(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
Chen JS et al. | Osmometric and microscopic studies on bilayers of polar lipids from the extreme halophile, Halobacterium cutirubrum. | 1974 | Biochim. Biophys. Acta | pmid:4407051 |
Gloor M et al. | [Inferior function of the skin as a key factor in the development of spinalioma (author's transl)]. | 1974 | Arch Dermatol Forsch | pmid:4407434 |
Ebersole RC et al. | Mechanism of oxidative cyclization of squalene. Concerning the mode of formation on the 17(20) double bond in the biosynthesis of fusidic acid by Fusidium coccineum. | 1974 | J. Am. Chem. Soc. | pmid:4414613 |
Frayha GJ | Synthesis of certain cholesterol precursors by hydatid protoscoleces of Echinococcus granulosus and cysticerci of Taenia hydatigena. | 1974 | Comp. Biochem. Physiol., B | pmid:4416028 |
Nagai J et al. | Effects of thiamine and pyridoxine on the content and composition of sterols in Saccharomyces carlsbergensis 4228. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4418731 |
Nikkari T et al. | In vivo studies of sterol and squalene secretion by human skin. | 1974 | J. Lipid Res. | pmid:4430879 |
Benoy CJ et al. | Enhancement of the cancer chemotherapeutic effect of the cell cycle phase specific agents methotrexate and cytosine arabinoside when given as a water-oil-water emulsion. | 1974 | Eur J Cancer | pmid:4435002 |
Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
Ramsey RB et al. | The effect of non-ionic detergents and phospholipase A on enzymes involved in adult rat brain sterol biosynthesis from (2-14C)-mevalonic acid in vitro. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4441393 |
Johnson RC and Shah SN | Hepatic cholesterol synthesis from mevalonate and squalwne in rats: effect of feeding cholesterol supplemented diet during weaning and following starvation. | 1974 | Lipids | pmid:4444430 |
Gutfinger T and Letan A | Quantitative changes in some unsaponifiable components of soya bean oil due to refining. | 1974 | J. Sci. Food Agric. | pmid:4473685 |
Dam H et al. | Alimentary production of gallstones in hamsters. 27. Influence of supplementation of the gallstone producing diet with squalene, cholesterol, certain other sterols, fish oil fatty acid ethyl esters, and modification of the basal diet on gallstone production and levels of cholesterol in serum and liver. | 1974 | Z Ernahrungswiss | pmid:4615449 |
Scallen TJ et al. | Proceedings: Sterol carrier protein hypothesis. | 1974 | Fed. Proc. | pmid:4827525 |
Dediukhina EG and Eroshin VK | [Hydrocarbon biosynthesis by microorganisms]. | 1973 Nov-Dec | Usp Sovrem Biol | pmid:4593530 |
Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
Terakado M et al. | Effects of arsenite on incorporation of mevalonate-2-14C into squalene-14C in rabbit dental pulp. | 1973 | J Nihon Univ Sch Dent | pmid:4517364 |
Anding C et al. | [Comparative cyclization of 2,3 epoxide of methylene-22-dihydro-22-squalene in cell-free systems extracted from animal and higher plant tissues]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4632903 |
Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
Bose AK and Hungund BL | The role of glycine in the biosynthesis of steroids. | 1973 | Experientia | pmid:4582087 |
David MH and Kirsop BH | A correlation between oxygen requirements and the products of sterol synthesis in strains of Saccharomyces cerevisiae. | 1973 | J. Gen. Microbiol. | pmid:4584066 |
Clark RP and Shirley SG | Identification of skin in airborne particulate matter. | 1973 | Nature | pmid:4585846 |
Johnson RC and Shah SN | Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4741538 |
Egwim PO and Kummerow FA | In vitro hepatic cholesterogenesis in rats fed corn oil and fat-free diets. | 1973 | Life Sci. II | pmid:4708203 |
Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
Shah SN | Regulation of hepatic cholesterol synthesis from mevalonate in suckling and weaned rats. | 1973 | Lipids | pmid:4713377 |
Phleger CF et al. | Pressure effect on squalene-2,3-oxide cyclization in fish. | 1973 | Comp. Biochem. Physiol., B | pmid:4719990 |
van Leusden HA et al. | Lack of squalene and lanosterol synthesis by the perfused human placenta at term. | 1973 | J. Steroid Biochem. | pmid:4747979 |
Farrington JW et al. | Intercalibration of analyses of recently biosynthesized hydrocarbons and petroleum hydrocarbons in marine lipids. | 1973 | Bull Environ Contam Toxicol | pmid:4753263 |
Murakami S | Isolation and analysis of squalene alcohols from rat preputial glands. | 1973 | Kobe J Med Sci | pmid:4764042 |
Hellstrom KH et al. | Studies of the in vivo metabolism of mevalonic acid in the normal rat. | 1973 | J. Clin. Invest. | pmid:4703220 |
Qureshi AA et al. | Squalene synthetase. II. Purification and properties of bakers' yeast enzyme. | 1973 | J. Biol. Chem. | pmid:4348552 |
Beytia E et al. | Squalene synthetase. 3. Mechanism of the reaction. | 1973 | J. Biol. Chem. | pmid:4348553 |
Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
Morris PW and Gorski J | Control of steroidogenesis in pre-ovulatory cells. Luteinizing hormone stimulation of (14C)-acetate incorporation into sterols. | 1973 | J. Biol. Chem. | pmid:4355508 |
Derksen A and Cohen P | Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. | 1973 | J. Biol. Chem. | pmid:4355579 |
Inomata N | [Symposium I: aging and the activity of the sebaceous glands]. | 1973 | Nihon Hifuka Gakkai Zasshi | pmid:4546667 |
Faulkner DJ and Petersen MR | Application of the claisen rearrangement to the synthesis of trans trisubstituted olefinic bonds. Synthesis of squalene and insect juvenile hormone. | 1973 | J. Am. Chem. Soc. | pmid:4687674 |
Caspi E et al. | Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid. | 1973 | J. Steroid Biochem. | pmid:4795867 |
Ebersole RC et al. | Mechanism of oxidative cyclization of squalene. Evidence for cyclization of squalene from either end of the squalene molecule in the in vivo biosynthesis of fusidic acid by Fusidium coccineum. | 1973 | J. Am. Chem. Soc. | pmid:4796972 |
Kellum RE et al. | Human sebaceous gland lipids: in vitro incubations with 14C-labelled compounds. | 1973 | J. Invest. Dermatol. | pmid:4684160 |
Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
Bhavani BR and Short RV | Formation of steroids by the pregnant mare. 3. Metabolism of 14C-squalene and 3H-dehydroisoandrosterone injected into the fetal circulation. | 1973 | Endocrinology | pmid:4267110 |
Williams M et al. | The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. | 1973 | Br. J. Dermatol. | pmid:4270005 |
Gloor M et al. | [Composition of skin surface lipids in persons with seborrhoea sicca and seborrhoea oleosa (author's transl)]. | 1973 | Arch Dermatol Forsch | pmid:4270568 |
Cunliffe WJ et al. | Tetracycline and acne vulgaris: a clinical and laboratory investigation. | 1973 | Br Med J | pmid:4271323 |
Cotterill JA et al. | Variation in skin surface lipid composition and sebum excretion rate with time. | 1973 | Acta Derm. Venereol. | pmid:4127454 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in mollusca. X. Biosynthesis and composition of 3 beta-sterols in Cephalopoda. | 1973 | Arch. Int. Physiol. Biochim. | pmid:4127479 |
Qureshi AA et al. | Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase. | 1973 | J. Biol. Chem. | pmid:4144543 |
Kawaguchi A et al. | Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. | 1973 | Biochim. Biophys. Acta | pmid:4120185 |