(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Fasciitis D005208 2 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Steatorrhea D045602 2 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Viremia D014766 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Fibrosarcoma D005354 8 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Fatigue D005221 10 associated lipids
Hepatitis D006505 11 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Influenza, Human D007251 11 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Keloid D007627 12 associated lipids
Otitis Media D010033 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
Cholestasis D002779 23 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Douglas TJ et al. Inhibition of cholesterol biosynthesis in ovine ovarian follicles in vitro by human chorionic gonadotrophin. 1978 Aust. J. Biol. Sci. pmid:571711
Mukherjee S and Bhose A Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. 1968 Biochim. Biophys. Acta pmid:5721032
Threlfall DR et al. Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. 1968 Biochem. J. pmid:5721452
Autrum H et al. [Squalene in the glandular secretion of mammals]. 1968 Naturwissenschaften pmid:5726004
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091
Porcellati G and Giorgini D The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. 1969 Biochem. Pharmacol. pmid:5772592
Goad LJ and Goodwin TW Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. 1969 Eur. J. Biochem. pmid:5780485
Eppenberger U et al. [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. 1969 Eur. J. Biochem. pmid:5781271
Ikekawa N et al. Determination of morphine in urine by gas chromatography. 1969 Anal. Biochem. pmid:5781407
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
Tornabene TG et al. Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. 1969 J. Lipid Res. pmid:5785002
Porcellati G et al. Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. 1969 Lipids pmid:5785689
Boyd GS and Onajobi FD Control of cholesterol biosynthesis by a plasma apo-lipoprotein. 1969 Nature pmid:5789314
Witiak DT et al. Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. 1969 J. Med. Chem. pmid:5793168
Rees HH et al. 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. 1969 Biochim. Biophys. Acta pmid:5797101
Walton TJ et al. Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. 1969 Biochem. J. pmid:5801311
Miettinen TA Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. 1969 Life Sci. pmid:5801489
Foti L et al. Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. 1969 Life Sci. pmid:5804653
Yamamoto S and Bloch K On the enzymes catalysing the transformation of squalene to lanosterol. 1969 Biochem. J. pmid:5807185
Higgins MJ and Kekwick RG The role of malonyl-coenzyme A in isoprenoid biosynthesis. 1969 Biochem. J. pmid:5807201
Malathi P and Ganguly J Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. 1964 Biochem. J. pmid:5837438
Van Leusden H and Villee CA The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. 1965 Steroids pmid:5857495
Kipping D [Observations on skin surface fats]. 1965 Z Haut Geschlechtskr pmid:5860995
Paroli E [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. 1964 Boll. Soc. Ital. Biol. Sper. pmid:5877121
Garbuzov AG et al. [The presence of squalene in the human aorta]. 1965 Arkh. Patol. pmid:5881137
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648
Cory EJ et al. 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. 1966 J. Am. Chem. Soc. pmid:5918046
Corey EJ and Russey WE Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. 1966 J. Am. Chem. Soc. pmid:5918047
Van Tamelen EE et al. Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. 1966 J. Am. Chem. Soc. pmid:5918048
Cmelik SH and Webster GD Squalene in vernix caseosa from African neonates. 1966 Cent Afr J Med pmid:5919884
Hsia SL et al. Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. 1966 J. Invest. Dermatol. pmid:5924299
Butterworth PH et al. In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. 1966 Arch. Biochem. Biophys. pmid:5944963
Ismail AA et al. Interrelation between thyroid hormones and essential fatty acids. 1966 Acta Physiol Acad Sci Hung pmid:5953398
