(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
Maksimenko A et al. | A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24385587 |
Vono M et al. | The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24324152 |
Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
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Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
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Volkov GL et al. | [In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. | 1976 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:1005362 |
Anisimov MM et al. | [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. | 1978 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:724665 |
Influenza vaccine with squalene adjuvant: new preparation. No better than available products. | 2004 | Prescrire Int | pmid:15599987 | |
Sliwowski J | [Mechanisms of squalene cyclization to tetra- and pentacyclic triterpenes (author's transl)]. | 1974 | Postepy Biochem. | pmid:4849151 |
Wojciechowski ZA | [Protein activators of the biosynthesis and metabolism of cholesterol]. | 1986 | Postepy Biochem. | pmid:3550764 |
JACHYMCZYK W | [Biosynthesis of triterpenoid compounds]. | 1963 | Postepy Biochem. | pmid:13957182 |
Henryk T et al. | [The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. | 2005 | Pol. Merkur. Lekarski | pmid:15997638 |
Lewkowicz N et al. | [Biological action and clinical application of shark liver oil]. | 2006 | Pol. Merkur. Lekarski | pmid:16875171 |
Gefenaite G et al. | Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. | 2013 | PLoS ONE | pmid:23840413 |
Wijnans L et al. | Effectiveness of MF59â„¢ adjuvanted influenza A(H1N1)pdm09 vaccine in risk groups in the Netherlands. | 2013 | PLoS ONE | pmid:23646191 |
Bischoff AL et al. | Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. | 2013 | PLoS ONE | pmid:23637733 |