(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Viremia D014766 4 associated lipids
Lipodystrophy D008060 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Alopecia Areata D000506 6 associated lipids
Chronic Disease D002908 7 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Jones JP et al. Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: sterol formation. 1971 Life Sci. II pmid:5569686
Peter G et al. [Gas-chromatography studies on sebaceous gland lipids. II. Composition of sebaceous gland lipids in various age groups]. 1971 Arch Dermatol Forsch pmid:5560856
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods. 1971 Lipids pmid:5559874
Cunliffe WJ et al. Variations in skin surface lipid composition with different sampling techniques. I. 1971 Br. J. Dermatol. pmid:5557833
Cotterill JA et al. A semiquantitative method for the biochemical analysis of sebum. 1971 Br. J. Dermatol. pmid:5557832
Mulheirn LJ and Caspi E Mechanism of squalene cyclization. The biosynthesis of fusidic acid. 1971 J. Biol. Chem. pmid:5553407
Coates RM and Robinson WH Stereoselective total synthesis of (plus or minus)-presqualene alcohol. 1971 J. Am. Chem. Soc. pmid:5550252
Altman LJ et al. Synthesis and conversion of presqualene alcohol to squalene. 1971 J. Am. Chem. Soc. pmid:5550251
Corey EJ et al. Conversion of des-6-methyl-2,3-oxidosqualene to 19-norlanosterol by 2,3-oxidosqualene-sterol cyclase. 1971 J. Am. Chem. Soc. pmid:5548348
Aaronson S Inhibition of yeast multiplication by hypocholesteremic compounds and its annulment by lipids. 1971 Proc. Soc. Exp. Biol. Med. pmid:5540639
Brooks CJ et al. Lipids of human atheroma. VI. Hydrocarbons of the atheromatous plaque. 1970 Lipids pmid:5488810
Pochi PE et al. Sebaceous gland response in man to prolonged total caloric deprivation. 1970 J. Invest. Dermatol. pmid:5483834
el-Ibrashy MT and Mansour MH Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae. 1970 Experientia pmid:5483755
Peter G et al. [Gas chromatographic examinations of sebaceous gland lipids. I. Total lipid determination]. 1970 Arch Klin Exp Dermatol pmid:5477881
Miettinen TA et al. Serum squalene and methyl sterols. 1970 N. Engl. J. Med. pmid:5470273
Villee CA Shark oil and medicine. 1970 N. Engl. J. Med. pmid:5462581
Caspi E and Mulheirn LJ Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid. 1970 J. Am. Chem. Soc. pmid:5460747
Godinez MH et al. The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. 1970 Arch. Biochem. Biophys. pmid:5460184
Corey EJ and Yamamoto H Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. 1970 Tetrahedron Lett. pmid:5447652
Rahman R et al. Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. 1970 J. Biol. Chem. pmid:5445804
Zander JM et al. Tetrahymanol biosynthesis. Studies in vitro on squalene cyclization. 1970 J. Biol. Chem. pmid:5442819
Gallin JI et al. Increased serum levels of seualene in patients with acute influenza. 1970 N. Engl. J. Med. pmid:5442630
Yamamoto S and Bloch K Studies on squalene epoxidase of rat liver. 1970 J. Biol. Chem. pmid:5438357
Phytochemistry: terpenoids for progress. 1970 Nature pmid:5437511
van Tamelen EE et al. Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10'-norsqualene 2,3-oxide. 1970 J. Am. Chem. Soc. pmid:5435278
Jayme M et al. The nature of the hydrogen migrations in the cyclization of squalene oxide to lanosterol. 1970 J. Am. Chem. Soc. pmid:5435274
Stefanovich V and Kajiyama G Squalene and cholestanol in normal rabbit aorta. 1970 May-Jun Atherosclerosis pmid:5433085
Sargent JR et al. Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. 1970 Biochem. J. pmid:5420034
Sloviter HA et al. Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. 1970 J. Lipid Res. pmid:5418482
Ramasastry P et al. Chemical composition of human skin surface lipids from birth to puberty. 1970 J. Invest. Dermatol. pmid:5414607
Robinson DR and West CA Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. I. Identification of diterpene hydrocarbons formed from mevalonate. 1970 Biochemistry pmid:5411208
Kushwaha SC and Kates M Studies of the biosynthesis of C50 carotenoids in Halobacterium cutirubrum. 1979 Can. J. Microbiol. pmid:540255
Kushwaha SC and Kates M Effect of glycerol on carotenogenesis in the extreme halophile, Halobacterium cutirubrum. 1979 Can. J. Microbiol. pmid:540254
