(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |
Garbuzov AG et al. | Presence of squalene in human aorta. | 1966 May-Jun | Fed Proc Transl Suppl | pmid:5222095 |
Cherkes AI and Klebanov BM | [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. | 1966 Nov-Dec | Farmakol Toksikol | pmid:6000378 |
Johnson WS | Nonenzymic biogenetic-like olefinic cyclizations. | 1967 | Trans N Y Acad Sci | pmid:5237390 |
Willett JD et al. | Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. | 1967 | J. Biol. Chem. | pmid:6061706 |
van Tamelen EE et al. | Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6064361 |
Corey EJ and Gross SK | Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6046552 |
Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
Katsuki H and Bloch K | Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. | 1967 | J. Biol. Chem. | pmid:6016607 |
Kellum RE | Human sebaceous gland lipids. Analysis by thin-layer chromatography. | 1967 | Arch Dermatol | pmid:6019001 |