(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

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Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Persian Gulf Syndrome D018923 1 associated lipids
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Fasciitis D005208 2 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Steatorrhea D045602 2 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Viremia D014766 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Fibrosarcoma D005354 8 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Fatigue D005221 10 associated lipids
Hepatitis D006505 11 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Influenza, Human D007251 11 associated lipids
Otitis Media D010033 12 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Keloid D007627 12 associated lipids
Rosacea D012393 13 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Olfaction Disorders D000857 17 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
Cholestasis D002779 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Fox CB et al. Immunomodulatory and physical effects of phospholipid composition in vaccine adjuvant emulsions. 2012 AAPS PharmSciTech pmid:22415641
Arias JL et al. Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. 2011 ACS Nano pmid:21275408
Maksimenko A et al. Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. 2014 ACS Nano pmid:24555414
Sémiramoth N et al. Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections. 2012 ACS Nano pmid:22482704
Jawaid AM et al. Shape-controlled colloidal synthesis of rock-salt lead selenide nanocrystals. 2011 ACS Nano pmid:21770427
Schubert K and Schumann W [On the biosynthesis of sterines]. 1967 Acta Biol. Med. Ger. pmid:5593407
Mullakhanbhai MF and Francis GW Bacterial lipids. 1. Lipid constituents of a moderately halophilic bacterium. 1972 Acta Chem Scand pmid:5049648
Liu CI et al. Structural insights into the catalytic mechanism of human squalene synthase. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531458
Cunliffe WJ et al. An explanation fro chloracne -- an industrial hazard. 1975 Acta Derm. Venereol. pmid:50695
Cotterill JA et al. Variation in skin surface lipid composition and sebum excretion rate with time. 1973 Acta Derm. Venereol. pmid:4127454
van Leusden HA et al. Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. 1971 Acta Endocrinol. pmid:5108099
Zadák Z et al. Polyunsaturated fatty acids, phytosterols and cholesterol metabolism in the Mediterranean diet. 2006 Acta Medica (Hradec Kralove) pmid:16696439
Arffmann E and Glavind J Studies by the newt test on carcinogenic properties of rats. 1967 Acta Pathol Microbiol Scand pmid:6050372
Ismail AA et al. Interrelation between thyroid hormones and essential fatty acids. 1966 Acta Physiol Acad Sci Hung pmid:5953398
Edgren B and Hellström K Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits. 1972 Acta Physiol. Scand. pmid:4640173
KROENING F [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. 1959 Acta Unio Int Contra Cancrum pmid:13848508
Caron J et al. Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene. 2013 Adv Healthc Mater pmid:23213041
Yasuda Y et al. Comparison of half and full doses of an MF59-adjuvanted cell culture-derived A/H1N1v vaccine in Japanese children. 2010 Adv Ther pmid:20586002
Haralampidis K et al. Biosynthesis of triterpenoid saponins in plants. 2002 Adv. Biochem. Eng. Biotechnol. pmid:11783842
Reddy LH and Couvreur P Squalene: A natural triterpene for use in disease management and therapy. 2009 Adv. Drug Deliv. Rev. pmid:19804806
Villee CA et al. The regulation of the biosynthesis of sterols and steroids in the placenta. 1966 Adv. Enzyme Regul. pmid:4862939
Kim SK and Karadeniz F Biological importance and applications of squalene and squalane. 2012 Adv. Food Nutr. Res. pmid:22361190
Beck FW and Whitehouse MW Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. 1976 Agents Actions pmid:822699
Pregliasco F et al. Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly. 2001 Aging (Milano) pmid:11292151
Kajaste-Rudnitski A et al. Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals. 2011 AIDS pmid:21150561
Durier C et al. Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults. 2013 AIDS pmid:23018437
Keefer MC et al. Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. 1996 AIDS Res. Hum. Retroviruses pmid:8744579
Ohkawa S et al. Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. 1994 AIDS Res. Hum. Retroviruses pmid:8179961
Vajdy M et al. Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. 2004 AIDS Res. Hum. Retroviruses pmid:15588349
Kelly GS Squalene and its potential clinical uses. 1999 Altern Med Rev pmid:9988781
Waterman E and Lockwood B Active components and clinical applications of olive oil. 2007 Altern Med Rev pmid:18069902
DICKHART W The squalene contents of various oils. 1955 Am J Pharm Sci Support Public Health pmid:13275573
Miettinen TA et al. Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism. 1987 Am. Heart J. pmid:3812207
Newmark HL Is oleic acid or squalene the important preventive agent? 2000 Am. J. Clin. Nutr. pmid:10919949
Downing DT et al. Changes in skin surface lipid composition induced by severe caloric restriction in man. 1972 Am. J. Clin. Nutr. pmid:5010536
Miettinen TA and Vanhanen H Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. 1994 Am. J. Clin. Nutr. pmid:8310985
Strauss JS et al. Surface lipid composition in children with protein-calorie malnutrition. 1978 Am. J. Clin. Nutr. pmid:414616
Villa M et al. Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. 2013 Am. J. Epidemiol. pmid:23863759
Mannino S et al. Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy. 2012 Am. J. Epidemiol. pmid:22940713
Skowronski DM et al. Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". 2013 Am. J. Epidemiol. pmid:23436898
Kanaji N et al. Positron emission tomography-positive squalene-induced lipoid pneumonia confirmed by gas chromatography-mass spectrometry of bronchoalveolar lavage fluid. 2008 Am. J. Med. Sci. pmid:18414072
Heikkinen T et al. Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. 2012 Am. J. Obstet. Gynecol. pmid:22939717
Carlson BC et al. The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats. 2000 Am. J. Pathol. pmid:10854227
Falcone DJ et al. Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. 1980 Am. J. Pathol. pmid:7361865
Hoffman SL et al. Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. 1994 Am. J. Trop. Med. Hyg. pmid:7985753
Bachman D et al. Effect of bacille Calmette-Guerin immunotherapy on feline sarcoma virus-induced neoplasms in the cat. 1982 Am. J. Vet. Res. pmid:6280529
Ruiz-Aragón J et al. [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature]. 2013 An Pediatr (Barc) pmid:23490433
Toh TH et al. Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry. 2001 Anal. Biochem. pmid:11141305
ROTHBLAT GH et al. A quantitative colorimetric assay for squalene. 1962 Anal. Biochem. pmid:14494417
Tait RM Development of a radiometric spot-wash assay for squalene synthase. 1992 Anal. Biochem. pmid:1416027