Zelewski L and Villee CA The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta. 1966 Biochemistry pmid:5963423
Paoletti P et al. Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. 1966 Neurochirurgia (Stuttg) pmid:5966653
Williams RJ et al. A possible mechanism for the biosynthesis of eschscholtzxanthin. 1966 Biochim. Biophys. Acta pmid:5966716
Chesterton CJ The subcellular site of cholesterol synthesis in rat liver. 1966 Biochem. Biophys. Res. Commun. pmid:5971766
Brooks CJ et al. Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. 1966 Biochim. Biophys. Acta pmid:5973204
Van Tamelen EE et al. Nonenzymic laboratory cyclization of squalene 2,3-oxide. 1966 J. Am. Chem. Soc. pmid:5980879
Wiss O and Wiss V The influence of fasting on the synthesis of cholesterol, squalene, fatty acids, and ubiquinones in liver, small intestine, and kidney of rats in vivo. 1977 Helv. Chim. Acta pmid:599042
Wiss O and Wiss V On the influence of cholesterol feeding and of a lipogenic diet on the cholesterogenesis in rat liver in vivo. 1977 Helv. Chim. Acta pmid:599043
Cherkes AI and Klebanov BM [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. 1966 Nov-Dec Farmakol Toksikol pmid:6000378
Hellig HR and Savard K Sterol biosynthesis in the bovine corpus luteum in vitro. 1966 Biochemistry pmid:6006805
Katsuki H and Bloch K Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. 1967 J. Biol. Chem. pmid:6016607
Kellum RE Human sebaceous gland lipids. Analysis by thin-layer chromatography. 1967 Arch Dermatol pmid:6019001
Matschiner JT et al. Effect of indigestible oils on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021812
Matschiner JT et al. Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021953
Kellum RE Short chain fatty acids (below C12) of human skin surface lipids. 1967 J. Invest. Dermatol. pmid:6022603
Dean PD et al. A soluble 2,3-oxidosqualene sterol cyclase. 1967 J. Biol. Chem. pmid:6027261
Rao KS and Olson RE The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. 1967 Biochem. Biophys. Res. Commun. pmid:6030977
Corey EJ and Ortiz de Montellano PR Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. 1967 J. Am. Chem. Soc. pmid:6042774
van Tamelen EE et al. On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. 1967 J. Am. Chem. Soc. pmid:6042776
Corey EJ et al. 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. 1967 J. Am. Chem. Soc. pmid:6043808
Young TE and Maggs RJ The use of a moving wire detector system for the study of liquid chromatographic columns. 1967 May-Jun Anal. Chim. Acta pmid:6045413
Corey EJ and Gross SK Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. 1967 J. Am. Chem. Soc. pmid:6046552
Rao KS and Olson RE The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. 1967 Biochim. Biophys. Acta pmid:6049507
Arffmann E and Glavind J Studies by the newt test on carcinogenic properties of rats. 1967 Acta Pathol Microbiol Scand pmid:6050372
Willett JD et al. Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. 1967 J. Biol. Chem. pmid:6061706
van Tamelen EE et al. Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. 1967 J. Am. Chem. Soc. pmid:6064361
Grob EC and Csupor L [Information on the leaf lipids of Acer platanoides L. during autumn yellowing]. 1967 Experientia pmid:6077859
Cain CE et al. Hydrocarbons from human meninges and meningiomas. 1967 Biochim. Biophys. Acta pmid:6078120
Eilenberg H and Shechter I A possible regulatory role of squalene epoxidase in Chinese hamster ovary cells. 1984 Lipids pmid:6087072
Cenedella RJ Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. 1980 Biochem. Pharmacol. pmid:6159896
Cicchini T et al. [The importance of man, mouse and rat skin surface lipid fractions on the "in vitro" penetration of "Schistosoma mansoni" cercariae (author's transl)]. 1977 Sep-Oct Ann Sclavo pmid:616258
Cherayil GD et al. Abnormal lipid composition of fat tissue in human mesenteric panniculitis. 1981 Lipids pmid:6163941
Ohkido M et al. Lipid peroxide of human skin. 1980 Curr. Probl. Dermatol. pmid:6165521
Lay JP et al. Metabolism of beta-hexachlorocyclohexane-14C in rats following low dosing in the daily diet. 1981 J Environ Sci Health B pmid:6166652
