| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronavirus Infections | D018352 | 4 associated lipids |
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Viremia | D014766 | 4 associated lipids |
| Lipodystrophy | D008060 | 4 associated lipids |
| Tinea Versicolor | D014010 | 5 associated lipids |
| Keratitis, Herpetic | D016849 | 5 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Parasitemia | D018512 | 5 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Chronic Disease | D002908 | 7 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qureshi AA et al. | Squalene synthetase. II. Purification and properties of bakers' yeast enzyme. | 1973 | J. Biol. Chem. | pmid:4348552 |
| Green TR and Baisted DJ | Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. | 1972 | Biochem. J. | pmid:4348263 |
| Heintz R et al. | Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. | 1972 | Biochem. Biophys. Res. Commun. | pmid:4344813 |
| Qureshi AA et al. | Squalene synthetase. I. Dissociation and reassociation of enzyme complex. | 1972 | Biochem. Biophys. Res. Commun. | pmid:4341049 |
| Stone KJ and Strominger JL | Inhibition of sterol biosynthesis by bacitracin. | 1972 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4338587 |
| Polito A et al. | Artificial substrates in squalene and sterol biosynthesis. | 1972 | J. Biol. Chem. | pmid:4337856 |
| Slakey LL et al. | The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene. | 1972 | J. Biol. Chem. | pmid:4337504 |
| Green TR and Baisted DJ | Development of the squalene-synthesizing system during early stages of pea seed germination. | 1971 | Biochem. J. | pmid:4335540 |
| Popják G | Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4332649 |
| Ogura K et al. | Enzymic formation of squalene homologs from farnesyl Pyrophosphate homologs. | 1972 | J. Am. Chem. Soc. | pmid:4332125 |
| Bloxham DP and Akhtar M | Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. | 1971 | Biochem. J. | pmid:4331371 |
| Goodwin TW | Biosynthesis of carotenoids and plant triterpenes. | 1971 | Biochem. J. | pmid:4331177 |
| Rilling HC et al. | Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. | 1971 | J. Am. Chem. Soc. | pmid:4323746 |
| Tamelen EE and Schwartz MA | Mechanism of presqualene pyrophosphate-squalene biosynthesis. | 1971 | J. Am. Chem. Soc. | pmid:4323745 |
| Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
| Epstein WW and Rilling HC | Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. | 1970 | J. Biol. Chem. | pmid:4318477 |
| Suzue G and Porter JW | Enzymatic synthesis of lycopene from [4-14C]isopentenyl pyrophosphate. | 1969 | Biochim. Biophys. Acta | pmid:4308120 |
| Frayha GJ and Fairbairn D | Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda). | 1969 | Comp. Biochem. Physiol. | pmid:4306773 |
| Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
| Kelley MT et al. | Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. | 1969 | J. Lipid Res. | pmid:4305711 |
| Hayaishi O and Nozaki M | Nature and mechanisms of oxygenases. | 1969 | Science | pmid:4304952 |
| Shafai T and Lewin LM | Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. | 1968 | Biochim. Biophys. Acta | pmid:4298231 |
| Jollow D et al. | The biogenesis of mitochondria. 3. The lipid composition of aerobically and anaerobically grown Saccharomyces cerevisiae as related to the membrane systems of the cells. | 1968 | J. Cell Biol. | pmid:4297785 |
| Rees HH et al. | Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. | 1968 | Biochem. J. | pmid:4297048 |
| Lynen F | [The biochemical basis of the biosynthesis of cholesterol and fatty acids]. | 1966 | Wien. Klin. Wochenschr. | pmid:4296920 |
| Stone KJ and Hemming FW | The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. | 1967 | Biochem. J. | pmid:4292001 |
| Gaylor JL et al. | Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. | 1966 | J. Lipid Res. | pmid:4290536 |
| Nightingale MS et al. | Testicular sterols. VI. Incorporation of mevalonate into squalene and sterols by cell-free preparations of testicular tissue. | 1967 | J. Biol. Chem. | pmid:4290213 |
| Rilling HC | A new intermediate in the biosynthesis of squalene. | 1966 | J. Biol. Chem. | pmid:4287912 |
| Dalidowicz JE and McDonald HJ | Site of the in vitro inhibition of cholesterol biosynthesis by tolbutamide and phenethylbiguanide. | 1965 | Biochemistry | pmid:4284598 |
| Stone KJ and Hemming FW | The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. | 1965 | Biochem. J. | pmid:4284430 |
| Krishna G et al. | An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene. | 1964 | Biochem. Biophys. Res. Commun. | pmid:4284347 |
| Yarkoni E and Rapp HJ | Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil. | 1979 | Cancer Res. | pmid:427795 |