Schlösser E et al. Sterols in species of Pythium. 1969 Arch Mikrobiol pmid:5384630
Eneroth P et al. Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium. 1969 Eur. J. Biochem. pmid:5368336
Lewis RW Distribution of dietary squalene in a wandering Albatross, diomedea exultans. 1969 Nature pmid:5358352
Ramm PJ and Caspi E The stereochemistry of tritium at carbon atoms 1, 7, and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. 1969 J. Biol. Chem. pmid:5350956
Partin JC and Schubert WK Small intestinal mucosa in cholesterol ester storage disease. A light and electron microscope study. 1969 Gastroenterology pmid:5348089
Downing DT et al. Variability in the chemical composition of human skin surface lipids. 1969 J. Invest. Dermatol. pmid:5347411
Pascaud A et al. [Turnover of the endogenous free cholesterol of the hepatic cell plasma membrane sinusoids]. 1979 Biochimie pmid:534664
Gershbein LL and Singh EJ Hydrocarbons of dogfish and cod livers and herring oil. 1969 J Am Oil Chem Soc pmid:5345048
Akhtar M et al. The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. 1969 Biochem. J. pmid:5343788
Werthemann L and Johnson WS Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:5275377
Werthemann L and Johnson WS Application of the chloro ketal Claisen reaction to the total synthesis of squalene. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:5274470
Habczyńska D et al. [The effect of squalene and cholesterol on the histological picture of the periodontium in white rats]. 1970 Oct-Nov Czas Stomatol pmid:5274119
Yamamoto S et al. Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. 1969 Proc. Natl. Acad. Sci. U.S.A. pmid:5257956
Johnson WS Nonenzymic biogenetic-like olefinic cyclizations. 1967 Trans N Y Acad Sci pmid:5237390
Garbuzov AG et al. Presence of squalene in human aorta. 1966 May-Jun Fed Proc Transl Suppl pmid:5222095
Shamberger RJ Inhibitory effect of vitamin A on carcinogenesis. 1971 J. Natl. Cancer Inst. pmid:5157584
Adrangui M et al. [Water-surfactant-oil diagrams based on perhydrosqualene and triglycerides (Miglyol 812). Study of emulsion phases and stability]. 1979 Pharm Acta Helv pmid:515109
Chida N and Okamura T Increased cholesterol-biosynthesis in familial hypercholesterolemia. 1971 Tohoku J. Exp. Med. pmid:5140375
van Tamelen EE et al. Formation of A-B cis- and trans-19-norlanosterols by enzymic cyclization of 6'-norsqualene 2,3-oxide. 1971 J. Am. Chem. Soc. pmid:5135874
Wells JW Steroids in the pineal gland of the domestic fowl (Gallus domesticus): cholesterol and its biosynthesis. 1971 Comp. Biochem. Physiol., B pmid:5133342
Boguslawski W and Zelewski L Inhibition of cholesterol biosynthesis by the respiratory chain inhibitors in human placenta and in rat liver. 1971 Biochem. Pharmacol. pmid:5132889
Taylor RF and Ikawa M Gas chromatography of carotenoids. 1971 Anal. Biochem. pmid:5130948
Ramsey RB et al. Squalene-like isoprenoid hydrocarbons in bovine brain. 1971 J. Neurochem. pmid:5129357
Smith AG and Goad LJ Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. 1971 Biochem. J. pmid:5126917
Popják G Specificity of enzymes of sterol biosynthesis. 1971 Harvey Lect. pmid:5123650
Woods RA Nystatin-resistant mutants of yeast: alterations in sterol content. 1971 J. Bacteriol. pmid:5122815
Frier BM and Saudek CD Cholesterol metabolism in diabetes: the effect of insulin on the kinetics of plasma squalene. 1979 J. Clin. Endocrinol. Metab. pmid:511973
Oesch F et al. Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. 1971 Arch. Biochem. Biophys. pmid:5117530
van Leusden HA et al. Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. 1971 Acta Endocrinol. pmid:5108099
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Wysocki SJ et al. Amniotic fluid squalene and fetal maturity. 1979 Br J Obstet Gynaecol pmid:508672
Slakey LL et al. The effect of starvation and re-feeding on the rates of synthesis and degradation of enzyms effecting intermediate reactions in the synthesis of cholesterol and fatty acids in rat liver. 1972 Biochem. J. pmid:5085557
Cotterill JA et al. Age and sex variation in skin surface lipid composition and sebum excretion rate. 1972 Br. J. Dermatol. pmid:5077864
