(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Coronavirus Infections D018352 4 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Viremia D014766 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Boutaud O et al. Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. 1995 Biochem. Biophys. Res. Commun. pmid:7887959
Fujita H and Matsuo I In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials. 1994 Photodermatol Photoimmunol Photomed pmid:7880759
Someya K et al. The antioxidant effect of palm fruit carotene on skin lipid peroxidation in guinea pigs as estimated by chemiluminescence-HPLC method. 1994 J. Nutr. Sci. Vitaminol. pmid:7844638
Rabiskova M et al. The influence of surface properties on uptake of oil into complex coacervate microcapsules. 1994 J. Pharm. Pharmacol. pmid:7815274
Balliano G et al. Inhibition of sterol biosynthesis in Saccharomyces cerevisiae and Candida albicans by 22,23-epoxy-2-aza-2,3-dihydrosqualene and the corresponding N-oxide. 1994 Antimicrob. Agents Chemother. pmid:7810997
Cattel L et al. 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. 1995 Lipids pmid:7791532
Abe I and Prestwich GD Identification of the active site of vertebrate oxidosqualene cyclase. 1995 Lipids pmid:7791531
Lees ND et al. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. 1995 Lipids pmid:7791529
Kamimura N et al. Construction of squalene-accumulating Saccharomyces cerevisiae mutants by gene disruption through homologous recombination. 1994 Appl. Microbiol. Biotechnol. pmid:7765777
Yamamoto A et al. Impaired water barrier function in acne vulgaris. 1995 Arch. Dermatol. Res. pmid:7763094
Langenberg AG et al. A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity [corrected]. 1995 Ann. Intern. Med. pmid:7755223
Houston L et al. Response of guinea pigs to a vaccine containing a new adjuvant (SAF) and gram-negative bacteria. 1995 Lab. Anim. Sci. pmid:7752616
Fliesler SJ et al. Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. 1995 Exp. Eye Res. pmid:7720806
Kerwin JL et al. Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. 1995 Microbiology (Reading, Engl.) pmid:7704271
Gylling H et al. Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. 1995 Atherosclerosis pmid:7669084
Vanhanen HT and Miettinen TA Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. 1995 Atherosclerosis pmid:7661873
Pittler SJ et al. In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. 1995 J. Cell Biol. pmid:7615641
Nagumo A et al. Purification and characterization of recombinant squalene epoxidase. 1995 J. Lipid Res. pmid:7595073
Viola F et al. Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. 1995 Biochem. Pharmacol. pmid:7575639
Ott G et al. MF59. Design and evaluation of a safe and potent adjuvant for human vaccines. 1995 Pharm Biotechnol pmid:7551221
Yoshino S and Yoshino J Recruitment of pathogenic T cells to synovial tissues of rats injected intraarticularly with nonspecific agents. 1994 Cell. Immunol. pmid:7522973
PerederiÄ­ OF and Morozova RP [Squalene and sterols of rat stomach tissue and the effect of acetylsalicylic acid on their content]. 1978 Nov-Dec Ukr. Biokhim. Zh. pmid:749299
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Robuccio JA et al. Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs. 1995 Lab. Anim. Sci. pmid:7474883
Soloway AH and LeQuesne PW Potential endogenous mutagens/carcinogens. 1980 J. Theor. Biol. pmid:7464159
Morin RJ and Srikantaiah MV In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol. 1980 J. Lipid Res. pmid:7462811
Rohmer M et al. Non-specific biosynthesis of hopane triterpenes by a cell-free system from Acetobacter pasteurianum. 1980 Eur. J. Biochem. pmid:7460938
Nelson JA et al. Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide. 1981 J. Biol. Chem. pmid:7451488
Srikantaiah MV et al. Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins. 1980 Lipids pmid:7432102
Matsumoto G and Hanya T Presence of squalane in urban aquatic environments. 1980 J. Chromatogr. pmid:7410506
Friedlander EJ et al. Supernatant protein factor facilitates intermembrane transfer of squalene. 1980 J. Biol. Chem. pmid:7410347
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Caras IW et al. Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. 1980 J. Biol. Chem. pmid:7364757
Falcone DJ et al. Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. 1980 Am. J. Pathol. pmid:7361865
Bell FP Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. 1980 Bull Environ Contam Toxicol pmid:7357111
Strandberg TE et al. Squalene and sterol synthesis in isolated small-intestinal cells of the rat. 1981 Scand. J. Gastroenterol. pmid:7323711
Miettinen TA and Tilvis RS Cholesterol synthesis and storage in adipose tissue. 1981 Int J Obes pmid:7319685
Miettinen TA and Tilvis R Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. 1981 Scand. J. Clin. Lab. Invest. pmid:7313530
Mironova VN and Chaialo PP [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. 1978 Biull Eksp Biol Med pmid:728610
Downing DT et al. Estimation of sebum production rates in man by measurement of the squalene content of skin biopsies. 1981 J. Invest. Dermatol. pmid:7276619
McGinley KJ et al. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. 1980 J. Clin. Microbiol. pmid:7276142
Ivashkevich SP et al. [Effects of sterols having different chemical structure and squalene on osmotic resistance of erythrocytes]. 1981 Biokhimiia pmid:7272362
Tornabene TG Formation of hydrocarbons by bacteria and algae. 1981 Basic Life Sci. pmid:7271715
Carelli C et al. Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil. 1981 Infect. Immun. pmid:7263069
Wysocki SJ et al. Lipids in forehead vernix from newborn infants. 1981 Biol. Neonate pmid:7260215
Kojima Y et al. Protein-facilitated intermembrane transfer of squalene. Demonstration by density gradient centrifugation. 1981 J. Biol. Chem. pmid:7251595
Ito M et al. Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. 1981 Cancer Res. pmid:7248952
Hunter MI et al. The effect of temperature on the growth and lipid composition of the extremely halophilic coccus, Sarcina marina. 1981 Antonie Van Leeuwenhoek pmid:7247392
Anisimov MM et al. [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. 1978 Jul-Aug Prikl. Biokhim. Mikrobiol. pmid:724665