(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Persian Gulf Syndrome D018923 1 associated lipids
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Steatorrhea D045602 2 associated lipids
Fasciitis D005208 2 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Viremia D014766 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Fibrosarcoma D005354 8 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Fatigue D005221 10 associated lipids
Influenza, Human D007251 11 associated lipids
Hepatitis D006505 11 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Otitis Media D010033 12 associated lipids
Keloid D007627 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Periodontitis D010518 22 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Cholestasis D002779 23 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Blumer M Hydrocarbons in digestive tract and liver of a basking shark. 1967 Science pmid:5609822
Graebe JE Isoprenoid biosynthesis in a cell-free system from pea shoots. 1967 Science pmid:4381746
Hayaishi O and Nozaki M Nature and mechanisms of oxygenases. 1969 Science pmid:4304952
McLaren L et al. Dense-gas chromatography of nonvolatile substances of high molecular weight. 1968 Science pmid:5634909
Giddings JC et al. High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. 1968 Science pmid:5675186
De Souza NJ and Nes WR Sterols: isolation from a blue-green alga. 1968 Science pmid:5677529
Maugh TH Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. 1982 Science pmid:7146911
Del Giudice G et al. Seasonal influenza vaccine provides priming for A/H1N1 immunization. 2009 Sci Transl Med pmid:20371459
Khurana S et al. Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. 2010 Sci Transl Med pmid:20371470
Pollard AJ and Hill AV Antibody repertoire: embracing diversity. 2011 Sci Transl Med pmid:21795586
Khurana S et al. MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. 2011 Sci Transl Med pmid:21632986
Tsai TF et al. Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. 2011 Scand. J. Infect. Dis. pmid:21534891
Strandberg TE et al. Squalene and sterol synthesis in isolated small-intestinal cells of the rat. 1981 Scand. J. Gastroenterol. pmid:7323711
Tilvis RS et al. Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. 1978 Scand. J. Clin. Lab. Invest. pmid:628820
Koivisto PV and Miettinen TA Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. 1988 Scand. J. Clin. Lab. Invest. pmid:3217753
Miettinen TA and Tilvis R Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. 1981 Scand. J. Clin. Lab. Invest. pmid:7313530
Linares A et al. Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. 1984 Rev. Esp. Fisiol. pmid:6531508
VILLALBA GOMEZ GM [Squalene index]. 1956 May-Aug Rev Sanid Asist Soc pmid:13379961
Allison AC and Byars NE Syntex adjuvant formulation. 1992 Res. Immunol. pmid:1439132
Dillard CJ et al. Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. 1982 Res. Commun. Chem. Pathol. Pharmacol. pmid:7122999