| Dennick RG and Dean PD | Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. | 1974 | J. Neurochem. | pmid:4277662 |
| Cunliffe WJ et al. | Tetracycline and acne vulgaris: a clinical and laboratory investigation. | 1973 | Br Med J | pmid:4271323 |
| Gloor M et al. | [Composition of skin surface lipids in persons with seborrhoea sicca and seborrhoea oleosa (author's transl)]. | 1973 | Arch Dermatol Forsch | pmid:4270568 |
| Williams M et al. | The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. | 1973 | Br. J. Dermatol. | pmid:4270005 |
| Asakawa A et al. | The effect of nicotinamide on the cholesterol biosynthesis by cell-free rat brain extract. | 1972 | J Nihon Univ Sch Dent | pmid:4269195 |
| Bhavani BR and Short RV | Formation of steroids by the pregnant mare. 3. Metabolism of 14C-squalene and 3H-dehydroisoandrosterone injected into the fetal circulation. | 1973 | Endocrinology | pmid:4267110 |
| Tronnier H | [Methodological problems in exogenous and endogenous influencing on the skin surface]. | 1972 | Arch Dermatol Forsch | pmid:4265238 |
| Gloor M et al. | Quantity and composition of skin surface lipids and alkaline-resistance in subjects with contact allergy and in healthy controls. | 1972 | Arch Dermatol Forsch | pmid:4264242 |
| Cotterill JA et al. | Further observations on the pathogenesis of acne. | 1972 | Br Med J | pmid:4262616 |
| Gloor M et al. | [Influence of skin surface lipids on the result of Burckhardt's alkali resistance determination]. | 1972 | Berufsdermatosen | pmid:4262349 |
| Gloor M et al. | [Skin surface lipids: qualitative and quantitative determination in patients with acne vulgaris and controls. I]. | 1972 | Arch Dermatol Forsch | pmid:4260600 |
| Cotterill JA et al. | Variations in skin surface lipid composition and sebum excretion rate with different sampling techniques. II. | 1972 | Br. J. Dermatol. | pmid:4260102 |
| Cuncliffe WJ et al. | Skin surface lipids in acne. | 1971 | Br. J. Dermatol. | pmid:4257142 |
| Summerly R and Woodbury S | The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland. | 1971 | Br. J. Dermatol. | pmid:4257140 |
| Cotterill JA et al. | The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris. | 1971 | Br. J. Dermatol. | pmid:4255131 |
| Cotterill JA et al. | Sebum excretion rate and biochemistry in patients with acne vulgaris treated by oral fenfluramine. | 1971 | Br. J. Dermatol. | pmid:4255130 |
| Kligman AM et al. | Comedogenicity of human sebum. | 1970 | Arch Dermatol | pmid:4247928 |
| Whitehouse MW et al. | Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. | 1974 | Immunology | pmid:4214125 |
| Saxena SC and Zandee DI | Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. | 1969 | Arch. Int. Physiol. Biochim. | pmid:4188405 |
| Theiner M and Friedman L | Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. | 1969 | Proc. Soc. Exp. Biol. Med. | pmid:4183040 |
| Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. | 1968 | Arch. Int. Physiol. Biochim. | pmid:4178041 |
| Gianelly AA and Terner C | Inhibition of cholesterol biosynthesis by dehydroepiandrosterone in lactating mammary gland. | 1968 | Endocrinology | pmid:4177463 |
| Voogt PA | Biosynthesis of 3-beta-sterols in a snail, Arion rufus L., from 1-14C-acetate. | 1967 | Arch. Int. Physiol. Biochim. | pmid:4167714 |
| Gosselin L and Duvivier J | [On the utilization of C14-2-mevalonic acid by cell fractions of bovine adrenal gland homogenates]. | 1965 | Arch. Int. Physiol. Biochim. | pmid:4158100 |
| Gosselin L | [Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides]. | 1964 | Arch. Int. Physiol. Biochim. | pmid:4157959 |
| Muscio F et al. | Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis. | 1974 | J. Biol. Chem. | pmid:4152099 |
| Strauss JS et al. | Surface lipid composition in children with protein-calorie malnutrition. | 1978 | Am. J. Clin. Nutr. | pmid:414616 |
| Qureshi AA et al. | Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase. | 1973 | J. Biol. Chem. | pmid:4144543 |
| Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in mollusca. X. Biosynthesis and composition of 3 beta-sterols in Cephalopoda. | 1973 | Arch. Int. Physiol. Biochim. | pmid:4127479 |
| Cotterill JA et al. | Variation in skin surface lipid composition and sebum excretion rate with time. | 1973 | Acta Derm. Venereol. | pmid:4127454 |
| Kawaguchi A et al. | Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. | 1973 | Biochim. Biophys. Acta | pmid:4120185 |
| Popják G and Agnew WS | Squalene synthetase. | 1979 | Mol. Cell. Biochem. | pmid:41173 |
| Sipe JD and Holmlund CE | A comparison of the effects of some hypocholesteremic compounds on squalene metabolism in Tetrahymena pyriformis and rat liver. | 1972 | Biochim. Biophys. Acta | pmid:4116026 |