Edkins E and Hansen IA Wax esters secreted by the uropygial glands of some Australian waterfowl, including the magpie goose. 1972 Comp. Biochem. Physiol., B pmid:5075378
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
Cunliffe WJ et al. An explanation fro chloracne -- an industrial hazard. 1975 Acta Derm. Venereol. pmid:50695
Ainsworth L and Nitchuk WM Cholesterol biosynthesis by sheep foetal liver and placenta in vitro. 1972 J. Endocrinol. pmid:5062219
Coates RM and Robinson WH Solvolysis of trans-2,2-dimethyl-3-(2'-methylpropenyl)cyclobutyl tosylate. Model reactions relevant to squalene biosynthesis. 1972 J. Am. Chem. Soc. pmid:5053868
Ramsey RB et al. Distribution of alkanes in normal and atherosclerotic rabbit aortas. 1972 May-Jun Atherosclerosis pmid:5051654
Mullakhanbhai MF and Francis GW Bacterial lipids. 1. Lipid constituents of a moderately halophilic bacterium. 1972 Acta Chem Scand pmid:5049648
Nicolosi RJ et al. Lipid accumulation in muscular foci in White Carneau and Show Racer pigeon aortas. 1972 Exp. Mol. Pathol. pmid:5043333
Avigan J et al. In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. 1972 Biochim. Biophys. Acta pmid:5041430
Kushwaha SC et al. Isolation and identification of dehydrosqualene and C 40 -carotenoid pigments in Halobacterium cutirubrum. 1972 Biochim. Biophys. Acta pmid:5038263
Kramer JK et al. Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. 1972 Biochim. Biophys. Acta pmid:5037322
Tai HH and Bloch K Squalene epoxidase of rat liver. 1972 J. Biol. Chem. pmid:5033388
Bazzano G and Bazzano GS Hypocholesterolemic effect of -ketoglutarate in the Mongolian gerbil. 1972 Proc. Soc. Exp. Biol. Med. pmid:5033114
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Nitchuk WM and Ainsworth L The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. 1972 Steroids pmid:5028884
Kligman LH and Kligman AM The effect on rhino mouse skin of agents which influence keratinization and exfoliation. 1979 J. Invest. Dermatol. pmid:501133
Downing DT et al. Changes in skin surface lipid composition induced by severe caloric restriction in man. 1972 Am. J. Clin. Nutr. pmid:5010536
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Goodfellow RD and Liu GC Squalene metabolism in the larva of the fly, Sarcophaga bullata. 1972 J. Insect Physiol. pmid:5009197
Caras IW and Bloch K Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase. 1979 J. Biol. Chem. pmid:500676
Chang TY et al. Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. 1979 J. Biol. Chem. pmid:500643
Dean PD The cyclases of triterpene and sterol biosynthesis. 1971 Steroidologia pmid:5004310
Anding C et al. Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. 1971 Eur. J. Biochem. pmid:5003307
Nes WR Regulation of the sequencing in sterol biosynthesis. 1971 Lipids pmid:4997338
Ferne M et al. [Isolation and characterization of various membrane fractions type active in the synthesis in vitro of squalene and obtained from anergic tissue cultures of tobacco]. 1971 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4997022
St Clair RW et al. Influence of atherosclerosis on the composition, synthesis, and esterification of lipids in aortas of squirrel monkeys (Saimiri sciureus). 1969 Sep-Oct J Atheroscler Res pmid:4986077
Fabre-Joneau M et al. [The nature and distribution of hydrocarbons in the yeast Candida utilis]. 1969 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4980247
Cornforth JW Olefin alkylation in biosynthesis. 1968 Angew. Chem. Int. Ed. Engl. pmid:4976264
Short RV The synthesis and secretion of steroids by the corpus luteum. 1967 Arch Anat Microsc Morphol Exp pmid:4973334
Lofland HB et al. Atherosclerosis in Cebus monkeys. II. Arterial metabolism. 1968 Exp. Mol. Pathol. pmid:4969998
Benveniste P et al. [Biosynthesis of squalene with the help of microsomes originating from the tissue of tobacco cultivated in vitro]. 1967 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4967365
Morton RA Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. 1970 Biochem. Soc. Symp. pmid:4944436
Bird CW et al. Steroids and squalene in Methylococcus capsulatus grown on methane. 1971 Nature pmid:4929985
Yamamoto S [Oxidative cyclization of squalene. Biosynthesis of sterols]. 1970 Tanpakushitsu Kakusan Koso pmid:4912088