(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borchman D et al. | Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. | 2013 | Lipids | pmid:24081494 |
| Bell FP and Hubert EV | Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. | 1983 | Lipids | pmid:6633175 |
| Yeo HC and Shibamoto T | Formation of formaldehyde and malonaldehyde by photooxidation of squalene. | 1992 | Lipids | pmid:1608304 |
| Choo YM et al. | Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil. | 2005 | Lipids | pmid:16028723 |
| Cherayil GD et al. | Abnormal lipid composition of fat tissue in human mesenteric panniculitis. | 1981 | Lipids | pmid:6163941 |
| Eilenberg H and Shechter I | A possible regulatory role of squalene epoxidase in Chinese hamster ovary cells. | 1984 | Lipids | pmid:6087072 |
| Scallen TJ et al. | Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder. | 1971 | Lipids | pmid:4396848 |
| Shah SN | Regulation of hepatic cholesterol synthesis from mevalonate in suckling and weaned rats. | 1973 | Lipids | pmid:4713377 |
| Matthan NR et al. | Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women. | 2000 | Lipids | pmid:11026626 |
| Nes WR | Regulation of the sequencing in sterol biosynthesis. | 1971 | Lipids | pmid:4997338 |
| Cattel L et al. | The squalene-2,3-epoxide cyclase as a model for the development of new drugs. | 1986 | Lipids | pmid:3515096 |
| Lees ND et al. | Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. | 1995 | Lipids | pmid:7791529 |
| Abe I and Prestwich GD | Identification of the active site of vertebrate oxidosqualene cyclase. | 1995 | Lipids | pmid:7791531 |
| Cattel L et al. | 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. | 1995 | Lipids | pmid:7791532 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Lutsky BN et al. | In vitro incorporation of 14C-acetate into lipids of hamster flank organ (costovertebral organ) sebaceous glands and epidermis. | 1974 | Lipids | pmid:4810504 |
| Tilvis RS and Miettinen TA | Absorption and metabolic fate of dietary 3H-squalene in the rat. | 1983 | Lipids | pmid:6855483 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods. | 1971 | Lipids | pmid:5559874 |
| Van Sickle WA et al. | Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. | 1992 | Lipids | pmid:1326069 |
| Morin RJ et al. | Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities. | 1982 | Lipids | pmid:7121212 |
| Lewis RW | Effect of alimentation on human serum squalene levels. | 1976 | Lipids | pmid:180373 |
| Lindholm JS and Downing DT | Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. | 1980 | Lipids | pmid:7219074 |
| Bell FP and Hubert EV | Stimulation of hepatic squalene and triglyceride synthesis by dimethylsulfoxide, in vitro. | 1982 | Lipids | pmid:7162368 |
| Srikantaiah MV et al. | Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins. | 1980 | Lipids | pmid:7432102 |
| Iannitti T and Palmieri B | An update on the therapeutic role of alkylglycerols. | 2010 | Mar Drugs | pmid:20948908 |
| Hernández-GarcÃa I et al. | [Adverse events after administration of A/H1N1 vaccine to patients]. | 2011 | Med Clin (Barc) | pmid:20199781 |
| Saadatzadeh MR et al. | Production of the mycelial phase of Malassezia in vitro. | 2001 | Med. Mycol. | pmid:11798054 |
| De Luca C and Valacchi G | Surface lipids as multifunctional mediators of skin responses to environmental stimuli. | 2010 | Mediators Inflamm. | pmid:20981292 |
| Cuzzopoli M et al. | Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. | 1972 | Metab. Clin. Exp. | pmid:4641957 |
| Gylling H et al. | Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. | 1991 | Metab. Clin. Exp. | pmid:1984567 |
| Relas H et al. | Effect of stanol ester on postabsorptive squalene and retinyl palmitate. | 2000 | Metab. Clin. Exp. | pmid:10778871 |
| Salvioli G et al. | Relationships between squalene and cholesterol in bile: effect of ursodeoxycholic acid administration in patients with radiolucent gallstones. | 1984 | Metab. Clin. Exp. | pmid:6738365 |
| Nakano M et al. | 3-(4'-methyl-1'-naphthyl)propionic acid, 1',4'-endoperoxide for dioxygenation of squalene and for bacterial killing. | 2000 | Meth. Enzymol. | pmid:10907513 |
| Maes D et al. | Noninvasive techniques for measuring oxidation products on the surface of human skin. | 2000 | Meth. Enzymol. | pmid:10907548 |
| Nishino T and Katsuki H | Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase. | 1985 | Meth. Enzymol. | pmid:3894880 |
| Allison AC | Squalene and squalane emulsions as adjuvants. | 1999 | Methods | pmid:10525443 |
| Colombatti M and Dosio F | Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immunotoxins. | 2001 | Methods Mol. Biol. | pmid:11217376 |
| Huang MH et al. | Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine. | 2009 May-Jun | Microbes Infect. | pmid:19344782 |
| Perzl M et al. | Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. | 1997 | Microbiology (Reading, Engl.) | pmid:9141686 |
| Kerwin JL et al. | Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. | 1995 | Microbiology (Reading, Engl.) | pmid:7704271 |
| HADORN H and JUNGKUNZ R | [Further studies on squalene. 4]. | 1950 | Mitt Lebensmittelunters Hyg | pmid:14806249 |
| O'Hagan DT et al. | Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. | 1997 | Mol Med Today | pmid:9060004 |
| Granados-Principal S et al. | Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. | 2012 | Mol Nutr Food Res | pmid:22648620 |
| Vriet C et al. | From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom. | 2013 | Mol Plant | pmid:23761349 |
| Lamb DC et al. | Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. | 2007 | Mol. Biol. Evol. | pmid:17567593 |
| Popják G and Agnew WS | Squalene synthetase. | 1979 | Mol. Cell. Biochem. | pmid:41173 |
| GarcÃa-Román N et al. | Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. | 2001 | Mol. Cell. Neurosci. | pmid:11178870 |
| Karst F and Lacroute F | Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. | 1977 | Mol. Gen. Genet. | pmid:200835 |
| Allison AC and Byars NE | Immunological adjuvants: desirable properties and side-effects. | 1991 | Mol. Immunol. | pmid:1850114 |
| Reddy LH et al. | Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor. | 2009 Sep-Oct | Mol. Pharm. | pmid:19634915 |