(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen JS et al. | Osmometric and microscopic studies on bilayers of polar lipids from the extreme halophile, Halobacterium cutirubrum. | 1974 | Biochim. Biophys. Acta | pmid:4407051 |
| NICHOLAS HJ and THOMAS BE | Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. | 1959 | Biochim. Biophys. Acta | pmid:13854106 |
| Matyas GR et al. | Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. | 2009 | Biochim. Biophys. Acta | pmid:19100711 |
| Taramino S et al. | Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. | 2010 | Biochim. Biophys. Acta | pmid:19879375 |
| Kramer JK et al. | Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. | 1972 | Biochim. Biophys. Acta | pmid:5037322 |
| Perzl M et al. | Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. | 1998 | Biochim. Biophys. Acta | pmid:9714766 |
| HOLMES WL and STACK E | Gas chromatography of squalene, sterols and bile acid methyl esters. | 1962 | Biochim. Biophys. Acta | pmid:13908533 |
| MARKLEY K and GURIN S | Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. | 1959 | Biochim. Biophys. Acta | pmid:13628647 |
| Shafai T and Lewin LM | Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. | 1968 | Biochim. Biophys. Acta | pmid:4298231 |
| Ono T et al. | Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system. | 1977 | Biochim. Biophys. Acta | pmid:403952 |
| Rees HH et al. | 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. | 1969 | Biochim. Biophys. Acta | pmid:5797101 |
| Pascaud A et al. | [Turnover of the endogenous free cholesterol of the hepatic cell plasma membrane sinusoids]. | 1979 | Biochimie | pmid:534664 |
| Dosio F et al. | Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation. | 2010 | Bioconjug. Chem. | pmid:20597546 |
| Passi S et al. | The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. | 2003 | Biofactors | pmid:14695946 |
| Pasechnik VI | [Cooperative analysis of measurements of capacity and optical parameters of bilayer lipid membranes]. | 1983 Jan-Feb | Biofizika | pmid:6830905 |
| Ivashkevich SP et al. | [Effects of sterols having different chemical structure and squalene on osmotic resistance of erythrocytes]. | 1981 | Biokhimiia | pmid:7272362 |
| Davis TA et al. | Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. | 2001 | Biol. Blood Marrow Transplant. | pmid:11669219 |
| Zauner W et al. | Defined synthetic vaccines. | 2001 | Biol. Chem. | pmid:11405222 |
| Wysocki SJ et al. | Lipids in forehead vernix from newborn infants. | 1981 | Biol. Neonate | pmid:7260215 |
| Ryu A et al. | Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. | 2009 | Biol. Pharm. Bull. | pmid:19721223 |
| Kushiro T et al. | In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. | 1997 | Biol. Pharm. Bull. | pmid:9084891 |
| Uchino T et al. | Effect of squalene monohydroperoxide on cytotoxicity and cytokine release in a three-dimensional human skin model and human epidermal keratinocytes. | 2002 | Biol. Pharm. Bull. | pmid:12033500 |
| Piotrowski PC et al. | Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | 2006 | Biol. Reprod. | pmid:16571871 |
| Palma P et al. | Safety and immunogenicity of a monovalent MF59®-adjuvanted A/H1N1 vaccine in HIV-infected children and young adults. | 2012 | Biologicals | pmid:22261282 |
| Trung Bui D et al. | Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. | 2013 | Biomacromolecules | pmid:23829862 |
| Chen WL et al. | Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide. | 2014 | Biomaterials | pmid:24268203 |
| Xiao L et al. | The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. | 2010 | Biomaterials | pmid:20488530 |
| Kawakami T et al. | Squalane as a possible carrier of bone morphogenetic protein. | 1993 | Biomaterials | pmid:8399948 |
| Hillaireau H et al. | Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies. | 2013 | Biomaterials | pmid:23562054 |
| Emmons GT et al. | Effects of 20,25-diazacholesterol on cholesterol synthesis in cultured chick muscle cells: a radiogas chromatographic and mass spectrometric study of the post-squalene sector. | 1982 | Biomed. Mass Spectrom. | pmid:7126761 |
| Yoshino S | Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. | 1996 | Biomed. Pharmacother. | pmid:8672728 |
| Kuroda Y et al. | Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. | 2004 | Biomed. Pharmacother. | pmid:15194169 |
| Viola F et al. | Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors. | 2000 | Bioorg. Med. Chem. | pmid:10968281 |
| Gerpe A et al. | 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. | 2009 | Bioorg. Med. Chem. | pmid:19811923 |
| Fernández JJ et al. | Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. | 1998 | Bioorg. Med. Chem. | pmid:9925286 |
| Gerpe A et al. | Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. | 2008 | Bioorg. Med. Chem. | pmid:17981471 |
| Galli U et al. | Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17027267 |
| Caron J et al. | Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20363623 |
| Watanabe T et al. | Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20728352 |
| Jagadish B et al. | Squalene-derived flexible linkers for bioactive peptides. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17448660 |
| Souto ML et al. | The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12657259 |
| Heinemann SH and Sigworth FJ | Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. | 1990 | Biophys. J. | pmid:1689592 |
| White SH | Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene. | 1978 | Biophys. J. | pmid:698340 |
| Lapointe JY and Laprade R | Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. | 1982 | Biophys. J. | pmid:6896832 |
| Simon SA et al. | The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. | 1977 | Biophys. J. | pmid:880329 |
| Salamon Z et al. | Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties. | 1997 | Biophys. J. | pmid:9370473 |
| Armstrong KM and Cukierman S | On the origin of closing flickers in gramicidin channels: a new hypothesis. | 2002 | Biophys. J. | pmid:11867449 |
| Crilly JF and Earnshaw JC | Photon correlation spectroscopy of bilayer lipid membranes. | 1983 | Biophys. J. | pmid:6838962 |
| Bach D and Miller IR | Glyceryl monooleate black lipid membranes obtained from squalene solutions. | 1980 | Biophys. J. | pmid:7053057 |
| Nakazawa A et al. | Optimization of culture conditions of the thraustochytrid Aurantiochytrium sp. strain 18W-13a for squalene production. | 2012 | Bioresour. Technol. | pmid:22023965 |