(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Safe S and Caldwell J | The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii. | 1975 | Can. J. Microbiol. | pmid:1116039 |
Voogt PA et al. | What about squalene in the earthworm Lumbricus terrestris? | 1975 | Comp. Biochem. Physiol., B | pmid:1122731 |
van Tamelen EE and Heys JR | Letter: Enzymic epoxidation of squalene variants. | 1975 | J. Am. Chem. Soc. | pmid:1133387 |
Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
Nestel PJ and Kudchodkar B | Plasma squalene as an index of cholesterol synthesis. | 1975 | Clin Sci Mol Med | pmid:1204294 |
Cunliffe WJ et al. | An explanation fro chloracne -- an industrial hazard. | 1975 | Acta Derm. Venereol. | pmid:50695 |
Tulliez J et al. | [The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism]. | 1975 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:807414 |
Scallen TJ et al. | Sterol carrier protein hypothesis: requirement for three substrate-specific soluble proteins in liver cholesterol biosynthesis. | 1975 | Life Sci. | pmid:165341 |
Ono T and Bloch K | Solubilization and partial characterization of rat liver squalene epoxidase. | 1975 | J. Biol. Chem. | pmid:234459 |
Strauss JS et al. | Skin lipids and acne. | 1975 | Annu. Rev. Med. | pmid:125065 |
Nurminen T et al. | Neutral lipids in the cells and cell envelope fractions of aerobic baker's yeast and anaerobic brewer's yeast. | 1975 | Chem. Phys. Lipids | pmid:1091369 |
Shimizu I and Katsuki H | Effect of temperature on ergosterol biosynthesis in yeast. | 1975 | J. Biochem. | pmid:1099086 |
Barton DH et al. | Investigations on the biosynthesis of steroids and terpenoids. Part XII. Biosynthesis of 3beta-hydroxy-triterpenoids and -steroids from (3S)-2,3-epoxy-2,3-dihydrosqualene. | 1975 | J. Chem. Soc. Perkin Trans. I | pmid:1099108 |
Moreau JP et al. | Biosynthesis of sterols by a yeast homogenate. Incorporation of mevalonic acid into cholesta-5,7,24-trien-3beta-ol and 5alpha-cholesta-7,24-dien-3beta-ol. | 1975 | Eur. J. Biochem. | pmid:1100393 |
Lewis RW | The squalene content of atheromatous plaques. A re-examination. | 1975 Nov-Dec | Atherosclerosis | pmid:1201156 |
Sanina OL and Datsenko ZM | [Sterol composition of sarcolemma in normal rabbits and in experimental muscular dystrophy]. | 1975 Nov-Dec | Ukr Biokhim Zh | pmid:1202710 |
Vendt VP | [Studies in the field of chemistry, biochemistry and photobiochemistry of sterols]. | 1975 Sep-Oct | Ukr Biokhim Zh | pmid:1105921 |
Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |
Bowden PE et al. | Effects of 5alpha-reduced androgens on preputial-gland size and lipogenic activity. | 1976 | Biochem. Soc. Trans. | pmid:1001770 |
Cooper MF et al. | Effects of testosterone and alpha-melanocyte-stimulating hormone on preputial-gland (sebaceous) activity. | 1976 | Biochem. Soc. Trans. | pmid:1001771 |
Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |
Gloor M et al. | Biochemical and physiological parameters on the healthy skin surface of patients with common warts. | 1976 | Dermatologica | pmid:939341 |
Srikantaiah MV et al. | Purification and properties of sterol carrier protein1. | 1976 | J. Biol. Chem. | pmid:965373 |
Grabowski GA et al. | Evidence for carrier proteins in bile acid synthesis. The effect of squalene and sterol carrier protein and albumin on the activity of 12alpha-hydroxylase. | 1976 | Biochim. Biophys. Acta | pmid:974090 |
Gloor M et al. | Biochemical and physiological parameters on the healthy skin surface of persons with candidal intertrigo and of persons with tinea cruris. | 1976 | Arch Dermatol Res | pmid:1008615 |
Bouissou H et al. | [Cutaneous cholesterol and phospholipids in atherosclerosis]. | 1976 | Paroi Arterielle | pmid:1012738 |
O'Neill HJ and Gershbein LL | Lipids of human and equine smegma. | 1976 | Oncology | pmid:1018879 |
Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
Kushwaha SC and Kates M | Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. | 1976 | Can. J. Biochem. | pmid:1252986 |
Liu GC et al. | Measurement of squalene in human tissues and plasma: validation and application. | 1976 | J. Lipid Res. | pmid:1255019 |
Righetti M et al. | The in vitro metabolism of mevalonate by sterol and non-sterol pathways. | 1976 | J. Biol. Chem. | pmid:1262340 |
Coates RM | Biogenetic-type rearrangements of terpenes. | 1976 | Fortschr Chem Org Naturst | pmid:791779 |
Ortiz de Montellano PR and Boparai AS | The squalene synthetase active site. Catalytic acceptance of 7- and 11- demethylfarnesyl pyrophosphates. | 1976 | Biochem. Biophys. Res. Commun. | pmid:800341 |
Beck FW and Whitehouse MW | Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. | 1976 | Agents Actions | pmid:822699 |
Trocha PJ and Sprinson DB | Location and regulation of early enzymes of sterol biosynthesis in yeast. | 1976 | Arch. Biochem. Biophys. | pmid:7207 |
BeytÃa ED and Porter JW | Biochemistry of polyisoprenoid biosynthesis. | 1976 | Annu. Rev. Biochem. | pmid:9026 |
Gloor M | [The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)]. | 1976 | Z. Hautkr. | pmid:13544 |
Ahrens EH | Sterol balance in hyperlipidemic patients after dietary exchange of carbohydrate for fat. | 1976 | J. Lipid Res. | pmid:1270936 |
Ortiz de Montellano PR et al. | Squalene biosynthesis. Role of the 3-methyl group in farnesyl pyrophosphate. | 1976 | J. Am. Chem. Soc. | pmid:177475 |
Lewis RW | Effect of alimentation on human serum squalene levels. | 1976 | Lipids | pmid:180373 |
Pye RJ et al. | Skin surface lipid composition in rosacea. | 1976 | Br. J. Dermatol. | pmid:130159 |
Cooper MF et al. | Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. | 1976 | Br. J. Dermatol. | pmid:130160 |
Kushwaha SC and Kates M | Lipid composition of Neurospora crassa. | 1976 | Lipids | pmid:136584 |
Cooper MF et al. | Sebaceous lipogenesis and androgen metabolism in acne. | 1976 | Biochem. Soc. Trans. | pmid:137154 |
Ernst J et al. | The crystal structure of squalene. | 1976 | Angew. Chem. Int. Ed. Engl. | pmid:827944 |
Kohashi O and Pearson CM | Arthritogenicity of Mycobacterium smegmatis subfractions, related to different oil vehicle and different composition. | 1976 | Int. Arch. Allergy Appl. Immunol. | pmid:1085757 |
Saat YA and Bloch KE | Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase. | 1976 | J. Biol. Chem. | pmid:956181 |
Bell FP | Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate. | 1976 | Lipids | pmid:994746 |