(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wiss O and Wiss V | On metabolic degradations of squalene, lanosterol and cholesterol in rat liver in vivo. Evidence for recycling of metabolites for the synthesis of isoprene compounds. | 1977 | Helv. Chim. Acta | pmid:914630 |
Perzl M et al. | Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. | 1997 | Microbiology (Reading, Engl.) | pmid:9141686 |
Kawakami T et al. | Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. | 1997 | Clin. Orthop. Relat. Res. | pmid:9137198 |
Granoff DM et al. | MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. | 1997 | Infect. Immun. | pmid:9125551 |
Gylling H et al. | Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. | 1996 | Atherosclerosis | pmid:9125314 |
Rangel H et al. | Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. | 1996 | Antimicrob. Agents Chemother. | pmid:9124841 |
Eisele B et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. | 1997 | J. Lipid Res. | pmid:9101437 |
Kushiro T et al. | In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. | 1997 | Biol. Pharm. Bull. | pmid:9084891 |
O'Hagan DT et al. | Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. | 1997 | Mol Med Today | pmid:9060004 |
Baum CL et al. | Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. | 1997 | J. Biol. Chem. | pmid:9045674 |