(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yamada Y et al. | Oxidation of acyclic terpenoids by Corynebacterium sp. | 1985 | Appl. Environ. Microbiol. | pmid:4004225 |
Yamada Y et al. | Oxidation of linear terpenes and squalene variants by Arthrobacter sp. | 1977 | Appl. Environ. Microbiol. | pmid:869527 |
Donald KA et al. | Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. | 1997 | Appl. Environ. Microbiol. | pmid:9292983 |
Berekaa MM and Steinbüchel A | Microbial degradation of the multiply branched alkane 2,6,10,15,19, 23-hexamethyltetracosane (Squalane) by Mycobacterium fortuitum and Mycobacterium ratisbonense. | 2000 | Appl. Environ. Microbiol. | pmid:11010899 |
Siedenburg G and Jendrossek D | Squalene-hopene cyclases. | 2011 | Appl. Environ. Microbiol. | pmid:21531832 |
Tokuhiro K et al. | Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae. | 2009 | Appl. Environ. Microbiol. | pmid:19592534 |
Kamimura N et al. | Construction of squalene-accumulating Saccharomyces cerevisiae mutants by gene disruption through homologous recombination. | 1994 | Appl. Microbiol. Biotechnol. | pmid:7765777 |
Chang MH et al. | The isolation and characterization of Pseudozyma sp. JCC 207, a novel producer of squalene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18299826 |
Short RV | The synthesis and secretion of steroids by the corpus luteum. | 1967 | Arch Anat Microsc Morphol Exp | pmid:4973334 |
Kligman AM et al. | Comedogenicity of human sebum. | 1970 | Arch Dermatol | pmid:4247928 |