |
Cunliffe WJ et al. | An explanation fro chloracne -- an industrial hazard. | 1975 | Acta Derm. Venereol. | pmid:50695 |
Tulliez J et al. | [The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism]. | 1975 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:807414 |
Scallen TJ et al. | Sterol carrier protein hypothesis: requirement for three substrate-specific soluble proteins in liver cholesterol biosynthesis. | 1975 | Life Sci. | pmid:165341 |
Ono T and Bloch K | Solubilization and partial characterization of rat liver squalene epoxidase. | 1975 | J. Biol. Chem. | pmid:234459 |
Strauss JS et al. | Skin lipids and acne. | 1975 | Annu. Rev. Med. | pmid:125065 |
Nurminen T et al. | Neutral lipids in the cells and cell envelope fractions of aerobic baker's yeast and anaerobic brewer's yeast. | 1975 | Chem. Phys. Lipids | pmid:1091369 |
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Grabowski GA et al. | Evidence for carrier proteins in bile acid synthesis. The effect of squalene and sterol carrier protein and albumin on the activity of 12alpha-hydroxylase. | 1976 | Biochim. Biophys. Acta | pmid:974090 |
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Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
Kushwaha SC and Kates M | Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. | 1976 | Can. J. Biochem. | pmid:1252986 |
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Beck FW and Whitehouse MW | Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. | 1976 | Agents Actions | pmid:822699 |
Trocha PJ and Sprinson DB | Location and regulation of early enzymes of sterol biosynthesis in yeast. | 1976 | Arch. Biochem. Biophys. | pmid:7207 |
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Kushwaha SC and Kates M | Lipid composition of Neurospora crassa. | 1976 | Lipids | pmid:136584 |
Cooper MF et al. | Sebaceous lipogenesis and androgen metabolism in acne. | 1976 | Biochem. Soc. Trans. | pmid:137154 |
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Kohashi O and Pearson CM | Arthritogenicity of Mycobacterium smegmatis subfractions, related to different oil vehicle and different composition. | 1976 | Int. Arch. Allergy Appl. Immunol. | pmid:1085757 |
Saat YA and Bloch KE | Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. | 1976 | J. Biol. Chem. | pmid:956181 |
Bell FP | Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate. | 1976 | Lipids | pmid:994746 |
Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |