(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Rangel H et al. | Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. | 1996 | Antimicrob. Agents Chemother. | pmid:9124841 |
Gylling H et al. | Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. | 1996 | Atherosclerosis | pmid:9125314 |
Granoff DM et al. | MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. | 1997 | Infect. Immun. | pmid:9125551 |
Kawakami T et al. | Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. | 1997 | Clin. Orthop. Relat. Res. | pmid:9137198 |
Perzl M et al. | Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. | 1997 | Microbiology (Reading, Engl.) | pmid:9141686 |
Wiss O and Wiss V | On metabolic degradations of squalene, lanosterol and cholesterol in rat liver in vivo. Evidence for recycling of metabolites for the synthesis of isoprene compounds. | 1977 | Helv. Chim. Acta | pmid:914630 |
Morand OH et al. | Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. | 1997 | J. Lipid Res. | pmid:9162756 |
Kuchta T et al. | Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. | 1997 | FEMS Microbiol. Lett. | pmid:9163904 |
Fliesler SJ et al. | Squalene is localized to the plasma membrane in bovine retinal rod outer segments. | 1997 | Exp. Eye Res. | pmid:9176062 |
Flint OP et al. | Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221828 |
Barnett SW et al. | Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. | 1997 | Vaccine | pmid:9234536 |
Cenedella RJ | Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. | 1997 | Exp. Eye Res. | pmid:9237866 |
Hamdan JS and Casali AK | Effect of amphotericin B on the lipids of yeast cells of Sporothrix schenckii. | 1996-1997 | Mycopathologia | pmid:9276941 |
Donald KA et al. | Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. | 1997 | Appl. Environ. Microbiol. | pmid:9292983 |
Wendt KU et al. | Structure and function of a squalene cyclase. | 1997 | Science | pmid:9295270 |
Uusitupa MI et al. | Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran. | 1997 | Eur J Clin Nutr | pmid:9306087 |
Grieveson LA et al. | A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene. | 1997 | Anal. Biochem. | pmid:9324936 |
Mansfield PD et al. | The effects of four, commercial ceruminolytic agents on the middle ear. | 1997 Nov-Dec | J Am Anim Hosp Assoc | pmid:9358414 |
Cornforth JW | Asymmetry and enzyme action. | 1976 | Science | pmid:935862 |
Edmond J et al. | Mevalonate metabolism: role of kidneys. | 1976 | Science | pmid:935865 |