(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |
| Novoselova EG and KolomiÄtseva IK | [Early radiation impairments of the metabolism of cholesterol, squalene and ubiquinone in rat liver]. | 1976 Jul-Aug | Radiobiologiia | pmid:996254 |
| Volkov GL et al. | [In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. | 1976 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:1005362 |
| Boar RB and Damps K | Resolution of 2,3-dihydrosqualene-2,3-diol, 10,11-dihydro-10,11-dihydroxyfarnesyl benzoate, and 6,7-dihydro-6,7-dihydroxygeranyl benzoate. Synthesis of (3R)- and (3S)-2,3-epoxy-2,3-dihydrosqualene. | 1977 | J. Chem. Soc. Perkin Trans. I | pmid:558213 |
| Wiss O and Wiss V | The influence of fasting on the synthesis of cholesterol, squalene, fatty acids, and ubiquinones in liver, small intestine, and kidney of rats in vivo. | 1977 | Helv. Chim. Acta | pmid:599042 |
| Wiss O and Wiss V | On the influence of cholesterol feeding and of a lipogenic diet on the cholesterogenesis in rat liver in vivo. | 1977 | Helv. Chim. Acta | pmid:599043 |
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| Wiss O and Wiss V | On metabolic degradations of squalene, lanosterol and cholesterol in rat liver in vivo. Evidence for recycling of metabolites for the synthesis of isoprene compounds. | 1977 | Helv. Chim. Acta | pmid:914630 |
| Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
| Karst F and Lacroute F | Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. | 1977 | Mol. Gen. Genet. | pmid:200835 |
| Gollub EG et al. | Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. | 1977 | J. Biol. Chem. | pmid:323256 |
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| Popják G | "As I remember it" research on biosynthesis of fatty acids, triglycerides, squalene, and cholesterol. | 1977 | J Am Oil Chem Soc | pmid:328555 |
| Kohashi O et al. | Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. | 1977 | Infect. Immun. | pmid:302240 |
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| Phleger CF et al. | Membrane biosynthesis in swimbladders of deep sea fishes Coryphaenoides acrolepis and Antimora rostrata. | 1977 | Comp. Biochem. Physiol., B | pmid:830467 |
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| Tornabene TG | Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. | 1978 | J. Mol. Evol. | pmid:691076 |
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| Nishino T et al. | Synthesis of dehydrosqualene in microsomal fraction of Saccharomyces cerevisiae. | 1978 | Biochem. Biophys. Res. Commun. | pmid:32886 |
| Yamawaki M et al. | Antitumor activity of squalene-treated cell-wall skeleton of Nocardia rubra in mice. | 1978 | Gan | pmid:103768 |
| Patt TE and Hanson RS | Intracytoplasmic membrane, phospholipid, and sterol content of Methylobacterium organophilum cells grown under different conditions. | 1978 | J. Bacteriol. | pmid:96093 |
| Goldberg I and Shechter I | Occurrence of squalene in methanol-grown bacteria. | 1978 | J. Bacteriol. | pmid:98521 |
| Weeks OB and Francesconi MD | Occurrence of squalene and sterols in Cellulomonas dehydrogenans (Arnaudi 1942) comb. nov. Hester 1971. | 1978 | J. Bacteriol. | pmid:101527 |
| Bertolino A et al. | Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. | 1978 | Biochim. Biophys. Acta | pmid:210830 |
| Strauss JS et al. | Surface lipid composition in children with protein-calorie malnutrition. | 1978 | Am. J. Clin. Nutr. | pmid:414616 |