(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chida N and Okamura T | Increased cholesterol-biosynthesis in familial hypercholesterolemia. | 1971 | Tohoku J. Exp. Med. | pmid:5140375 |
| Torinuki W et al. | Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. | 1982 | Tohoku J. Exp. Med. | pmid:7101278 |
| Ali HM et al. | Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. | 2014 | Thyroid | pmid:23885719 |
| Miettinen TA | Hyperlipoproteinemia--relation to platelet lipids, platelet function and tendency to thrombosis. | 1974 | Thromb. Res. | pmid:4367389 |
| Alghisi F et al. | Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis. | 2011 | Thorax | pmid:21228426 |
| Achiraman S et al. | Increased squalene concentrations in the clitoral gland during the estrous cycle in rats: an estrus-indicating scent mark? | 2011 | Theriogenology | pmid:21924481 |
| Montana M et al. | Safety review: squalene and thimerosal in vaccines. | 2010 Nov-Dec | Therapie | pmid:21176760 |
| Dorea JG | Safety of thimerosal in vaccines: for whom and how many doses? | 2011 Mar-Apr | Therapie | pmid:23189333 |
| Corey EJ and Yamamoto H | Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. | 1970 | Tetrahedron Lett. | pmid:5447652 |
| Rees HH et al. | Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. | 1968 | Tetrahedron Lett. | pmid:5640097 |
| Abe I | [Bioorganic chemistry of squalene cyclase]. | 1994 | Tanpakushitsu Kakusan Koso | pmid:8090933 |
| Yamamoto S | [Oxidative cyclization of squalene. Biosynthesis of sterols]. | 1970 | Tanpakushitsu Kakusan Koso | pmid:4912088 |
| Dennick RG | The intracellular organisation of cholesterol biosynthesis. A review. | 1972 | Steroids Lipids Res | pmid:4572325 |
| Van Leusden H and Villee CA | The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. | 1965 | Steroids | pmid:5857495 |
| Cattel L et al. | Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase. | 1989 Mar-May | Steroids | pmid:2678608 |
| Nitchuk WM and Ainsworth L | The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. | 1972 | Steroids | pmid:5028884 |
| Seo S et al. | Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. | 1993 | Steroids | pmid:8484187 |
| Giera M et al. | Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway. | 2007 | Steroids | pmid:17583759 |
| Lewis D et al. | Enzyme inhibition during the conversion of squalene to cholesterol. | 1995 | Steroids | pmid:7482633 |
| Dean PD | The cyclases of triterpene and sterol biosynthesis. | 1971 | Steroidologia | pmid:5004310 |
| Couvreur P et al. | Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. | 2008 | Small | pmid:18247384 |
| Chiba K et al. | Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784064 |
| Zouboulis CC et al. | Culture of human sebocytes and markers of sebocytic differentiation in vitro. | 1991 | Skin Pharmacol. | pmid:1715175 |
| Wohlrab J et al. | Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine. | 2010 | Skin Pharmacol Physiol | pmid:20523109 |
| Ekanayake-Mudiyanselage S et al. | Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids. | 2005 Jan-Feb | Skin Pharmacol Physiol | pmid:15608499 |
| Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
| Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
| Blumer M | Hydrocarbons in digestive tract and liver of a basking shark. | 1967 | Science | pmid:5609822 |
| Wendt KU et al. | Structure and function of a squalene cyclase. | 1997 | Science | pmid:9295270 |
| Graebe JE | Isoprenoid biosynthesis in a cell-free system from pea shoots. | 1967 | Science | pmid:4381746 |
| Crispino GA et al. | Selective perhydroxylation of squalene: taming the arithmetic demon. | 1993 | Science | pmid:8418495 |
| Hayaishi O and Nozaki M | Nature and mechanisms of oxygenases. | 1969 | Science | pmid:4304952 |
| McLaren L et al. | Dense-gas chromatography of nonvolatile substances of high molecular weight. | 1968 | Science | pmid:5634909 |
| Giddings JC et al. | High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. | 1968 | Science | pmid:5675186 |
| De Souza NJ and Nes WR | Sterols: isolation from a blue-green alga. | 1968 | Science | pmid:5677529 |
| Maugh TH | Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. | 1982 | Science | pmid:7146911 |
| Sherman DR et al. | Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. | 1992 | Science | pmid:1470914 |
| Del Giudice G et al. | Seasonal influenza vaccine provides priming for A/H1N1 immunization. | 2009 | Sci Transl Med | pmid:20371459 |
| Khurana S et al. | Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. | 2010 | Sci Transl Med | pmid:20371470 |
| Pollard AJ and Hill AV | Antibody repertoire: embracing diversity. | 2011 | Sci Transl Med | pmid:21795586 |
| Khurana S et al. | MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. | 2011 | Sci Transl Med | pmid:21632986 |
| Tsai TF et al. | Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. | 2011 | Scand. J. Infect. Dis. | pmid:21534891 |
| Strandberg TE et al. | Squalene and sterol synthesis in isolated small-intestinal cells of the rat. | 1981 | Scand. J. Gastroenterol. | pmid:7323711 |
| Tilvis RS et al. | Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. | 1978 | Scand. J. Clin. Lab. Invest. | pmid:628820 |
| Koivisto PV and Miettinen TA | Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. | 1988 | Scand. J. Clin. Lab. Invest. | pmid:3217753 |
| Miettinen TA and Tilvis R | Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. | 1981 | Scand. J. Clin. Lab. Invest. | pmid:7313530 |
| Linares A et al. | Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. | 1984 | Rev. Esp. Fisiol. | pmid:6531508 |
| VILLALBA GOMEZ GM | [Squalene index]. | 1956 May-Aug | Rev Sanid Asist Soc | pmid:13379961 |
| Allison AC and Byars NE | Syntex adjuvant formulation. | 1992 | Res. Immunol. | pmid:1439132 |
| Dillard CJ et al. | Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. | 1982 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7122999 |