(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shenoy SD et al. | Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | 2004 | Mol. Pharmacol. | pmid:15102959 |
Huang ZR et al. | Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. | 2009 | Molecules | pmid:19169201 |
Fox CB | Squalene emulsions for parenteral vaccine and drug delivery. | 2009 | Molecules | pmid:19783926 |
Lokvam J and Fine PV | An oxidized squalene derivative from Protium subserratum Engl. (Engl.) growing in Peru. | 2012 | Molecules | pmid:22706374 |
Piccialli V et al. | Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuOâ‚„ and its double ring expansion to a novel bis-THF-bis-THP compound. | 2011 | Molecules | pmid:21709619 |
AÄimoviÄ J and Rozman D | Steroidal triterpenes of cholesterol synthesis. | 2013 | Molecules | pmid:23558541 |
Fan SR et al. | Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. | 1996 | Mutat. Res. | pmid:8692222 |
Hamdan JS and Casali AK | Effect of amphotericin B on the lipids of yeast cells of Sporothrix schenckii. | 1996-1997 | Mycopathologia | pmid:9276941 |
Campagnac E et al. | Fenpropimorph slows down the sterol pathway and the development of the arbuscular mycorrhizal fungus Glomus intraradices. | 2009 | Mycorrhiza | pmid:19340463 |
Voyron S et al. | Antifungal activity of bis-azasqualenes, inhibitors of oxidosqualene cyclase. | 2010 | Mycoses | pmid:19549106 |
Airaudi D et al. | In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. | 1996 Jan-Feb | Mycoses | pmid:8786759 |
Airaudi D et al. | Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. | 1995 Jul-Aug | Mycoses | pmid:8559196 |
Chen G et al. | Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. | 2010 | N Biotechnol | pmid:20412873 |
Stephenson I et al. | Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. | 2008 | N. Engl. J. Med. | pmid:18843132 |
Pass RF et al. | Vaccine prevention of maternal cytomegalovirus infection. | 2009 | N. Engl. J. Med. | pmid:19297572 |
Clark TW et al. | Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine. | 2009 | N. Engl. J. Med. | pmid:19745215 |
Vesikari T et al. | Oil-in-water emulsion adjuvant with influenza vaccine in young children. | 2011 | N. Engl. J. Med. | pmid:21995388 |
Ambrose CS and Belshe RB | Influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22276839 |
Heikkinen T and Heinonen S | Influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22276840 |
Sancho A et al. | More on influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22738111 |
Miettinen TA et al. | Serum squalene and methyl sterols. | 1970 | N. Engl. J. Med. | pmid:5470273 |
Gallin JI et al. | Increased serum levels of seualene in patients with acute influenza. | 1970 | N. Engl. J. Med. | pmid:5442630 |
Villee CA | Shark oil and medicine. | 1970 | N. Engl. J. Med. | pmid:5462581 |
Finotti E et al. | Synergistic effects of alpha-tocopherol, beta-sitosterol and squalene on antioxidant activity assayed by crocin bleaching method. | 2000 | Nahrung | pmid:11075383 |
Couvreur P et al. | Squalenoyl nanomedicines as potential therapeutics. | 2006 | Nano Lett. | pmid:17090088 |
Réjiba S et al. | Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. | 2011 | Nanomedicine | pmid:21419876 |
Pili B et al. | Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. | 2010 | Nanoscale | pmid:20820745 |
Zhang XH et al. | Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods. | 2012 | Nat Prod Commun | pmid:22428257 |
Harrison DM | The biosynthesis of triterpenoids and steroids. | 1985 | Nat Prod Rep | pmid:3913885 |
Abe I et al. | Inhibitors of squalene biosynthesis and metabolism. | 1994 | Nat Prod Rep | pmid:15200015 |
Connolly JD and Hill RA | Triterpenoids. | 2002 | Nat Prod Rep | pmid:12195814 |
Ali NA et al. | Essential oil composition of leaves of Stachys yemenensis obtained by supercritical COâ‚‚. | 2010 | Nat. Prod. Res. | pmid:21104527 |
Naughton C et al. | Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. | 2013 | Nat. Struct. Mol. Biol. | pmid:23416946 |
Wadman M | Race is on for flu vaccine. | 2005 | Nature | pmid:16267526 |
Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
Clark RP and Shirley SG | Identification of skin in airborne particulate matter. | 1973 | Nature | pmid:4585846 |
LUCY JA and DINGLE JT | FAT-SOLUBLE VITAMINS AND BIOLOGICAL MEMBRANES. | 1964 | Nature | pmid:14222261 |
WOOTTON JM and WRIGHT LD | Biosynthesis of squalene by the annelid Lumbricus terrestris. | 1960 | Nature | pmid:13786660 |
ALAM SQ et al. | Detection and estimation of squalene in leaves. | 1962 | Nature | pmid:13860005 |
Bird CW et al. | Steroids and squalene in Methylococcus capsulatus grown on methane. | 1971 | Nature | pmid:4929985 |
GOSSELIN L et al. | Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. | 1962 | Nature | pmid:13900654 |
Phytochemistry: terpenoids for progress. | 1970 | Nature | pmid:5437511 | |
Lewis RW | Distribution of dietary squalene in a wandering Albatross, diomedea exultans. | 1969 | Nature | pmid:5358352 |
Boyd GS and Onajobi FD | Control of cholesterol biosynthesis by a plasma apo-lipoprotein. | 1969 | Nature | pmid:5789314 |
Brassell SC et al. | Specific acyclic isoprenoids as biological markers of methanogenic bacteria in marine sediments. | 1981 | Nature | pmid:7219553 |
HELLER JH et al. | Squalene content of various shark livers. | 1957 | Nature | pmid:13430738 |
Ackman RG et al. | Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. | 1968 | Nature | pmid:5701840 |
Autrum H et al. | [Squalene in the glandular secretion of mammals]. | 1968 | Naturwissenschaften | pmid:5726004 |
Das B et al. | Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. | 2008 | Neoplasia | pmid:18813359 |
Esposito S et al. | An open-label, randomized clinical trial assessing immunogenicity, safety and tolerability of pandemic influenza A/H1N1 MF59-adjuvanted vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to paediatric kidney transplant recipients. | 2011 | Nephrol. Dial. Transplant. | pmid:20974645 |