(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
RABINOWITZ JL et al. | Branched chain acids in the biosynthesis of squalene and cholesterol. | 1955 | Fed. Proc. | pmid:13262139 |
CORNFORTH JW and POPJAK G | Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. | 1954 | Biochem. J. | pmid:13208629 |
SQUALENE, a precursor of cholesterol. | 1954 | Nutr. Rev. | pmid:13166142 | |
EIDINOFF ML et al. | The biosynthesis of squalene from acetate in man. | 1954 | J. Clin. Invest. | pmid:13143078 |
POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
WHEATLEY VR | Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. | 1953 | Biochem. J. | pmid:13115346 |
LANGDON RG and BLOCH K | The biosynthesis of squalene. | 1953 | J. Biol. Chem. | pmid:13034767 |
LANGDON RG and BLOCH K | The utilization of squalene in the biosynthesis of cholesterol. | 1953 | J. Biol. Chem. | pmid:13034768 |