Richter E et al. Excretion of beta-hexachlorocyclohexane by the rat as influenced by oral paraffin, squalane, and Lutrol E 400. 1981 Ecotoxicol. Environ. Saf. pmid:6170505
Matsuo I et al. Mechanism of skin surface lipid peroxidation. 1983 Curr. Probl. Dermatol. pmid:6197240
Stewart ME et al. Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. 1984 J. Invest. Dermatol. pmid:6228612
Bachman D et al. Effect of bacille Calmette-Guerin immunotherapy on feline sarcoma virus-induced neoplasms in the cat. 1982 Am. J. Vet. Res. pmid:6280529
Tilvis RS et al. Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. 1978 Scand. J. Clin. Lab. Invest. pmid:628820
Pinto WJ and Nes WR Stereochemical specificity for sterols in Saccharomyces cerevisiae. 1983 J. Biol. Chem. pmid:6339498
Pinto WJ et al. Stereochemically distinct roles for sterol in Saccharomyces cerevisiae. 1983 Biochem. Biophys. Res. Commun. pmid:6340686
Jahnke L and Klein HP Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae. 1983 J. Bacteriol. pmid:6348021
Ryder NS et al. Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. 1984 Antimicrob. Agents Chemother. pmid:6375557
Wood SG and Gottlieb D Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637849
Wood SG and Gottlieb D Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. 1978 Biochem. J. pmid:637850
Wielgosz GJ and Armstrong DT Effects of prolactin, progesterone, and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat. 1978 Can. J. Physiol. Pharmacol. pmid:638868
Takeuchi N et al. Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. 1978 Exp. Gerontol. pmid:639893
Richter E et al. Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane. 1983 Xenobiotica pmid:6415933
Scott MT et al. Adjuvant requirements for protective immunization of mice using a Trypanosoma cruzi 90K cell surface glycoprotein. 1984 Int. Arch. Allergy Appl. Immunol. pmid:6429057
Chen HW and Leonard DA Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. 1984 J. Biol. Chem. pmid:6429139
Strauss JS et al. The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. 1980 J. Invest. Dermatol. pmid:6444323
Bhavnani BR Oestrogen biosynthesis in the pregnant mare. 1981 J. Endocrinol. pmid:6453917
Miettinen TA Cholesterol and bile acid synthesis in two families with homozygous and heterozygous hypercholesterolemia. 1984 Jul-Aug Arteriosclerosis pmid:6466195
Arce V et al. The in vivo incorporation of acetate into different non-saponifiable lipids by neonatal chick tissues. 1984 Comp. Biochem. Physiol., B pmid:6478791
Chin J and Bloch K Role of supernatant protein factor and anionic phospholipid in squalene uptake and conversion by microsomes. 1984 J. Biol. Chem. pmid:6480582
Ohsawa K et al. The possible role of squalene and its peroxide of the sebum in the occurrence of sunburn and protection from the damage caused by U.V. irradiation. 1984 J Toxicol Sci pmid:6481825
Schroeder F et al. Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. 1984 Biochem. Biophys. Res. Commun. pmid:6497882
Peyronel D et al. Fatty acid and squalene compositions of Mediterranean Centrophorus SPP egg and liver oils in relation to age. 1984 Lipids pmid:6503627
Linares A et al. Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. 1984 Rev. Esp. Fisiol. pmid:6531508
Kajiyama G et al. Serum squalene in patients with gallstones. 1983 Hiroshima J. Med. Sci. pmid:6618897
Strandberg TE Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo. 1983 Lipids pmid:6621260
Bell FP and Hubert EV Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. 1983 Lipids pmid:6633175
Rahier A et al. Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. 1983 Biochem. Soc. Trans. pmid:6642064
Aguilera JA et al. Incorporation of mevalonate into squalene, lanosterol and cholesterol by different neonatal chick tissues. 1983 Int. J. Biochem. pmid:6653866
Zaaijer D and van der Horst CJ Cyclic changes in hormones, carbohydrates and indole metabolism in cervical mucus of normal, fertilizing cows and the relationship with non-fertility. 1983 Cytobios pmid:6684538
Dykes PJ et al. Analysis of the non-ionic detergent-soluble lipids of human stratum corneum. 1984 Br. J. Dermatol. pmid:6696844
Yachnin S and Mannickarottu V Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. 1984 Blood pmid:6696995