| Voogt PA and Van der Horst DJ | Investigations of the capacity of synthesizing 3 -sterols in mollusca. 8. The biosynthesis of 3 -sterols in the pulmonates "Succinea putris" and "Arianta arbustorum". | 1972 | Arch. Int. Physiol. Biochim. | pmid:4114875 |
| Singh EJ et al. | Hydrocarbons in human cervical mucus and the effect of oral contraception. | 1972 | J Reprod Med | pmid:4113025 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Van TAMELEN EE and Freed JH | Biochemical conversion of partially cyclized squalene 2,3-oxide types to the lanosterol system. Views on the normal enzymic cyclization process. | 1970 | J. Am. Chem. Soc. | pmid:4098774 |
| Rilling HC | The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture. | 1985 | Biochem. Soc. Trans. | pmid:4092833 |
| Nosaka Y et al. | Biliary squalene levels in hepatobiliary disease. | 1985 | Gastroenterol. Jpn. | pmid:4054510 |
| Goad LJ et al. | Effect of the allylamine antifungal drug SF 86-327 on the growth and sterol synthesis of Leishmania mexicana mexicana promastigotes. | 1985 | Biochem. Pharmacol. | pmid:4052119 |
| Yoshimura H et al. | [Stimulating effect of squalene on fecal excretion of a high toxic 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) in rats]. | 1985 | Fukuoka Igaku Zasshi | pmid:4043918 |
| Yamanishi Y et al. | Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis. | 1985 | Gastroenterol. Jpn. | pmid:4043657 |
| Gower DB et al. | Axillary 5 alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. | 1985 | Experientia | pmid:4043321 |
| Ono T et al. | Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system. | 1977 | Biochim. Biophys. Acta | pmid:403952 |
| Ryder NS | Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. | 1985 | Antimicrob. Agents Chemother. | pmid:4039119 |
| Chin J and Bloch K | Stimulation by unsaturated fatty acid of squalene uptake in rat liver microsomes. | 1985 | J. Lipid Res. | pmid:4031660 |
| Khullar N et al. | Immunomodulation of experimental malaria by MDP. | 1985 | Indian J Malariol | pmid:4029457 |
| McNamara DJ et al. | Role of the kidneys in the metabolism of plasma mevalonate. Studies in humans and in rhesus monkeys. | 1985 | J. Clin. Invest. | pmid:4019781 |
| Duriatti A et al. | In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules. | 1985 | Biochem. Pharmacol. | pmid:4015713 |
| Yamada Y et al. | Oxidation of acyclic terpenoids by Corynebacterium sp. | 1985 | Appl. Environ. Microbiol. | pmid:4004225 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Williams ML and Elias PM | Heterogeneity in autosomal recessive ichthyosis. Clinical and biochemical differentiation of lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma. | 1985 | Arch Dermatol | pmid:3977371 |
| Vuoristo M and Miettinen TA | Enhanced synthesis of cholesterol and its precursors in jejunal mucosa in coeliac disease. | 1986 | Gut | pmid:3957109 |
| Pentchev PG et al. | The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. | 1986 | J. Biol. Chem. | pmid:3949747 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Garrett IR et al. | Ambivalent properties of gold drugs in adjuvant induced polyarthritis in rats. | 1985 | J. Rheumatol. | pmid:3937896 |
| Yamaguchi T et al. | Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system. | 1985 | Jpn. J. Cancer Res. | pmid:3935620 |
| Johnson RC and Shah SN | Metabolism of intracerebrally injected mevalonate in brain of suckling and young adult rats. | 1985 | Neurochem. Res. | pmid:3925358 |
| Harrison DM | The biosynthesis of triterpenoids and steroids. | 1985 | Nat Prod Rep | pmid:3913885 |
| Morita T and Nozawa Y | Effects of antifungal agents on ergosterol biosynthesis in Candida albicans and Trichophyton mentagrophytes: differential inhibitory sites of naphthiomate and miconazole. | 1985 | J. Invest. Dermatol. | pmid:3902987 |
| Pinto WJ et al. | Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3896318 |
| Nishino T and Katsuki H | Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase. | 1985 | Meth. Enzymol. | pmid:3894880 |
| Kashimoto T et al. | [Studies on therapeutic effect of 13-cis retinoic acid and squalene on symptoms of PCDFs poisoning in monkeys]. | 1985 | Fukuoka Igaku Zasshi | pmid:3862639 |
| Masihi KN et al. | Modulation of natural killer cytotoxicity by muramyl dipeptide and trehalose dimycolate incorporated in squalane droplets. | 1987 | Cancer Immunol. Immunother. | pmid:3815418 |
| Miettinen TA et al. | Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism. | 1987 | Am. Heart J. | pmid:3812207 |
| Kuswik-Rabiega G and Rilling HC | Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. | 1987 | J. Biol. Chem. | pmid:3805037 |
| Gerst N et al. | Inhibition of cholesterol biosynthesis in 3T3 fibroblasts by 2-aza-2,3-dihydrosqualene, a rationally designed 2,3-oxidosqualene cyclase inhibitor. | 1986 | Biochem. Pharmacol. | pmid:3790151 |