(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schroepfer GJ | Sterol biosynthesis. | 1981 | Annu. Rev. Biochem. | pmid:7023367 |
Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
BeytÃa ED and Porter JW | Biochemistry of polyisoprenoid biosynthesis. | 1976 | Annu. Rev. Biochem. | pmid:9026 |
Strauss JS et al. | Skin lipids and acne. | 1975 | Annu. Rev. Med. | pmid:125065 |
Bibikova MV and Bondareva NS | [Drugs of microbial origin for treatment of atherosclerosis]. | 1998 | Antibiot. Khimioter. | pmid:9777104 |
Reddy LH et al. | Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms. | 2008 | Anticancer Drugs | pmid:18827565 |
Rangel H et al. | Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. | 1996 | Antimicrob. Agents Chemother. | pmid:9124841 |
Buckner FS et al. | Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors. | 2001 | Antimicrob. Agents Chemother. | pmid:11257036 |
Ryder NS et al. | Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. | 1984 | Antimicrob. Agents Chemother. | pmid:6375557 |