(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morimoto Y et al. | Asymmetric total synthesis of highly symmetric squalene-derived cytotoxic polyethers. | 2002 | Chirality | pmid:12112332 |
| Hoshino T and Ohashi S | Importance of the methyl group at C10 of squalene for hopene biosynthesis and novel carbocyclic skeletons with 6/5 + 5/5 + (6) ring system(s). | 2002 | Org. Lett. | pmid:12123374 |
| Asa PB et al. | Antibodies to squalene in recipients of anthrax vaccine. | 2002 | Exp. Mol. Pathol. | pmid:12127050 |
| Asano KG et al. | Chemical composition of fingerprints for gender determination. | 2002 | J. Forensic Sci. | pmid:12136987 |
| Pérez-Camino MC et al. | Determination of esters of fatty acids with low molecular weight alcohols in olive oils. | 2002 | J. Agric. Food Chem. | pmid:12137504 |
| Jarstfer MB et al. | Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH. | 2002 | J. Am. Chem. Soc. | pmid:12137536 |
| Blagg BS et al. | Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. | 2002 | J. Am. Chem. Soc. | pmid:12137537 |
| Matyas GR et al. | Induction and detection of antibodies to squalene. II. Optimization of the assay for murine antibodies. | 2002 | J. Immunol. Methods | pmid:12165433 |
| Connolly JD and Hill RA | Triterpenoids. | 2002 | Nat Prod Rep | pmid:12195814 |
| Hess BA | Concomitant C-ring Expansion and D-ring formation in lanosterol biosynthesis from squalene without violation of Markovnikov's rule. | 2002 | J. Am. Chem. Soc. | pmid:12197724 |
| Rontani JF et al. | Aerobic and anaerobic metabolism of squalene by a denitrifying bacterium isolated from marine sediment. | 2002 | Arch. Microbiol. | pmid:12209261 |
| Skeiky YA et al. | Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. | 2002 | Vaccine | pmid:12213399 |
| Yoo YC et al. | Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice. | 2002 | Arch. Pharm. Res. | pmid:12214866 |
| Wentzinger LF et al. | Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. | 2002 | Plant Physiol. | pmid:12226513 |
| Gylling H and Miettinen TA | Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. | 2002 | J. Lipid Res. | pmid:12235179 |
| Rastrelli L et al. | Rate of degradation of alpha-tocopherol, squalene, phenolics, and polyunsaturated fatty acids in olive oil during different storage conditions. | 2002 | J. Agric. Food Chem. | pmid:12236680 |
| Bernier UR et al. | Chemical analysis of human skin emanations: comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae). | 2002 | J. Am. Mosq. Control Assoc. | pmid:12322940 |
| Ley JP et al. | 3,4-Dihydroxymandelic acid, a noradrenalin metabolite with powerful antioxidative potential. | 2002 | J. Agric. Food Chem. | pmid:12358456 |
| Quang DN et al. | Concentriols B, C and D, three squalene-type triterpenoids from the ascomycete Daldinia concentrica. | 2002 | Phytochemistry | pmid:12359521 |
| Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
| Zhang Z et al. | Effect of squalene and shark liver oil on serum cholesterol level in hamsters. | 2002 | Int J Food Sci Nutr | pmid:12396466 |
| Hauss T et al. | Squalane is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier. | 2002 | Biochim. Biophys. Acta | pmid:12460672 |
| Ostlund RE et al. | Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. | 2002 | Nutr. Rev. | pmid:12462517 |
| Clouse SD | Brassinosteroids. Plant counterparts to animal steroid hormones? | 2002 | Vitam. Horm. | pmid:12481548 |
| Dembitsky VM and Srebnik M | Variability of hydrocarbon and fatty acid components in cultures of the filamentous cyanobacterium Scytonema sp. isolated from microbial community "black cover" of limestone walls in Jerusalem. | 2002 | Biochemistry Mosc. | pmid:12495426 |
| Strauss JS et al. | Skin lipids and acne. | 1975 | Annu. Rev. Med. | pmid:125065 |
| Lee KT et al. | Structure of three new terpenoids, spiciformisins a and b, and monocyclosqualene, isolated from the herbs of Ligularia fischeri var. spiciformis and cytotoxicity. | 2002 | Arch. Pharm. Res. | pmid:12510832 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |
| Kushwaha SC and Kates M | Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. | 1976 | Can. J. Biochem. | pmid:1252986 |
| Khallouki F et al. | Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. | 2003 | Eur. J. Cancer Prev. | pmid:12548113 |
| Liu GC et al. | Measurement of squalene in human tissues and plasma: validation and application. | 1976 | J. Lipid Res. | pmid:1255019 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Ballou WR et al. | Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. | 2003 | J. Infect. Dis. | pmid:12599085 |
| Ketomäki A et al. | Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. | 2003 | Pediatr. Res. | pmid:12612218 |
| Righetti M et al. | The in vitro metabolism of mevalonate by sterol and non-sterol pathways. | 1976 | J. Biol. Chem. | pmid:1262340 |
| Stephenson I et al. | Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. | 2003 | Vaccine | pmid:12639491 |
| Souto ML et al. | The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12657259 |
| Luan Z et al. | Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663370 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Banzhoff A et al. | A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis. | 2003 May-Jun | Gerontology | pmid:12679609 |
| Hendler RW et al. | Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity. | 2003 | Eur. J. Biochem. | pmid:12709050 |
| Ahrens EH | Sterol balance in hyperlipidemic patients after dietary exchange of carbohydrate for fat. | 1976 | J. Lipid Res. | pmid:1270936 |
| Lu HT et al. | Preparative separation and purification of squalene from the microalga Thraustochytrium ATCC 26185 by high-speed counter-current chromatography. | 2003 | J Chromatogr A | pmid:12779217 |
| Chiba K et al. | Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784064 |
| Rocco F et al. | Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases. | 2003 | Lipids | pmid:12784859 |
| Ekanayake Mudiyanselage S et al. | Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo. | 2003 | J. Invest. Dermatol. | pmid:12787115 |
| Madani KA | Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. | 2003 | Nutr. Rev. | pmid:12795450 |