(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lopez D et al. | Compensatory responses to inhibition of hepatic squalene synthase. | 1998 | Arch. Biochem. Biophys. | pmid:9514656 |
BEELER DA et al. | The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. | 1963 | Arch. Biochem. Biophys. | pmid:13970235 |
Okada S et al. | Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. | 2004 | Arch. Biochem. Biophys. | pmid:14725863 |
POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
Fujita H et al. | Chlorpromazine-sensitized photooxidation of squalene. | 1986 | Arch. Dermatol. Res. | pmid:3729541 |
Fujie T et al. | Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. | 1996 | Arch. Dermatol. Res. | pmid:8931874 |
Yamamoto A et al. | Impaired water barrier function in acne vulgaris. | 1995 | Arch. Dermatol. Res. | pmid:7763094 |
Aguilera JA et al. | Age-related changes in the mevalonate metabolism in vivo in chick kidneys. | 1988 | Arch. Int. Physiol. Biochim. | pmid:2460056 |
GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
SEDEE PD | Intermediary metabolism in aseptically reared blowfly larvae, Calliphora erythrocephala (Meig.). I. Buosynthesis of squalene and cholesterol. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13749584 |
GOSSELIN L | Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. | 1962 | Arch. Int. Physiol. Biochim. | pmid:13900655 |
Gosselin L | [Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides]. | 1964 | Arch. Int. Physiol. Biochim. | pmid:4157959 |
Gosselin L and Duvivier J | [On the utilization of C14-2-mevalonic acid by cell fractions of bovine adrenal gland homogenates]. | 1965 | Arch. Int. Physiol. Biochim. | pmid:4158100 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in mollusca. X. Biosynthesis and composition of 3 beta-sterols in Cephalopoda. | 1973 | Arch. Int. Physiol. Biochim. | pmid:4127479 |
Saxena SC and Zandee DI | Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. | 1969 | Arch. Int. Physiol. Biochim. | pmid:4188405 |
Voogt PA and Van der Horst DJ | Investigations of the capacity of synthesizing 3 -sterols in mollusca. 8. The biosynthesis of 3 -sterols in the pulmonates "Succinea putris" and "Arianta arbustorum". | 1972 | Arch. Int. Physiol. Biochim. | pmid:4114875 |
Voogt PA | Biosynthesis of 3-beta-sterols in a snail, Arion rufus L., from 1-14C-acetate. | 1967 | Arch. Int. Physiol. Biochim. | pmid:4167714 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. | 1968 | Arch. Int. Physiol. Biochim. | pmid:4178041 |