(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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SHORB MS et al. | EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14277681 |
PATTERSON JF | Biosynthesis of squalene by rat preputial gland. | 1960 | Proc. Soc. Exp. Biol. Med. | pmid:13733368 |
Bazzano G and Bazzano GS | Hypocholesterolemic effect of -ketoglutarate in the Mongolian gerbil. | 1972 | Proc. Soc. Exp. Biol. Med. | pmid:5033114 |
FLESCH P | Hair loss from squalene. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14844354 |
Popják G et al. | Effects of 2,3-iminosqualene on cultured cells. | 1987 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:2894034 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379289 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379291 |
Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
Maksimenko A et al. | A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24385587 |
Vono M et al. | The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24324152 |
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Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
Mosca F et al. | Molecular and cellular signatures of human vaccine adjuvants. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18650390 |
Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Niehaus TD et al. | Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21746901 |
Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |